Navigation Links
CWRU receives $2.1 million NIH grant to expand cystic fibrosis research models
Date:7/26/2011

lan to generate even more of these basic research models.

The models developed thus far include mice with different versions of the CF gene, each with a different amount of function, so that researchers can determine the critical levels of the gene function for the manifestation of any disease-related characteristic.

Recently, these researchers generated models that allow them to turn the CF gene on or off in different organs of the body, or at different times in the life of the animal. Turning the gene off enables researchers to determine how the gene directly and indirectly affects different organs, while turning it on allows researchers to assess the effects of correcting the CF gene. Their work with these mice has shown that the effects of the disease on the lungs and digestive system are more complex than originally thought, involving not only the cells lining those organs, but also the immune system and other types of cells. One of the apparent ramifications is that there may be targets for therapy not previously considered.

"Our hope is that we'll find out where in the body and when we need to focus our attention for therapies. This is a devastating disease for the children affected by it, and for their families, so anything we might do to improve the health of these kids would be of great significance."


'/>"/>

Contact: Christina DeAngelis
cat41@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
3. Kount Receives Patent for Device Fingerprinting
4. American College of Medical Genetics receives $13.5M NIH contract
5. Penn State receives new NASA astrobiology grant
6. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
7. Vidaza receives positve opinion from European CHMP
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. Montana State partnership receives $66.9M for carbon sequestration
10. Oklahoma EPSCoR receives $20 million for biofuels research
11. UC Riverside rice geneticist receives high honor from US Department of Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/11/2014)... associate professor of mechanical engineering at Worcester ... the university,s Integrative Materials Design Center (iMdc), ... the National Science Foundation (NSF) to support ... manufacture metal-ceramic composites, which can be used ... efficient, while significantly increasing their performance. , ...
(Date:9/11/2014)... , Sept. 11, 2014 /PRNewswire-iReach/ -- Today at the ... a patient portal that puts genome sequencing results at ... useful and actionable. The $1000 was announced ... many to be the tipping point towards widespread adoption ... 6 billion letters and 4 million variants per human ...
(Date:9/11/2014)... has estimated the total mass of oil that reached the ... Deepwater Horizon blowout. It,s the first time such an estimate ... issue of Environmental Science and Technology . , ... Gulf shoreline in 2010. This finding will help officials determine ... harm to the ecosystem. , The study was conducted by ...
Breaking Biology News(10 mins):NSF funds new method for making materials that can make lighter, more efficient vehicles 2NSF funds new method for making materials that can make lighter, more efficient vehicles 3Tute Genomics Launches MyGene Portal for Genome-guided Medicine 2Tute Genomics Launches MyGene Portal for Genome-guided Medicine 3NJIT researchers working to safeguard the shoreline 2
... a person this is the greatest of pleasures. But, in ... beer as it is among the most energy-intensive foodstuffs during ... working hard to improve the energy balance of the amber ... would allow energy savings of up to 20% during brewing. ...
... pollution, or smog, is a highly reactive, colorless gas ... pollution is most often associated with outdoor air, the ... Ozone can be released by ordinary copy machines, laser ... all of which contribute to increased indoor ozone levels. ...
... Researchers in Australia are developing diversionary tactics to ... those responsible for major gut infections, such as cholera, ... to complex sugar receptors displayed on the surface of ... Society for General Microbiology,s meeting at Heriot-Watt University, Edinburgh, ...
Cached Biology News:Environmentally 'green' beer: Munich brewing engineers research energy savings 2Environmentally 'green' beer: Munich brewing engineers research energy savings 3Houseplants cut indoor ozone 2Designing probiotics that ambush gut pathogens 2
(Date:9/11/2014)... Until recently, pets suffering from arthritic ailments ... their pain. Pill therapies are costly, can be harmful ... , The procedure uses adult (not embryonic) animal ... regenerative healing power. MediVet's equipment enable veterinarians to remove ... stem cells, then activate and inject the cells into ...
(Date:9/11/2014)... 11, 2014  Ikonopedia will showcase its new ... imaging reporting modules here at the Intensive Breast ... Ikonopedia,s revolutionary suite of report generation software tools ... they look like rather than what they are ... reporting efficiency, and optimize facility operations.  ...
(Date:9/11/2014)... Florida (PRWEB) September 11, 2014 Central ... to announce his partnerships with several Brevard County animal ... Dr. Christiansen has been working in the area since ... small animals since 2008, and is happy to now ... the years Dr. Christiansen has used stem cell therapy ...
(Date:9/10/2014)... Jersey (PRWEB) September 11, 2014 ... its annual Innovations in Dermatological Sciences conference Oct. ... focus on how the university, industry and government ... into clinical use. , This conference is unique ... with cross-sector collaboration, to share their successes, best-practices, ...
Breaking Biology Technology:MediVet America Secures Exclusive Worldwide License with Nanofiber Veterinary 2Ikonopedia Showcases New MQSA Management System and Reporting Modules at Intensive Breast Ultrasound Meeting 2Ikonopedia Showcases New MQSA Management System and Reporting Modules at Intensive Breast Ultrasound Meeting 3Dr. Jeff Christiansen is Now Offering Stem Cell Therapy for Pets at Five Brevard County Animal Hospitals and Beyond 2Dr. Jeff Christiansen is Now Offering Stem Cell Therapy for Pets at Five Brevard County Animal Hospitals and Beyond 3Innovations in Dermatological Sciences 2014 2Innovations in Dermatological Sciences 2014 3
... BioCryst,Pharmaceuticals, Inc. (Nasdaq: BCRX ) today announced that ... will present,a corporate update at the JMP Healthcare Focus ... 10:00 a.m. Eastern Time., A link to a ... accessed on,the BioCryst Web site http://www.biocryst.com . The ...
... Second FDA Cleared Diagnostic Test in 2008; Test, Improves Time-to-Result by ... ... Methods, SUNNYVALE, Calif., Oct. 1 Cepheid (Nasdaq:,CPHD) today announced ... market its Xpert(TM) MRSA/SA Blood Culture (BC),test, which runs on the GeneXpert(R) ...
... Limited,(LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company,announces ... General,Meeting on September 24, 2008, the Company has changed ... Shire plc,s ticker symbols on the London Stock Exchange ... shares and American Depositary,Shares will remain unchanged., Notes ...
Cached Biology Technology:BioCryst to Present at the JMP Healthcare Focus Conference 2BioCryst to Present at the JMP Healthcare Focus Conference 3Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures 2Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures 3Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures 4Cepheid Receives FDA Clearance for First On-Demand Diagnostic Test for Life-Threatening MRSA and Staphylococcus aureus From Patient Positive Blood Cultures 5
Anti-Indolamine (Indoleamine) 2,3-dioxygenase Immunogen: Recombinant human IDO. Available Date: 38454...
Anti-Ephrin B1 Host: rabbit polyclonal Species Reactivity: human Applications: WB Storage: 4C...
Human Regulatory T cell Staining Kit #2 (w/ APC Foxp3 PCH101, FITC CD4, PE CD25)...
...
Biology Products: