Navigation Links
CU-Boulder worm study sheds light on human aging, inherited diseases
Date:10/1/2007

se.

For nearly a decade, scientists have experimented with RNA interference, or RNAi, technology to reduce gene expression with an eye toward learning more about human disease, Rea said. The technique is an effective way to silence specific pieces of DNA -- the genetic material that makes up the basic building blocks of life -- in living organisms, he said.

Rea and his team used RNAi to produce worms with varying levels of mitochondrial dysfunction with the hope of solving a mystery that has baffled scientists for years. They wanted to know why the genetically engineered worms, known as "Mit mutants," lived longer despite cellular defects that would have caused similarly damaged human cells to become diseased or die off in the lab.

The team concluded that long life occurs in worms only when energy production by their mitochondria is reduced to very discrete levels. "By tweaking cells into that tight little window of high efficiency, we may be able to increase the life span and health span of both sick and healthy people," Rea said.

The research suggests that the worms' cells receive signals from their nuclei as DNA problems are sensed and not, as previously thought, from their disrupted mitochondrial power sources. The signal-sending nuclei order cells to shut down DNA replication, allowing them time to fix problems and create an environment that copes better with DNA damage and stress, researchers believe.

"It is only in this window that survival is enhanced. Once you move too far outside, then, like human cells, worm cells also die," Rea said. "We think there's a whole shift in the metabolism and the way it protects DNA. We show very clearly in our work that long life is intimately linked with the control of cell division."

The process appears to mimic the "hunker down" survival mode that stressed animals adopt during times of famine and danger. When conditions improve, the animals procreate again to en
'/>"/>

Contact: Shane Rea
srea@colorado.edu
303-492-2505
University of Colorado at Boulder
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Morning grogginess more debilitating than sleep deprivation, according to CU-Boulder study
2. Bioartificial kidney under study at MCG
3. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
4. W.M. Keck Foundation funds study of friendly microbes
5. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
6. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
7. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
8. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
9. Study Links Ebola Outbreaks To Animal Carcasses
10. Genome-wide mouse study yields link to human leukemia
11. Breakthrough Microarray-based Technology for the Study of Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... LAKES , N.J. and NEW YORK ... Company) and Guidepoint today announced BD ... start-up healthcare companies with free access to Guidepoint,s expert ... several start-ups that are developing cutting-edge technologies to improve ... a dedicated Guidepoint research manager, each start-up entrepreneur will ...
(Date:7/7/2015)... MOUNTAIN VIEW, Calif. , July 7, 2015 ... mobile biometrics market, Frost & Sullivan recognizes Credence ... & Sullivan Entrepreneurial Company of the Year ... product suite to aid in its mission of ... and under-recognized populations globally. As Credence ID was ...
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... detected from space for the first time using optical ... aboard Envisat. The ability to monitor Sargassum globally will ... the ocean and better predict climate change. Credit: ESA ... ships in its dense floating vegetation, has been detected ...
... are moving closer to understanding why the most lethal ... treatment in the past three decades. They have been ... a protozoan gene that contributes to such resistance. And ... constructed over a two-year period is believed to be ...
... postdoctoral fellow at the University of Oregon, has shown that ... soil bacteria needed to provide a natural fertilizer to crops. ... boost crop yields may instead be contributing to growth problems, ... years of research both in the test tube and, now, ...
Cached Biology News:Envisat captures first image of Sargassum from space 2Largest synthetic gene ever built offers insights into anti-malarial drug resistance 2Largest synthetic gene ever built offers insights into anti-malarial drug resistance 3Largest synthetic gene ever built offers insights into anti-malarial drug resistance 4Pesticides choke pathway for nature to produce nitrogen for crops 2Pesticides choke pathway for nature to produce nitrogen for crops 3
(Date:7/29/2015)...  HealthSouth Corporation (NYSE: HLS ), one ... services, offering both facility-based and home-based post-acute services, ... second quarter ended June 30, 2015. ... growth in both segments and an 11.0% increase ... and Chief Executive Officer of HealthSouth. "While reported ...
(Date:7/29/2015)... 29, 2015 Research ... addition of the "Global Biosimilars Market, 2015 ... The Global Biosimilars Market, 2015 - 2025, ... growing biosimilars market. With the blockbuster biologics losing ... costs, biosimilars are being viewed as viable substitutes ...
(Date:7/29/2015)... YORK , July 29, 2015  Therapath ... testing, announces increased partnerships with VA and Military ... Epidermal Nerve Fiber Density (ENFD) and Sweat Gland ... small fiber neuropathy ( https://therapath.com/skin ). ... Nerve Fiber Density (ENFD) on punch skin biopsy ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... The third ... of combination products , in particular, drug/device combinations. The current system received a ... the Initiative for Patient Centered Innovation (iPCI) of Fairleigh Dickinson University’s ( ...
Breaking Biology Technology:HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25HealthSouth Reports Results for Second Quarter 2015 26HealthSouth Reports Results for Second Quarter 2015 27HealthSouth Reports Results for Second Quarter 2015 28HealthSouth Reports Results for Second Quarter 2015 29HealthSouth Reports Results for Second Quarter 2015 30HealthSouth Reports Results for Second Quarter 2015 31HealthSouth Reports Results for Second Quarter 2015 32HealthSouth Reports Results for Second Quarter 2015 33HealthSouth Reports Results for Second Quarter 2015 34HealthSouth Reports Results for Second Quarter 2015 35HealthSouth Reports Results for Second Quarter 2015 36
... sets the new global standard to eradicate ... in health care facilities, including MRSA and ... ... BioNeutral announces successful,testing of its Ygiene(TM) Hospital Grade antimicrobial against,antibiotic-resistant microorganisms ...
... Xceed Molecular, a pioneer in,the development of ... has selected the company,s Ziplex,System as a recipient ... Oscars of Invention by The Chicago Tribune, the ... mark of excellence known to industry,government, and academia ...
... SEATTLE and OSLO, Norway, Aug. 19 ... Affitech AS, a,Norwegian human antibody therapeutics company, ... agreement for the discovery and development of ... or mannan-binding,lectin-associated serine protease-2, mediates activation of ...
Cached Biology Technology:BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 2BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 3BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 4Xceed Ziplex(R) System for Automated Gene-Expression Analysis Wins 2008 R&D 100 Award 2Affitech and Omeros Enter Into Antibody Discovery and Development Agreement 2Affitech and Omeros Enter Into Antibody Discovery and Development Agreement 3
... does for enzyme-/substrate-based blotting what intensifying screens do ... up to 10-fold (or one order of magnitude) ... Signal Enhancer membrane treatment is a simple, 15-minute ... current Western blotting protocol. The result is an ...
...
... Expression is a revolutionary new ... analysis. Utilising a novel interface, Expression ... information incredibly simple. Expression uses the ... new standards in the way sequences ...
... Solution is a comprehensive suite of ... specifically designed to reliably extract biological ... genomic studies containing thousands of samples, ... efficient and will analyze large data ...
Biology Products: