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Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
Date:11/7/2013

A recent prospective, randomized, placebo-controlled clinical trial reports that calcium and vitamin D supplementation improves bone density in a group of male veterans with epilepsy who were treated chronically with antiepileptic drugs (AEDs). The results published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), suggest that risedronate, a bisphosphonate, may help to prevent new vertebral fractures when taken with calcium and vitamin D supplementation.

Many patients with epilepsy are required to take chronically an AED such as phenytoin, phenobarbital, carbamazepine, primidone, and valproate alone or in combination to control seizures. There is much medical evidence reporting that these AEDs may accelerate bone loss, increasing the risk of osteoporotic fractures. In fact, previous studies found that more than 50% of adults with epilepsy who use AEDs showed decreased bone mass in their hips or spine and the overall fracture risk of patients with epilepsy is considered to be larger than the normal population.

"Long-term use of AEDs is associated with loss of bone mass and increased risk of osteoporosis," explains Dr. Antonio Lazzari with the VA Boston Healthcare System in Massachusetts and lead author of the present study. "Our study is the first longitudinal trial of a bisphosphonate (risedronate), along with calcium and vitamin D supplementation, in preventing and treating bone loss in male veterans with epilepsy receiving AED therapy."

The antiepileptic drug and osteoporosis prevention trial (ADOPT) was a prospective two-year randomized, double-blind, placebo-controlled phase IV clinical trial of 80 male veterans with epilepsy who were treated with an AED for a minimum of two years. All participants received calcium and vitamin D supplements, and were randomized to risedronate or placebo. Subjects received total body, hip, and spine bone density assessments at baseline, one year and two years f
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Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

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