Navigation Links
Calcium connections: Basic pathway for maintaining cell's fuel stores
Date:7/27/2010

PHILADELPHIA University of Pennsylvania School of Medicine researchers have described a previously unknown biological mechanism in cells that prevents them from cannibalizing themselves for fuel. The mechanism involves the fuel used by cells under normal conditions and relies on an ongoing transfer of calcium between two cell components via an ion channel. Without this transfer, cells start consuming themselves as a way of to get enough energy.

"Altered metabolism is a feature of many diseases, as well as aging," says senior author J. Kevin Foskett, PhD, professor of Physiology. "The definition of this essential mechanism for regulating cell energy will have implications for a wide variety of physiological processes and diseases." The investigators describe their findings in the cover article in the most recent issue of Cell.

Most healthy cells in the body rely on a complicated process called oxidative phosphorylation to produce the fuel ATP. Knowledge about how ATP is produced by the cell's mitochondria, the energy storehouse, is important for understanding normal cell metabolism, which will provide insights into abnormal cell metabolism, as in the case of cancer.

Foskett and colleagues discovered that a fundamental control system regulating ATP is an ongoing shuttling of calcium to the mitochondria from another cell component called the endoplasmic reticulum.

The endoplasmic reticulum is the major reservoir of calcium in cells. The stored calcium is released to adjacent mitochondria through a calcium ion channel called the IP3 receptor. The researchers found that this calcium release occurs at a low level all the time.

When the researchers interfered with the calcium release using genetic or pharmacological methods, the mitochondria were unable to produce enough ATP to meet the needs of the cell. This indicates that mitochondria rely on the ongoing calcium transfer to make enough ATP to support normal
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Vitamin and calcium supplements may reduce breast cancer risk
2. Understanding night blindness and calcium
3. Vitamin D and calcium interplay explored
4. Catching calcium waves could provide Alzheimers insights
5. UC Davis research confirms benefits of calcium and vitamin D in preventing fractures
6. Prolonged stress sparks ER to release calcium stores and induce cell death in aging-related diseases
7. Purdue study finds dairy better for bones than calcium carbonate
8. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
9. A diet rich in calcium aids weight loss
10. Calcium and vitamin D may not be the only protection against bone loss
11. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Calcium connections: Basic pathway for maintaining cell's fuel stores
(Date:8/12/2015)... NEW YORK , Aug. 12, 2015 /PRNewswire/ ... how hackers can attack Android phones to steal ... identifies the increasing availability of fingerprint scanners on ... of utmost concern. To secure biometrics on mobile ... platform to augment these convenient authentication systems with ...
(Date:8/11/2015)... Sweden , August 11, 2015 Today, ... FPC1155. Already received as well as expected revenues in 2015 that ... in FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a prominent smartphone manufacturer in ... ZUK selected FPC1 155 for ...
(Date:8/10/2015)... 2015 The latest 364 page report ... of the global border security market . Visiongain ... in 2015. Now: Border security is hard to ... the business critical issue you need to know about - ... objective analysis of how this will impact your company and ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9
... the University of Florida's McKnight Brain Institute have created ... time duplicates neurogenesis -- the process of generating new ... today's (June 13) Proceedings of the National Academy of ... the promise of producing a limitless supply of a ...
... Iron key to nitric oxide reductionResearchers at the Georgia ... the United Kingdom have uncovered a mechanism with which ... The findings, which could ultimately lead to the development ... 2005 issue of the journal Nature. , "Nitric oxide ...
... Infectious Diseases (NIAID), part of the National Institutes of ... cause such serious diseases as West Nile fever, yellow ... in different ways depending on whether they are transmitted ... new approaches to developing vaccines and treatments against these ...
Cached Biology News:For first time, brain cells generated in a dish 2For first time, brain cells generated in a dish 3Researchers uncover E. coli's defense mechanism 2Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses 2Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses 3
(Date:9/3/2015)... , Sept. 3, 2015 /PRNewswire/ - bioLytical Laboratories Inc., ... announce its study " Sensitivity of a rapid point ... enhanced by its affinity for HIV gp41 IgM antibodies ... Virology.  This study highlights INSTI,s ability to detect early ... findings at the 8 th annual International AIDS ...
(Date:9/3/2015)... ... September 03, 2015 , ... Park Systems announced that they ... 2015 at 9am PST. The webinar will focus on the methods and materials for ... printing, additive manufacturing is a broad term that encompasses “addition or fusion” of materials ...
(Date:9/2/2015)... Sept. 2, 2015 Axovant Sciences Ltd. (NYSE:  AXON), ... dementia, today announced upcoming presentations at three investor conferences: ... Baird 2015 Healthcare Conference in New York ... September 10 at 2:00 PM at the BioCentury NewsMakers Conference ... Broadway Hotel & Conference Center , Thursday, September 17 ...
(Date:9/2/2015)... , Sep. 02, 2015 ... has announced the addition of Jain PharmaBiotech,s new ... Companies" to their offering. This ... development of sequencing technologies, and their applications. Current ... as companies developing them. Various applications of sequencing ...
Breaking Biology Technology:bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 2bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 2Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 4Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2
... Debiopharm Group,(Debiopharm), a global independent biopharmaceutical development ... presented the ,Debiopharm,Life Sciences Award, to Hungarian ... in both fundamental and clinical neuroscience. Funded,by ... Federale de Lausanne,(EPFL), the ceremony took place ...
... BETHESDA, Md., Aug. 29 Sucampo,Pharmaceuticals, Inc. (Nasdaq: ... public offering have exercised in full their option to,purchase ... cover,over-allotments and that the closing of that purchase took ... at today,s closing were sold by a selling,stockholder and ...
... Webb Promoted to Newly Created Role of Senior Vice President of ... Regulatory, and Clinical Affairs, Philip R. Licari to Step Down as Chief ... ... Medical,Inc. (Nasdaq: NXTM ), the manufacturer of the NxStage System One (TM),portable ...
Cached Biology Technology:The Debiopharm Life Sciences Award Goes to Dr Nusser for his Outstanding Research in Neuroscience 2Sucampo Pharmaceuticals Announces Exercise and Closing of IPO Over-Allotment Option 2NxStage Medical Provides Update on Medisystems Acquisition 2NxStage Medical Provides Update on Medisystems Acquisition 3NxStage Medical Provides Update on Medisystems Acquisition 4NxStage Medical Provides Update on Medisystems Acquisition 5
... is the standard water based mounting medium ... the permanent preservation of peroxidase and alkaline ... to use and exhibits excellent optical characteristics. ... mounting medium that permits the long-term storage ...
... monoclonal antibody development to targets including proteins ... DNA, and cancer-specific surface antigens. A&Gs ... is completed in approximately 40 days (duration ... of antigens). Phase I: Immunization, test ...
PCR System for increased fidelity, yield and length of PCR products. Amplifies targets up to 10 kb from human genomic DNA....
...
Biology Products: