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CWRU receives $2.1 million NIH grant to expand cystic fibrosis research models
Date:7/26/2011

CLEVELAND July 26, 2011 Case Western Reserve University School of Medicine has received a $2.1 million grant from the National Center for Research Resources, part of the National Institutes of Health (NIH), to expand basic research models for the study of cystic fibrosis (CF).

CF is an inherited disease that causes thick, sticky mucus to build up in the lungs and digestive tract. The four-year NIH grant was awarded to Mitchell Drumm, PhD, and Craig Hodges, PhD, co-investigators of the research supported by the grant.

Drumm is professor of Pediatrics and Genetics at the Case Western Reserve School of Medicine, and vice chair for research in Pediatrics. He co-discovered the gene that causes CF, CFTR, along with Francis Collins, MD, PhD, the noted physician-geneticist and current director of the NIH. Hodges is an assistant professor of Pediatrics and Genetics at the Case Western Reserve School of Medicine as well.

Together, Drumm and Hodges have developed and studied a series of basic research models that have contributed significantly to the research community's understanding of CF and examined the effects of correcting the genetic defect in CF using these models. The newly secured grant provides the researchers the resources necessary to advance CF research through the development of additional basic research models.

"Basic research is critical in helping investigators pinpoint the cellular and molecular mechanisms that cause CF in order to determine how they can be reversed," Drumm said. "As there are currently a number of therapeutic approaches designed to correct CF gene function, it is important to understand what aspects of the disease can be corrected, or even reversed."

Such research entails the study of mouse genetics to better understand CF. Drumm and Hodges co-direct an animal core facility with the most comprehensive collection of CF mouse models in the world. With the new NIH grant, Drumm and Hodges p
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Contact: Christina DeAngelis
cat41@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

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