Navigation Links
Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
Date:3/21/2010

ation needed to make a protein in the first place.

"In principle," says Davis, "that means every protein now is druggable because its inhibition is accomplished by destroying the mRNA. And we can go after mRNAs in a very designed way given all the genomic data that are and will become available."

Still, there have been numerous potential roadblocks to the application of RNAi technology as therapy in humans. One of the most problematic has been finding a way to ferry the therapeutics, which are made up of fragile siRNAs, into tumor cells after direct injection into the bloodstream. Davis, however, had a solution. Even before the discovery of RNAi, he and his team had begun working on ways to deliver nucleic acids into cells via systemic administration. They eventually created a four-component systemfeaturing a unique polymerthat can self-assemble into a targeted, siRNA-containing nanoparticle. The siRNA delivery system is under clinical development by Calando Pharmaceuticals, Inc., a Pasadena-based nanobiotech company.

"These nanoparticles are able to take the siRNAs to the targeted site within the body," says Davis. Once they reach their targetin this case, the cancer cells within tumorsthe nanoparticles enter the cells and release the siRNAs.

The scientific results described in the Nature paper are from a Phase I clinical trial of these nanoparticles that began treating patients in May 2008. Phase I trials are, by definition, safety trials; the idea is to see if and at what level the drug or other therapy turns harmful or toxic. These trials can also provide an in-human scientific proof of conceptwhich is exactly what is being reported in the Nature paper.

Using a new technique developed at Caltech, the team was able to detect and image nanoparticles inside cells biopsied from the tumors of several of the trial's participants. In addition, Davis and his colleagues were able to show that the higher the nanopart
'/>"/>

Contact: Jon Weiner
jrweiner@caltech.edu
626-395-3226
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Caltech-led researchers find negative cues from appearance alone matter for real elections
2. ARS study provides a better understanding of how mosquitoes find a host
3. Seafarers scourge provides hope for biofuel future
4. March of Dimes provides $2.6 million in new funding for preterm birth research
5. A deadly scorpion provides a safe pesticide
6. Study provides insight into pathway linked to obesity
7. Sweet corn study provides large-scale picture of better fields
8. BIO-key(R) Provides Update to Special Shareholder Meeting
9. New research provides insights into potential ecological costs and cobenefits of REDD
10. ERC provides millions for biodiversity research
11. Joint US-Norwegian study provides new insights into marine ecosystems and fisheries production
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
(Date:9/21/2014)... (black-eyed peas) is a fascinating example of how science ... the story of the scientist behind the research. ... the 21st Century to serve as an accessible summary ... recently published by the Crop Science Society of America, ... , Singh has devoted his life,s work to solving ...
(Date:9/21/2014)... MA -- In recent years, new strains of bacteria ... Each year, these superbugs, including drug-resistant forms of tuberculosis ... and kill at least 23,000. Despite the urgent need ... classes of antibiotics in the past decade. , MIT ... these superbugs. Using a gene-editing system that can disable ...
(Date:9/21/2014)... a protein therapy that disrupts the process that causes ... travel through the blood stream and start aggressive new ... as metastasis, can cause cancer to spread with deadly ... to cancer fall prey to metastatic forms of the ... who describes a new therapeutic approach in Nature ...
Breaking Biology News(10 mins):Battling superbugs 2Battling superbugs 3Battling superbugs 4Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4
... long puzzled scientists, and several scenarios have been proposed ... group appeared virtually simultaneously on Asia, Europe and North ... new research using the latest evidence suggests a completely ... that sudden, rapid global warming drove the dispersal. ...
... Researchers at the Burnham Institute for Medical Research have ... free radicals and accumulation of misfolded proteins that lead ... such as Alzheimer's and Parkinson's Disease. , ... protein that is necessary for proper protein folding in ...
... The study of 18 HIV-positive subjects shows that HIV in ... HIV that lives in the blood and peripheral tissues. , ... with the presence of a particular mutation in the HIV ... 2006 issue of Brain. It was led by Satish K. ...
Cached Biology News:Ancient global warming drove early primates' dispersal 2Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's 2Viral genetic differences are possible key to HIV dementia 2Viral genetic differences are possible key to HIV dementia 3
(Date:9/23/2014)... The Minnesota High Tech Association ... cellular modems , platforms and application-specific remote monitoring ... for the 2014 Tekne Awards. The awards ... Convention Center on Thursday, November 13th. The Tekne ... shown superior technology innovation and leadership. , ...
(Date:9/22/2014)... Pearl's Premium Ultra Low Maintenance Lawn Seed ... seed this week with the release of their Pearl's ... the fact that it is time to plant now ... , As of the date 6/4/13, Pearl's Premium had ... experts and the media including: The National Gardeners ...
(Date:9/22/2014)... Thanks to new LEGO-like components developed by researchers ... is now possible to build a 3-D microfluidic ... small modules by hand. , Microfluidic systems ... and biotechnology to precisely manipulate small volumes of ... or DNA analysis, pathogen detection, clinical diagnostic testing, ...
(Date:9/22/2014)... a new star-shaped molecule made up of interlocking rings, which ... , Known as a ,Star of David, molecule, scientists ... of a century and the team,s findings are published in ... two molecular triangles, entwined about each other three times into ... triangle is 114 atoms in length around the perimeter. The ...
Breaking Biology Technology:NimbeLink Named Finalist for 15th Annual Tekne Awards 2NimbeLink Named Finalist for 15th Annual Tekne Awards 3Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 3Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 4Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 5
... Finger Nuclease Platform enables Precise, Permanent, and ... Heritable Modification of the Genome, ... CompoZr(TM) platform of zinc finger nuclease (ZFN),reagents. The CompoZr ZFN ... to target and precisely manipulate the genome,of living cells, resulting ...
... plant-based extract, is better than metformin, the leading Type 2 diabetes ... ... Winter Haven, FL (PRWEB) September 16, 2008 -- A ... 2 diabetics better than a leading prescription drug, according to the ...
... Development of Gene Expression Signatures Derived by COXEN ... Molecular Test of Responsiveness to Current Treatments, ... Transgenomic (OTC Bulletin Board: TBIO) today announced a ... test which will guide,clinicians in their choice of ...
Cached Biology Technology:Sigma-Aldrich Launches Breakthrough Genome-Editing Tools 2Sigma-Aldrich Launches Breakthrough Genome-Editing Tools 3Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin™ 2Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 2Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 3Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 4
... is proud to work in collaboration with ... 25mm syringe filters in a variety of ... licensed for use on the Caliper TPWII, ... and Pricing for our Automation Certified Syringe ...
... 3 Dodeca cell with multi-casting chamber is used ... 12 mini format handcast (8.3 x 7.3 cm) ... cell requires 3.4-4.4 L of buffer and includes ... attaches to an external refrigerated circulator (not included), ...
...
... This product has been developed to ... peroxidase labeled proteins. Stability is increased ... to 2-8 centigrade. This product is ... no mercury or azide. This formulation ...
Biology Products: