Navigation Links
CWRU dental researcher's NIDCR grant targets oral bacteria and fetal death link
Date:7/8/2013

A new four-year, $1.58 million grant from the National Institute of Dental and Craniofacial Research, will allow a Case Western Reserve University School of Dental Medicine researcher to advance her work linking oral bacteria to fetal death.

The grant will support a study by Yiping Han, professor of periodontics that focuses on the prevalent oral bacteria, Fusobacterium, and several of its subspecies. The bacteria keeps the mouth's natural disease defenses working, but can also cause diseases when they enter the bloodstream and travel throughout the body, including the placenta, umbilical cord and fetus.

In prior research, Han has linked the bacteria to stillbirth, post-birth sepsis and premature births due to inflammation in the placenta, which is supposed to be bacteria-free.

Of Fusobacterium's five subspecies, two have mechanisms that allow them to leave the mouth and travel to other parts of the body, including the placenta.

"We are interested in why more of some subspecies are found in the uterus and placenta, but others never leave the mouth," Han said. "We have to find out why, and then stop them."

Until they have an answer, Han urges everyonenot just pregnant womento maintain their oral health.

In another recent study, Han and Xiaowei Wang, postdoctoral scholar in Han's lab, found that atherosclerotic disease, adverse pregnancy outcomes, rheumatoid arthritis, inflammatory bowel disease, colorectal cancer and respiratory tract infections all had oral bacteria connections.

"Almost every disease in research literature reviewed has the presence of Fusobacterium at the diseased site," Han concluded in the study.

About 700 species of bacteria live in the mouth, according to Han. Some will never leave that environment. But others, like Fusobacterium, have developed the ability to slip between cells in blood vessel walls to enter the blood and establish "colonies" in various parts of the bodywhich Han has described as a key that opens the door, allowing other oral bacteria in.

Once a colony is established, Han explained, it triggers the biochemical process that creates inflammation that can develop into plaque in the heart, erosion of the bone in arthritis or bacteria in the lungs that can cause a newborn's death.

Fusobacterium also have a mechanism to attach to cell walls and set the body's immune response in motion.

Once the bacteria cause inflammation, the researchers said, they become bona fide pathogens that incite diseases.

Han, who has researched oral bacteria's link to adverse pregnancy outcomes for a decade, has made a number of discoveries over the years.

By using DNA tracking, she has linked the bacteria found in a stillborn baby to plaque in the mother's mouth. In mouse models and cord blood from human babies, Han used new DNA testing to discover many more oral bacteria are present in the placenta, amniotic fluid and cord blood than previously thought. Many of these bacteria cannot be found with traditional culture testing of amniotic fluid or blood.

The ability to identify and properly treat the bacteria could potentially prevent diseases and save lives, Han said.


'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Surge in children accidentally eating marijuana-laced foods
2. Accidental discovery may lead to improved polymers
3. ACMG releases report on incidental findings in clinical exome and genome sequencing
4. Measuring mercury: Common test may overestimate exposure from dental amalgam fillings
5. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
6. Dental X-rays linked to common brain tumor
7. UCLA researchers find new clue to cause of human narcolepsy
8. Researchers discover new way to block inflammation
9. Researchers call for rethinking efforts to prevent interplanetary contamination
10. Northwestern researchers examine mechanical bases for the emergence of undulatory swimmers
11. Researchers determine factors that influence spinach contamination pre-harvest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... Summary This report provides all ... and its partnering interests and activities since 2010. ... The Partnering Deals and Alliance since 2010 report provides ... of the world,s leading life sciences companies. ... ensure inclusion of the most up to date deal ...
(Date:2/28/2017)... , Feb. 28, 2017   Acuant , ... software globally, announces significant enhancements to new and core ... 2016. New products include mobile and desktop Acuant FRM ... TM - a real time manual review of ... idScan® technology provides the fastest and most accurate capture ...
(Date:2/26/2017)... Feb. 25, 2017  Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring, announces ... Reentry. "Too often, too many offenders ... county jails are trying to tackle this ongoing ... friends and family members. While significant steps are underway, ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... ... March 27, 2017 , ... A ... and customizable vascular grafts in JoVE’s Video Journal, the world’s first peer-reviewed scientific ... improved ways of treating coronary artery disease (CAD). Lam is an assistant professor ...
(Date:3/24/2017)... MiMedx Group, Inc. (NASDAQ: MDXG), the leading ... allografts and patent-protected processes to develop and market advanced ... today  that it will present at the Needham Healthcare ... Parker H. "Pete" Petit, Chairman and CEO, Michael ... Cashman , EVP and Chief Commercialization Officer, and ...
(Date:3/24/2017)... On Thursday, March 23, 2017, ... down 0.07%; the Dow Jones Industrial Average edged 0.02% ... closed at 2,345.96, marginally dropping 0.11%. US markets saw ... 4 sectors finished in red, and 1 sector ended ... reports coverage on the following Biotechnology equities: BioDelivery Sciences ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... Lajollacooks4u is proud to announce it has ... has hosted corporate cooking challenges for companies around the world, such as Illumina, HP and ... of the reason for its increasing popularity is due to its new team building format, ...
Breaking Biology Technology: