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CWRU dental researchers discover human beta defensins-3 ignite in oral cancer growth
Date:7/13/2010

tion its role on tumor growth and found it attracts other molecules that actually help the cancerous tumor grow and eventually spread to other parts of the body.

It appears hBD-3 plays a role in the development of the chemokine receptor called CCR2 that recruits tumor-associated macrophage cells to infiltrate the tumor site and stimulate tumor growth. The tumor-associated macrophages and other molecules release growth factors that encourage the progression of the tumor. Eventually tumor cells break away, travel and spread the cancer to other places in the body.

"This is the first time that we have evidence that CCR2, too, has a role in oral cancer growth," said Jin.

The researcher plans to continue studying the role of hBDs in oral health and to develop diagnostic tools that use the biomarker to detect early cancer.


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Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

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