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Caltech biologists discover how T cells make a commitment
Date:7/2/2010

ther cells in completely different types of tissue, such as brain and skin and mammary tissue, but that's how the body works. There's no confusion, because something like brain tissue and mammary tissue will never be a T cell."

When Bcl11b is not presentas in mice genetically altered to lack the geneT cells "don't turn out right," Rothenberg says. Indeed, T cells in individuals with T-cell leukemia have been found to lack the gene. "It may make them more susceptible to the effects of radiation, because the cells don't know when to stop growing," she says. "We think that the loss of one of the two copies of the gene is enough to prevent cells from growing appropriately."


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Contact: Kathy Svitil
ksvitil@caltech.edu
626-395-8022
California Institute of Technology
Source:Eurekalert

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