Navigation Links
CU researchers explain mechanism that helps viruses spread
Date:6/9/2014

AURORA, Colo. (June 9, 2014) In an article published in the scientific journal Nature, a University of Colorado School of Medicine researcher and colleagues explain how RNA molecules found in certain viruses mimic the shape of other molecules as part of a strategy to 'hijack' the cell and make more viruses.

The findings by Jeffrey S. Kieft, PhD, associate professor of biochemistry and molecular genetics at the School of Medicine and an early career scientist with the Howard Hughes Medical Institute, and his colleagues solve a biochemical and molecular mystery that has confounded scientists for decades.

Viruses are worldwide threats to health and agriculture. To multiply, viruses infect a cell and take over that cell's biochemical machinery. Thus, understanding the fundamental molecular processes used by viruses to conquer cells is important. Among these processes is the ability of molecules created by viruses to 'mimic' the structure and behavior of cellular molecules. The virus' molecular 'Trojan horses' are part of their strategy to take over cells.

The paper describes the three-dimensional structure of a viral RNA that mimics one of the most abundant RNAs found in the cell. It was known for many years that this viral RNA was a molecular mimic. However, how the RNA acts as a mimic, how it switches between different structures, and how it performs multiple tasks was a mystery.

Using a technique called x-ray crystallography, Kieft and colleagues visualized the molecule's complex three-dimensional structure to high resolution. They found that the viral RNA has a 'two-faced' architecture: one face is a mimic of the cell's RNA, the other face is less similar and this probably gives the ability to perform several tasks during infection. This type of behavior may be widespread, thus this research could apply to many different viruses.

This understanding of how a viral RNA can mimic other molecules as part of
'/>"/>

Contact: Mark Couch
mark.couch@ucdenver.edu
303-724-5377
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... virus is spreading rapidly and to an unexpected extent. ... the past and the virus shows a new disease ... before. For this reason, the German National Academy of ... and Engineering, and the Union of the German Academies ... the Ebola epidemic today. , In the statement the ...
(Date:10/15/2014)... , Oct. 15, 2014   Neurotechnology , ... announced the availability of the VeriLook Surveillance ... 3.0 provides real-time biometric face identification using live ... surveillance cameras. The new version not only identifies ... people from objects while they are moving through ...
(Date:10/14/2014)... have sequenced the house fly genome for the first ... from an insect that thrives in pathogen-rich dung piles ... in the journal Genome Biology , will increase ... how flies quickly adapt to resist insecticides, which could ... (Musca domestica) carry and transmit more than 100 human ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2
... A prototype scanner aboard the international space station has been ... months since it was launched, providing scientists with a new ... from oil spills to plankton blooms. The images and ... world through an online clearinghouse coordinated by Oregon State University. ...
... This press release is available in German . ... exacerbates the estimation of population sizes. However, the monitoring of ... to quick and effective conservation action. Scientists from the Max ... of male and female parti-colored bats ( Vespertilio murinus ) ...
... Diabetes type 2 is caused by insufficient levels of insulin ... hormone, glucagon, can also contribute to diabetes type 2 by ... Diabetes type 2 does not arise overnight, but slowly progresses ... prediabetes, blood sugar rises to excessive levels after a meal, ...
Cached Biology News:Data streaming in from Space Station to OSU lab 2Data streaming in from Space Station to OSU lab 3Bats keep separate households 2Bats keep separate households 3A diabetes drug, sitagliptin, also has a potential to prevent diabetes 2
(Date:10/20/2014)... , Oct. 20, 2014 Asterias Biotherapeutics, ... Company has signed a Notice of Grant Award ... (CIRM), effective October 1, 2014.  The NGA provides ... and the release of additional grant funds pursuant ... award for clinical development of Asterias, product, AST-OPC1. ...
(Date:10/20/2014)... October 20, 2014 OncLive® ... Kimmel Cancer Center at Thomas Jefferson University has ... Through the Strategic Alliance Partnership program, the Sidney ... collaborate to raise awareness of the Center’s cutting-edge ... other projects. Clinicians and other health care professionals ...
(Date:10/19/2014)... NextCODE Health, which enables clinicians and researchers to ... today announced the launch of its new genomic data analysis ... American Society of Human Genetics (ASHG) annual meeting in ... and apply for free beta access, visit www.nextcode.com . ... be viewed here . The Exchange: ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems ... analysis and forecast of revenue. The Orthopedic braces and support ... $416.5 million by 2018, at a developing CAGR of 4.4% ... the Asian Orthopedic braces and support systems market, to get ... a glimpse of the segmentation of orthopedic braces and support ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
... data quality firm Firstlogic for about $69 million ... second quarter. , ,Firstlogic is a privately held firm that ... sure their data is as correct as they need to ... call centers, web sites, customer relationship management systems, and business ...
... undergrad engineering contest was swept this year by a ... that concentrates the sun's rays. , ,Angie Franzke's concentrating ... the Schoofs Prize for Creativity and the Tong Prototype ... many current solar systems use to collect energy, Franzke ...
... , an HMO in south-central Wisconsin with about 100,000 ... , in Richmond, Virginia, to provide benefits information to ... access their personal pharmacy claims histories via the Internet. ... the therapeutic alternatives available in that class as well ...
Cached Biology Technology:Concentrated solar energy project wins Innovation Days prizes 2
... Competitor Assay Kits are ideal for ... binding compounds using fluorescence polarization (FP). ... of glutathione transferase to the ligand ... [PR-LBD(GST)] and a proprietary, fluorescently tagged ...
... is critical to the maintenance of ... proteins as important and diverse as ... shock and stress response, antigen presentation, ... ion channels, cell cycle regulation, transcription, ...
... The RapidVUE is a particle shape and size ... been designed with the utmost simplicity in mind. ... delivery module and an optical bench. The system ... for easy upgrade for different applications such as ...
... Serum-Single Donor • Human serum is obtained ... to be negative by a test for ... to Human Immunodeficiency Virus (Anti-HIV 1/2), Hepatitis ... B Surface Antigen (HbsAg) and Non-reactive by ...
Biology Products: