Navigation Links
Caltech engineers build smart petri dish
Date:10/3/2011

s a scanning light source. The device is placed in an incubator with a wire running from the chip to a laptop outside the incubator. As the image sensor takes pictures of the culture, that information is sent out to the laptop, enabling the researchers to acquire and save images of the cells as they are growing in real time. The technology is particularly adept at imaging confluent cells -- those that grow very close to one another and typically cover the entire petri dish.

"Until now, imaging of confluent cell cultures has been a highly labor-intensive process in which the traditional microscope has to serve as an expensive and suboptimal workhorse," says Changhuei Yang, senior author of the study and professor of electrical engineering and bioengineering at Caltech. "What this technology allows us to do is create a system in which you can do wide field-of-view microscopy imaging of confluent cell samples. It capitalizes on the use of readily available image-sensor technology, which is found in all cell-phone cameras."

In addition to simplifying medical diagnostic tests, the ePetri platform may be useful in various other areas, such as drug screening and the detection of toxic compounds. It has also proved to be practical for use in basic research.

Caltech biologist Michael Elowitz, a coauthor on the study, has put the ePetri system to the test, using it to observe embryonic stem cells. Stem cells in different parts of a petri dish often behave differently, changing into various types of other, more specialized cells. Using a conventional microscope with its lens's limitations, a researcher effectively wears blinders and is only able to focus on one region of the petri dish at a time, says Elowitz. But by using the ePetri platform, Elowitz was able to follow the stem-cell changes over the entire surface of the device.

"It radically reconceives the whole idea of what a light microscope is," says Elowitz, a professor of biology a
'/>"/>

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Caltech researchers increase the potency of HIV-battling proteins
2. Think healthy, eat healthy: Caltech scientists show link between attention and self-control
3. Caltech researchers create the first artificial neural network out of DNA
4. Caltech scientist awarded $5 million grant for plant research
5. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
6. 2011 HFSP Nakasone Award for Michael Elowitz of Caltech
7. Young Caltech engineers recognized for innovative work in disease diagnostic technologies
8. Tip sheet: Caltech researchers presenting at AAAS
9. Caltech-led team creates damage-tolerant metallic glass
10. Caltech scientists describe the delicate balance in the brain that controls fear
11. NIH awards $11.5 million for new Caltech-led membrane-protein center
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech engineers build smart petri dish
(Date:8/1/2014)... -- Modern humans appear in the fossil record about ... years ago that making art and advanced tools became ... in the journal Current Anthropology finds that ... of testosterone levels at around the same time that ... technological innovation, making art and rapid cultural exchange probably ...
(Date:8/1/2014)... what causes them at the molecular level is even ... created the most detailed map to date of a ... diseases, such as age-related macular degeneration. The high-resolution molecular ... supplies blood and oxygen to the outer retina, itself ... of proteins in different areas of the choroid, the ...
(Date:8/1/2014)... the most diverse families in the ocean today -- ... originated more than 400 million years ago in the ... of its modern members. This Geology study ... online on 25 July 2014, tracks the remarkable evolutionary ... At is origin, the Lucinidae family remained at very ...
Breaking Biology News(10 mins):Society bloomed with gentler personalities and more feminine faces 2A map for eye disease 2Symbiotic survival 2Symbiotic survival 3Symbiotic survival 4Symbiotic survival 5Symbiotic survival 6Symbiotic survival 7Symbiotic survival 8Symbiotic survival 9Symbiotic survival 10Symbiotic survival 11Symbiotic survival 12Symbiotic survival 13Symbiotic survival 14
... which cancer cells travel from a tumor site and proliferate ... to cancer patients. According to the National Cancer Institute, most ... Virtually all types of cancer can spread to other parts ... are entrenched in the brain, patients typically have only a ...
... the sensitivity of Australia,s species and ecosystems to climate ... about biodiversity conservation. ,Climate change is likely to ... 2030, lead researcher, CSIRO,s Dr Michael Dunlop said.,By 2070, ... and widespread. Many of the environments our plants and ...
... Researchers at the National Institute of Standards and Technology ... candidate refrigerant fluids with low "global warming potential" (GWP) ... for many decades as well as other desirable ... the most extensive systematic search for a new class ...
Cached Biology News:Fighting melanoma's attraction to the brain 2Major changes needed to protect Australia's species and ecosystems 2New NIST screening method identifies 1,200 candidate refrigerants to combat global warming 2
(Date:8/1/2014)... Brook, NY (PRWEB) August 01, 2014 ... @APDN), a provider of DNA-based anti-counterfeiting technology and product ... August 12, 2014 to discuss its fiscal third quarter ... filed with the SEC by the end of the ... DNA Sciences, Inc. management will host a conference call ...
(Date:8/1/2014)... DUBLIN , Aug. 1, 2014 ... of the "The World Market for Flow ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... instruments that are now an important component of ... advanced diagnostic instruments for cancer diagnostics, but their ...
(Date:8/1/2014)... 1. 2014 As one of the 10 ... Annual Meeting & Clinical Lab Expo is the place ... are introduced to the healthcare world. This year, many ... exhibitors will include the latest diagnostic technology in the ... smartphones and biosensors have enabled the development of "labs-on-a-chip" ...
(Date:8/1/2014)... CHICAGO , Aug. 1, 2014 One ... the rise of personalized medicine, which is the practice ... medical treatments to a patient,s individual biology. Personalized diagnostics—laboratory ... a major role in the lab,s future. This fall, ... will feature the latest science in this exciting field ...
Breaking Biology Technology:Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 2Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 3The World Market for Flow Cytometry in IVD Applications 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3First-Ever AACC Virtual Conference to Focus on Personalized Diagnostics 2
... - Worldwide VELCADE(R) (bortezomib) for Injection sales surpassed $765 ... million in 2007 - ... myeloma, with launch on track for ... (Nasdaq: MLNM ) today reported 2007 non-GAAP net,income of $86.9 million and ...
... Feb. 7 ADVENTRX Pharmaceuticals,Inc. (Amex: ... data from,the Company,s marketing-enabling bioequivalence clinical study ... presentation at the 2008,American Association for Cancer ... 12 - 16, 2008 in San Diego, ...
... Ability to Prevent HIV from Replicating, GAITHERSBURG, ... company developing gene therapies for HIV and genetic,diseases, ... VRX496, a gene,therapy for the treatment of AIDS, ... Infections (CROI) in Boston, MA., "This appears ...
Cached Biology Technology:Millennium Over-Delivers on 2007 Goals and Financial Guidance 2Millennium Over-Delivers on 2007 Goals and Financial Guidance 3Millennium Over-Delivers on 2007 Goals and Financial Guidance 4Millennium Over-Delivers on 2007 Goals and Financial Guidance 5Millennium Over-Delivers on 2007 Goals and Financial Guidance 6Millennium Over-Delivers on 2007 Goals and Financial Guidance 7Millennium Over-Delivers on 2007 Goals and Financial Guidance 8Millennium Over-Delivers on 2007 Goals and Financial Guidance 9Millennium Over-Delivers on 2007 Goals and Financial Guidance 10Millennium Over-Delivers on 2007 Goals and Financial Guidance 11Millennium Over-Delivers on 2007 Goals and Financial Guidance 12Millennium Over-Delivers on 2007 Goals and Financial Guidance 13Millennium Over-Delivers on 2007 Goals and Financial Guidance 14Millennium Over-Delivers on 2007 Goals and Financial Guidance 15Millennium Over-Delivers on 2007 Goals and Financial Guidance 16Millennium Over-Delivers on 2007 Goals and Financial Guidance 17Millennium Over-Delivers on 2007 Goals and Financial Guidance 18ADVENTRX to Present Complete ANX-530 Pharmacokinetic Data at the 2008 American Association for Cancer Research Annual Meeting 2ADVENTRX to Present Complete ANX-530 Pharmacokinetic Data at the 2008 American Association for Cancer Research Annual Meeting 3VIRxSYS Announces Interim Results from VRX496 Gene Therapy Phase II Trial 2
... The S. pombe Whole Genome ... location analysis of yeast (S. pombe) ... immunoprecipitation (ChIP) with Agilent DNA microarrays. ... reliable binding data with greater true ...
... genomes has allowed the development of the ... The S. enterica Typhimurium (strain LT2) genome ... 4,440 ORFs) and a plasmid, pSLT (93,939 ... have been designed to amplify all putative ...
... own microplate stacker system, offers fast and ... host devices:, , Ultra Evolution , SAFIRE ... and SpectraFluor Plus , LS Series of ... supporting a wide range of detection and ...
... LabX light balance makes your life easier. It ... acquisition and management for one balance. *Instruments supported: ... TOLEDO AX, MX, UMX, AG, XS, XP, PR, SR, ... balances *Job management: ...
Biology Products: