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CWRU receives $5 million from Ohio Third Frontier Commission
Date:6/25/2009

or devices to treat disease and injury. CSCRM, located in Northeast Ohio but collaborating state wide, is uniquely positioned to rapidly implement new stem cell technologies in the commercial and therapeutic arenas.

"I can see stem cells replacing drugs to improve many diseases," said Dr. Gerson. "Stem cells can replace injured cells, improve the function of many organs in the body and provide specific new functions to treat many diseases."

The Third Frontier funding will support the following commercial, emerging and pilot programs:

Commercial programs

The commercial projects are expected to generate significant near term value for the sponsoring companies and the State of Ohio.

  • Athersys and Kenneth Cooke (UHCMC and CWRU) will further evaluate MultiStem to cure immunological reactions to cell related therapies for cancer. The goal of this project is to advance the commercialization of MultiStem cell therapy by running a FDA approved Phase II clinical trial to evaluate the performance of the cells.

  • Juventas Therapeutics, spin out company from Marc Penn (CC), will develop its lead drug product, stromal cell derived factor 1 (SDF-1), through a Phase I clinical trial for critical limb ischemia.

Emerging programs

With further refinement of already established proof of concept, the following programs could mature into significant opportunities for CSCRM and the region.

  • Dr. Gerson is partnering with Lentigen, Inc, of Gaithersburg, MD to develop a gene therapy approach to treating brain tumors.

  • Jean Welter (CWRU) and Adam Lambert (Oakwood Laboratories) are teaming up to develop a combination product comprised of a drug and Oakwood's proprietary sustained release technology to treat arthritic disease.

  • Eben Alsberg (CWRU) and Orthopediatrics of Warsaw, IN will use microspheres tuned to release a specific amount of drug ove
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Contact: Christina DeAngelis
cat41@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

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