Navigation Links
Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease
Date:4/16/2009

acity in the Brain of Female G93A Mice, An Animal Model of Amyotrophic Lateral Sclerosis (ALS) was conducted by Rajini Seevaratnam1 supervised by Mazen J. Hamadeh1,2 , and co-authored by Sandeep Raha2 and Mark A. Tarnopolsky2 (1School of Kinesiology and Health Science, York University, Toronto, ON, Canada; 2Department of Pediatrics and Medicine, McMaster University Hamilton, ON, Canada). The researchers will present their findings at the 122nd Annual Meeting of the American Physiological Society (APS; www.the-aps.org/press), which is part of the Experimental Biology 2009 scientific conference. The meeting will be held April 18-22, 2009 in New Orleans.

Study Design

Fifty-one G93A mice were randomly divided into eight groups: control (6 males, 8 females), coffee (5 males, 7 females), caffeine (5 males, 8 females), chlrogenic acid (5 males, 7 females). The control groups were fed a standard rodent diet and were not given any additional supplements. The intervention groups were provided with coffee, caffeine, and chlorogenic acid extracts, respectively, in amounts found in 5-10 cups of coffee per day, controlled for body weight.

Clinical measures: Food intake, body weight, body condition, ability to move, clinical score, and motor performance were all assessed for the effect of diet and time prior to animal sacrifice.

Molecular measures: Markers of oxidative stress (4-HNE; 3-NY), antioxidant enzyme protein content (MnSOD; CAT; GPx1; GR; GPx1 to GR ratio), and cell death (Bax; Bcl-2) were analyzed using the brains of these mice at age 108 days.

Statistical analysis was conducted for males and females separately.

At the end of the study, the researchers found that:

In males:

  • Coffee: increased food intake by 21%, decreased markers of oxidative stress by 39-65%, increased markers of antioxidant enzyme protein content by 46-139%, and decreased markers of cell death by 34-36%.
    '/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
703-967-2751
American Physiological Society
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A low dose of caffeine when pregnant may damage the heart of offspring for a lifetime
2. Post-exercise caffeine helps muscles refuel
3. Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
4. Gene therapy appears safe to regenerate gum tissue
5. Team approach appears to work best for insect colonies
6. Mars water appears to have been too salty to support life
7. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
8. Risk of common vaginal infection linked to preterm birth appears higher for blacks
9. Scripps research team solves structure of beneficial virus
10. Experts tackle shipment issues for beneficial radiation sources
11. Too much technology may be killing beneficial bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Portland Press Limited today announced an across-the-board increase ... , The 2013 InCites Journal Citation Reports (Thomson ... Biochemical Journal , Essays in Biochemistry ... Bioscience Reports all received increases in their ... Biochemical Society and published by Portland Press Limited. ...
(Date:7/30/2014)... decisions about what they eat, the Food and Drug ... the Nutrition Facts label found on nearly every food ... & Engineering News (C&EN), the weekly news magazine ... and the fight that has ensued. , Britt ... while the Nutrition Facts label has remained largely the ...
(Date:7/30/2014)... Brembs, professor of neurogenetics at the Institute of Zoology, ... readers and reviewers to run the underlying code within ... forward for scientific publishing, by demonstrating a completely novel ... , Figure 3 in fact doesn,t really exist. The ... F1000Research , and the figure is generated ,on the ...
Breaking Biology News(10 mins):Across-the-board Impact Factor increases for Portland Press Limited 2F1000Research brings static research figures to life 2
... coastal habitats may release as much as 1 billion tons ... higher than previously reported, according to a new Duke led ... , the analysis provides the most comprehensive estimate of global ... date: 0.15 to 1.2 billion tons. It suggests there is ...
... September 6, 2012The naturally occurring cytokine interleukin-18, or IL-18, ... implicated in serious inflammatory diseases for which the prognosis ... Therapies targeting IL-18 could prove effective against inflammatory diseases ... pulmonary disease (COPD), as described in a review article ...
... release is available in Spanish . ... (ICCAT) is to invest 1.5 million euros in two research ... 2012 by AZTI-Tecnalia, the technological centre specialised in marine and ... the first project, the consortium co-ordinated by AZTI-Tecnalia will capture, ...
Cached Biology News:Destroyed coastal habitats produce significant greenhouse gas 2Promising new drug target for inflammatory lung diseases 2AZTI-Tecnalia leads 2 research projects on bluefin tuna with 1.5 million euros investment 2
(Date:7/31/2014)... The global market for molecular diagnostics ... according to a new study by Grand View Research, ... the subsequent introduction of advanced cancer diagnostic technologies are ... the next six years. Moreover, the growing global base ... coupled with disease triggering lifestyle habits such as smoking ...
(Date:7/31/2014)... Miami, Fla. (PRWEB) July 31, 2014 The ... for distribution of its monthly news magazine, Kidney Cancer News. ... have a presence on a website maintained by an international ... noted an immediate increase in viewers.” , This month’s program ... of kidney tumors analyzed in a recent study. Kidney ...
(Date:7/30/2014)... 30, 2014 W. R. Grace ... of the REVELERIS® Prep purification system , ... chromatographers, and other researchers to perform both flash ... unit. , With the REVELERIS® Prep purification system, ... chromatography modes with a simple touch of the ...
(Date:7/30/2014)... 2014 While administrative claims and ... research for a relatively long period of time, ... the use of these ‘big data’ for comparisons ... combining today’s powerful computer technology with the plethora ... data’ holds significant promise for identifying optimal interventions ...
Breaking Biology Technology:Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5Grace Launches New REVELERIS® Prep Purification System 2Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2
... 20 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,ONC, ... has been granted,U.S. Patent 7,374,752 entitled "Reovirus ... claims cover pharmaceutical compositions,which comprise various recombinant ... with additional patent protection for,reovirus compositions in ...
... ... Annual Meeting, ... with asthma not adequately controlled on the inhaled,corticosteroid fluticasone propionate ... the equivalent dose of,FP combined with salmeterol administered as Advair ...
... Kosan Biosciences,Incorporated (Nasdaq: KOSN ) today ... Senior Vice President and Chief Medical Officer. Dr. ... and registration of cancer,therapeutics and has had a ... clinical pharmacologist, most notably at Novartis. Dr. Cohen,joins ...
Cached Biology Technology:Oncolytics Biotech Inc. Announces Issuance of 27th U.S. Patent 2Asthma Patients Not Adequately Controlled on ICS Alone More Likely to Benefit From Advair(R) Than Doubling the Dose of ICS 2Asthma Patients Not Adequately Controlled on ICS Alone More Likely to Benefit From Advair(R) Than Doubling the Dose of ICS 3Kosan Appoints Pamela S. Cohen, M.D., as Chief Medical Officer 2Kosan Appoints Pamela S. Cohen, M.D., as Chief Medical Officer 3Kosan Appoints Pamela S. Cohen, M.D., as Chief Medical Officer 4
... Serum is obtained from ... from healthy, fasted donors. The ... any way and are maintained ... Total Protein Concentration : ...
Hamster serum...
... Captiva 96-well Filter Plates are offered in ... 0.45 um depth filter plates are ideal ... analysis. Filtration is simple, versatile, and necessary ... The Captiva 10 um glass fiber and ...
... cDNA Labeling Kit with CyScribe GFX ... generation and purification of Cy3- and ... for complete cDNA labeling and purification.Flexible ... for performing labeling reactions with either ...
Biology Products: