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CWRU receives $2.1 million NIH grant to expand cystic fibrosis research models
Date:7/26/2011

lan to generate even more of these basic research models.

The models developed thus far include mice with different versions of the CF gene, each with a different amount of function, so that researchers can determine the critical levels of the gene function for the manifestation of any disease-related characteristic.

Recently, these researchers generated models that allow them to turn the CF gene on or off in different organs of the body, or at different times in the life of the animal. Turning the gene off enables researchers to determine how the gene directly and indirectly affects different organs, while turning it on allows researchers to assess the effects of correcting the CF gene. Their work with these mice has shown that the effects of the disease on the lungs and digestive system are more complex than originally thought, involving not only the cells lining those organs, but also the immune system and other types of cells. One of the apparent ramifications is that there may be targets for therapy not previously considered.

"Our hope is that we'll find out where in the body and when we need to focus our attention for therapies. This is a devastating disease for the children affected by it, and for their families, so anything we might do to improve the health of these kids would be of great significance."


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Contact: Christina DeAngelis
cat41@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

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