LA JOLLA, Calif., September 12, 2012 The California Institute for Regenerative Medicine (CIRM) has awarded a $1.58 million grant to Huei-Sheng Vincent Chen, Ph.D., associate professor at Sanford-Burnham Medical Research Institute (Sanford-Burnham). Chen's proposal was one of 28 new projects funded as part of CIRM's Basic Biology IV awards program, which supports basic research aimed at increasing our understanding of stem cells and how to work with them. This new funding will allow Chen and his team to develop personalized models of inherited heart conditions using stem cells derived from patients' own skin cells. They will also use these models to develop new therapies.
"Most heart conditions that cause sudden death in young peoplethose under age 35are caused by inherited genetic mutations. But doctors have a hard time treating these types of heart conditions because not much is known about how genetic mutations cause them and because they're usually diagnosed late in the disease process," Chen said. "At the moment, the only way to treat these inherited heart diseases is to implant a heart-shocking device to prevent sudden death. More frequently, however, no therapy is available to slow the disease's progression."
To help overcome these problems, Chen's team is using a special type of stem cell (called induced pluripotent stem cells or iPSCs) that are made from human skin cellsin this case skin cells from patients with genetic mutations affecting their hearts. These stem cells can then be used to generate unlimited numbers of heart cells that carry the person's unique genetic mutations. Using these patient-specific heart cells, Chen and colleagues plan to look for the causes of abnormalities that lead to clinical heart disease symptoms, heart failure, and sudden death.
In this newly funded project, Chen's team will generate more patient-specific stem cells from skin cells of heart disease patients who have similar clinical prese
|Contact: Heather Buschman, Ph.D.|
Sanford-Burnham Medical Research Institute