Navigation Links
Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease
Date:4/16/2009

acity in the Brain of Female G93A Mice, An Animal Model of Amyotrophic Lateral Sclerosis (ALS) was conducted by Rajini Seevaratnam1 supervised by Mazen J. Hamadeh1,2 , and co-authored by Sandeep Raha2 and Mark A. Tarnopolsky2 (1School of Kinesiology and Health Science, York University, Toronto, ON, Canada; 2Department of Pediatrics and Medicine, McMaster University Hamilton, ON, Canada). The researchers will present their findings at the 122nd Annual Meeting of the American Physiological Society (APS; www.the-aps.org/press), which is part of the Experimental Biology 2009 scientific conference. The meeting will be held April 18-22, 2009 in New Orleans.

Study Design

Fifty-one G93A mice were randomly divided into eight groups: control (6 males, 8 females), coffee (5 males, 7 females), caffeine (5 males, 8 females), chlrogenic acid (5 males, 7 females). The control groups were fed a standard rodent diet and were not given any additional supplements. The intervention groups were provided with coffee, caffeine, and chlorogenic acid extracts, respectively, in amounts found in 5-10 cups of coffee per day, controlled for body weight.

Clinical measures: Food intake, body weight, body condition, ability to move, clinical score, and motor performance were all assessed for the effect of diet and time prior to animal sacrifice.

Molecular measures: Markers of oxidative stress (4-HNE; 3-NY), antioxidant enzyme protein content (MnSOD; CAT; GPx1; GR; GPx1 to GR ratio), and cell death (Bax; Bcl-2) were analyzed using the brains of these mice at age 108 days.

Statistical analysis was conducted for males and females separately.

At the end of the study, the researchers found that:

In males:

  • Coffee: increased food intake by 21%, decreased markers of oxidative stress by 39-65%, increased markers of antioxidant enzyme protein content by 46-139%, and decreased markers of cell death by 34-36%.
    '/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
703-967-2751
American Physiological Society
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A low dose of caffeine when pregnant may damage the heart of offspring for a lifetime
2. Post-exercise caffeine helps muscles refuel
3. Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
4. Gene therapy appears safe to regenerate gum tissue
5. Team approach appears to work best for insect colonies
6. Mars water appears to have been too salty to support life
7. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
8. Risk of common vaginal infection linked to preterm birth appears higher for blacks
9. Scripps research team solves structure of beneficial virus
10. Experts tackle shipment issues for beneficial radiation sources
11. Too much technology may be killing beneficial bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
(Date:3/20/2015)... 20, 2015 Research and Markets ... the "India Sensors Market Forecast and Opportunities ... The sensor market is projected to grow at ... Consumer electronics, automotive, industrial and healthcare sectors are ... country. In addition, adoption of MEMS technology in ...
(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... wallet is one of the products featured in 2015 ... 20th at 11:00 PM EST on the DIY Network. ... Las Vegas , site of the ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... study sheds new light on the role of carbon dioxide ... that instead of sinking, carbon dioxide is often consumed by ... dimly lit area 100 to 1,000 meters below the surface. ... it can be stored and prevented from re-entering the atmosphere ...
... for understanding life. DNA replication remains difficult to investigate ... double-membrane nucleus. However, the process is far easier to ... 40 (SV40), the large T-antigen protein (T-ag) is responsible ... the origin of replication. SV40 T-ag can also cause ...
... against amyloid-beta, the protein that forms plaques in the ... the brain from damage in early stages of the ... Hospital (MGH) researchers finds that lack of a protein ... led to increased amyloid-beta deposits and earlier death in ...
Cached Biology News:Ocean's 'twilight zone' may be a key to understanding climate change 2Blocking immune cell action increases Alzheimer's-associated protein deposits 2Blocking immune cell action increases Alzheimer's-associated protein deposits 3
(Date:4/27/2015)... 2015  MT Services LLC, a Lawsuit Settlement ... that U.S. District Judge Joseph Goodwin ... status meeting in hopes to resolve more than ... manufacturers who are involved in multidistrict litigations under ... going on for some time, and Judge Goodwin ...
(Date:4/25/2015)... Join us for a webinar at 12 ... Times using the Transcreener® ADP Assay , Register ... increasingly being incorporated into lead development efforts because longer ... increased therapeutic window and reduced side effects. Though ... such surface plasmon resonance, conjugation of drugs can affect ...
(Date:4/24/2015)... MN , April 24, 2015 /PRNewswire/ - BioAmber ... by Bayer MaterialScience as the supplier of bio-succinic ... innovative, bio-based polyurethanes for textile applications that Bayer ... MaterialScience has launched IMPRANIL ® eco, a ... content that reaches as high as 65%.  IMPRANIL ...
(Date:4/24/2015)... 2015 Seoul Semiconductor announced the ... applications in the lighting market. In recent ... this technology in emerging markets such as Russia, ... range of applications such as streetlight and area ... , First launched in 2005 the Acrich technology ...
Breaking Biology Technology:Transvaginal Mesh Lawsuit News: Another Joint Conference Status Meeting Ordered by Judge to Resolve More than 70K TVM Lawsuits against Several Mesh Manufacturers, Says Lawsuitsettlementnews.com 2Transvaginal Mesh Lawsuit News: Another Joint Conference Status Meeting Ordered by Judge to Resolve More than 70K TVM Lawsuits against Several Mesh Manufacturers, Says Lawsuitsettlementnews.com 3BellBrook Labs Webinar: Analyzing Kinase Inhibitor Residence Times using the Transcreener® ADP Assay 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2
... Genome,Sciences, Inc. (Nasdaq: HGSI ) announced today ... Phase 2 clinical trial of HGS-ETR1 (mapatumumab) in,combination ... therapy in patients with advanced non-small cell lung ... newly diagnosed with non-small cell,lung cancer have locally ...
... abuse treatment for teens and adults, HIGHLANDS RANCH, ... the expansion of its treatment services to,include a detox ... 17 as well,as adults, and the hospital has added ... dual diagnosis (substance abuse and,mental illness)., Teen suicide ...
... LifeCell,Corporation (Nasdaq: LIFC ), today announced ... 2008 financial guidance on Monday, January,7, 2008 at ... Executive,Officer, will host a conference call at 10:00 ... revenues and expected financial performance,for 2008., The ...
Cached Biology Technology:Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy 2Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy 3Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy 4Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy 5Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy 6Highlands Behavioral Health Hospital Unveils New Substance Abuse Detox Program 2LifeCell Corporation Schedules 2008 Financial Guidance Release and Conference Call; January 7, 2008 at 10:00 A.M. Eastern 2
...
... 1 Block MBS Start up kit. Includes ... and choice of 1 MultiBlock satellite ... 30 blocks. User friendly software. ... Adjustable height heated lid. Outstanding uniformity. ...
For relative and/or absolute quantification with standard accuracy requirements using MS or NMR instruments...
For testing the AQUA technique on your MS instruments....
Biology Products: