PASADENA, Calif. -- The cameras in our cell phones have dramatically changed the way we share the special moments in our lives, making photographs instantly available to friends and family. Now, the imaging sensor chips that form the heart of these built-in cameras are helping engineers at the California Institute of Technology (Caltech) transform the way cell cultures are imaged by serving as the platform for a "smart" petri dish.
Dubbed ePetri, the device is described in a paper that appears online this week in the Proceedings of the National Academy of Sciences (PNAS).
Since the late 1800s, biologists have used petri dishes primarily to grow cells. In the medical field, they are used to identify bacterial infections, such as tuberculosis. Conventional use of a petri dish requires that the cells being cultured be placed in an incubator to grow. As the sample grows, it is removed -- often numerous times -- from the incubator to be studied under a microscope.
Not so with the ePetri, whose platform does away with the need for bulky microscopes and significantly reduces human labor time, while improving the way in which the culture growth can be recorded.
"Our ePetri dish is a compact, small, lens-free microscopy imaging platform. We can directly track the cell culture or bacteria culture within the incubator," explains Guoan Zheng, lead author of the study and a graduate student in electrical engineering at Caltech. "The data from the ePetri dish automatically transfers to a computer outside the incubator by a cable connection. Therefore, this technology can significantly streamline and improve cell culture experiments by cutting down on human labor and contamination risks."
The team built the platform prototype using a Google smart phone, a commercially available cell-phone image sensor, and Lego building blocks. The culture is placed on the image-sensor chip, while the phone's LED screen is used a
|Contact: Deborah Williams-Hedges|
California Institute of Technology