Navigation Links
CWRU School of Medicine has evidence vaccine against malaria will reduce disease
Date:12/20/2007

CLEVELAND December 20, 2007 Researchers at the Case Western Reserve University School of Medicines Center for Global Health & Diseases published data potentially impacting the three billion people exposed to malaria every year. Brian T. Grimberg, Ph.D., Peter A. Zimmerman, Ph. D., and Christopher L. King, M.D., Ph.D. published in the December issue of Public Library of Science Medicine (PLoS Medicine), novel findings proving new antibodies inhibit infection by the Plasmodium vivax (P. vivax) malaria parasite. The research suggests a Duffy binding protein-based vaccine could provide protection against malaria blood-stage infection. This specific protein is an attractive candidate for a P. vivax vaccine, as it could decrease illness in malaria prevalent regions. For the first time, scientists from the eight partner institutions along with the Center for Global Health & Diseases, conclusively proved that invasion of human red blood cells by the malaria parasite could be prevented by these antibodies.

Unlike other types of malaria, a P. vivax infection relies solely upon the single molecular interaction between the Duffy antigen on human red blood cells and the Duffy binding protein expressed by the parasite to establish the disease. By interrupting the interaction of parasite binding to the red cell, the researchers and their colleagues around the United States and in Papua New Guinea, India, and Thailand, have the potential to eliminate P. vivax malaria. By exploiting this required interaction, the research offers a clear path toward development of a P. vivax malaria vaccine.

James W. Kazura, M.D., Director of the Center for Global Health and Diseases at Case Western Reserve University emphasized P. vivax is widely distributed throughout Asia, the South Pacific, parts of Africa, and South America. However, the importance of developing a P. vivax vaccine to the American public is underscored by the fact that this is the form of malaria most frequently transmitted in Afghanistan, Iraq, and adjoining regions where United States troops are currently stationed.

For more than 50 years the Case Western Reserve School of Medicine has dedicated significant effort to the field of international health. This emphasis was initiated by the late Frederick C. Robbins, M.D., Dean of the School of Medicine from 1966 to 1980, and Nobel Laureate for discovering methods that led to development of the polio vaccine.

Malaria, deemed one of the worlds big three diseases, along with tuberculosis and HIV/AIDS, kills one million people every year. There are currently 70 million cases of P. vivax worldwide. The diseases prevalence has increased in recent years through the worldwide spread of drug resistance, which is why a vaccine is desperately needed. This Case Western Reserve University School of Medicine research is particularly encouraging because it offers one of the first feasible vaccine concepts for the most common form of malaria.


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. Rutgers high school outreach gets $3 million boost from NSF
3. UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC
4. Folic acid lowers blood arsenic levels, according to Mailman School of Public Health study
5. UMass Medical School researchers receive $8.5M grant award to fight AIDS
6. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
7. Kids eat more fruits, vegetables when schools offer salad bar
8. New research seeks to enhance quality and security of wireless telemedicine
9. Penn Veterinary Medicine report new strategy to create genetically-modified animals
10. SNM applauds NAS study showing need to restore federal nuclear medicine research funding
11. Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... With ... microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical Services. ... range of contract analysis services for advanced applications. Services will leverage techniques ...
Breaking Biology Technology: