Navigation Links
CU-led team receives $9.2 million DOE grant to engineer E. coli into biofuels
Date:12/4/2012

A team led by the University of Colorado Boulder has been awarded $9.2 million over five years from the U.S. Department of Energy to research modifying E. coli to produce biofuels such as gasoline.

"This is a fantastic opportunity to take what we have worked on for the past decade to the next level," said team leader Ryan Gill, a fellow of CU-Boulder's Renewable and Sustainable Energy Institute, or RASEI. "In this project, we will develop technologies that are orders of magnitude beyond where we are currently."

The team is working with a non-pathogenic strain of E. coli. Among the microbe's more than 4,000 genes, the team is searching for a small set and how it can be manipulated in a combination of on and off states to change the bacteria's behavior.

"E. coli is not going to want to make your biofuel at all," said Gill, who's also a CU-Boulder associate professor of chemical and biological engineering. "It doesn't do that naturally. It's programmed with thousands of genes controlling how it replicates. We're figuring out what control structure we need to rewire in the bug to make it do what we want, not what it wants."

Included in the team are Rob Knight, CU-Boulder associate professor of chemistry and biochemistry; Pin-Ching Maness, principal scientist at DOE's National Renewable Energy Laboratory, or NREL; and Adam Arkin, physical biosciences director at DOE's Lawrence Berkeley National Laboratory.

The researchers hope to engineer the production of ethylene and isobutanol in the modified E. coli. The two compounds are widely used commodities that can be converted into gasoline among other chemicals.

The greatest challenge is harnessing an efficient and inexpensive process that competes with abundant and low-cost fossil fuels like oil, according to Gill.

"Microorganisms and their genomes are incredibly complex machines," said Gill. "The first step alone -- of
'/>"/>

Contact: Ryan Gill
rgt@colorado.edu
303-492-2627
University of Colorado at Boulder
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Degraded military lands to get ecological boost from CU-led effort
2. Social factors trump genetic forces in forging friendships, CU-led study finds
3. University of Chicagos Graeme Bell receives international diabetes prize
4. WHOI scientist receives marine microbiology initiative investigator award from Moore Foundation
5. U of Minn. receives $1.8 million grant for improving efficiencies in fuel and plastics production
6. NJIT civil engineer receives NSF grant to study storms impact on Jersey Shore
7. NAS receives $350 million endowment from BP settlement with the federal government
8. UC Riverside receives 3 grants to assist graduate students in pursuing doctoral degrees
9. UConn receives Grand Challenges Explorations Grant for research in global health and development
10. Baylor University scientist receives major grants for health research on 1991 Gulf War veterans
11. Carnegie Institution for Science receives Grand Challenges Explorations grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... (NLST) investigators also conclude that the 20 percent ... tomography (LDCT) versus chest X-ray (CXR) screening previously ... at experienced screening centers in the United States. ... with their patients about the benefits and risks ... in the New England Journal of Medicine ...
(Date:5/22/2013)... must join together in a major new effort to ... in providing Earth,s people with clean water that looms ... a comment article in the current edition of ... the American Chemical Society (ACS), the world,s largest scientific ... Ph.D., and Jerald L. Schnoor, Ph.D., explain that shortages ...
(Date:5/22/2013)... human health effects from disposal of millions of ... to recommend stronger government policies to encourage recovery, ... That,s the conclusion of a new paper in ... . , Oladele A. Ogunseitan and colleagues point ... powering everything from smart phones to components in ...
Breaking Biology News(10 mins):NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 2NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 3
... a vital link in the chain of events that gives ... Wellcome Trust Centre for Stem Cell Research at the University ... process that gives embryonic stem cells their unique ability to ... the body (from liver cells to skin cells). Their findings, ...
... MADISON Success in soccer sometimes comes with "bending ... occurs at the moment of conception and when nerve ... bent before the merging process can begin, University of ... first concrete evidence that a protein called synaptotagmin plays ...
... protein production, a Princeton-led team has discovered why certain ... they also have discovered how one protein protects against ... In a study appearing in the Aug. 7 ... Princeton,s Warner-Lambert Parke-Davis Professor of Molecular Biology, and Johna ...
Cached Biology News:Switching on the power of stem cells 2A new 'bent' on fusion 2Princeton team learns why some drugs pack such a punch 2Princeton team learns why some drugs pack such a punch 3
(Date:5/21/2013)... (PRWEB) May 21, 2013 Alpha ... distributor , will be exhibiting for the 13th ... of Medical Instrumentation (AAMI) 2013 Conference and Expo. ... support, distribute, and manufacture healthcare technologies. This year’s ... Long Beach, California. , The three-day event ...
(Date:5/21/2013)... Raleigh, NC (PRWEB) May 21, 2013 ... and financial services company for clinical trials, announced ... Aggregate Spend Solutions, LLC. Clinverse’s ClinPay® FLS ... automated investigator payment process. SpendMD ™, ... only complete solution for tracking and reporting transfer ...
(Date:5/21/2013)... Toronto, Canada (PRWEB) May 21, 2013 ... there is a strong push within the industry ... Development and Manufacturing Organizations and pharma companies often ... time frames. , Microtablets, developed in collaboration with ... how effective outsourcing can bring products to market ...
(Date:5/21/2013)... 2013  MacroGenics, Inc. today announced that an ... an Fc-modified chimeric monoclonal antibody (MAb), in patients ... will be presented at the 2013 Annual Meeting ... the Developmental Therapeutics - Immunotherapy Oral Abstract Session ... PM.  The presentation will describe the results of ...
Breaking Biology Technology:Alpha Source, Inc. to Exhibit at the AAMI 2013 Conference and Expo 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3The Development of an Innovative Microtablet Dosage Form, a Success Story: Live Webinar Hosted by Xtalks 2MacroGenics Announces Margetuximab (MGAH22) Phase 1 Data Presentation at ASCO; Initiates Phase 2 Clinical Study to Evaluate Activity of Margetuximab in Patients with Metastatic Breast Cancer 2MacroGenics Announces Margetuximab (MGAH22) Phase 1 Data Presentation at ASCO; Initiates Phase 2 Clinical Study to Evaluate Activity of Margetuximab in Patients with Metastatic Breast Cancer 3
... The Wisconsin Technology Council is taking applications for the ... quite likely hundreds of them will vie ... two years' grand-prize winners have been life-science companies, but ... and information technology. , ,All 2004 and 2005 finalists ...
... statewide online high-school program may close unless administrators can ... on initial expectations, the Milwaukee Journal-Sentinel reports. ... for the Waukesha school district where it is operated ... to have a net loss of $1.2 million by ...
... place this past week at the University of Chicagos Gleacher ... the meeting was an opportunity to hear from four individuals, ... meetings in different cities, as a preview to what we ... Biotechnology meeting comes to Chicago in April, 2006. , ,Some ...
Cached Biology Technology:The legacy of BIO 2006, what it will be and how we need to plan for it now 2The legacy of BIO 2006, what it will be and how we need to plan for it now 3The legacy of BIO 2006, what it will be and how we need to plan for it now 4The legacy of BIO 2006, what it will be and how we need to plan for it now 5The legacy of BIO 2006, what it will be and how we need to plan for it now 6
Peptide-affinity Purified Polyclonal Antibody to MAML1 / Mastermind Peptide with sequence VLPTCPMAEFALPR, from N Terminus of the protein sequence according to NP_055572....
Mouse monoclonal [5H9] to RAD52 ( Abpromise for all tested applications). entrezGeneID: 5893 SwissProtID: P43351...
... belongs to the family of calcium binding proteins ... is composed of an alpha and beta chain ... S100 protein is also expressed in the ... in skin and interdigitating reticulum cells in the ...
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Biology Products: