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Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
Date:5/26/2009

use colitis increases risk for this disease".

In summary, normalization of expression of CYP4B1, a drug metabolizing enzyme possibly related to reversal of inflammatory damage was a hallmark of the efficacy of caffeic acid, a component found widely in plant foods in the human diet, to inhibit intestinal tissue damage in a mouse model commonly used to simulate colitis. Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "The article by Hendrich and colleagues may help in the future design of more effective treatments to prevent or diminish colitis".


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Contact: Dr. Suzanne Hendrich
shendric@iastate.edu
515-294-4272
Society for Experimental Biology and Medicine
Source:Eurekalert

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