Navigation Links
CU-Boulder worm study sheds light on human aging, inherited diseases
Date:10/1/2007

Microscopic worms used for scientific research are living longer despite cellular defects, a discovery that is shedding light on how the human body ages and how doctors could one day limit or reverse genetic mutations that cause inherited diseases, according to a new University of Colorado at Boulder study.

In the first formal study of its kind, researchers manipulated the metabolic state of genetically engineered lab worms called C. elegans and discovered a window of high-efficiency cellular processing that enabled the worms to slow their rate of aging. The findings could one day contribute to the creation of gene therapies to reverse or lessen the effects of mitochondrial diseases, the largest family of human genetic diseases, said lead study author Shane Rea of CU-Boulder's Institute for Behavioral Genetics.

Diseases labeled as mitochondrial are those that affect the mitochondria, the membrane-enclosed power sources present in all cells, Rea said. Researchers believe their insights might find application in treating diseases linked to mitochondrial dysfunction such as Huntington's, Parkinson's and Alzheimer's.

"We appear to have found a window where life is able to preserve itself even better than when operating in the absence of any cellular defects," said Rea. "It's a metabolic state where cells are probably getting close to the best they can be for long life and good health."

Pioneering CU-Boulder worm researcher and Professor Thomas E. Johnson and the University of Rome's Natascia Ventura co-authored the study. Grants from the National Institutes of Health and other agencies funded the research. The findings will appear in the Oct. 2 edition of the Public Library of Science journal PLoS Biology.

Rea, who will continue his research at the University of Texas Health Science Center in San Antonio later this year, said the study validates the worm model for research into the causes of human aging and disea
'/>"/>

Contact: Shane Rea
srea@colorado.edu
303-492-2505
University of Colorado at Boulder
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Morning grogginess more debilitating than sleep deprivation, according to CU-Boulder study
2. Bioartificial kidney under study at MCG
3. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
4. W.M. Keck Foundation funds study of friendly microbes
5. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
6. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
7. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
8. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
9. Study Links Ebola Outbreaks To Animal Carcasses
10. Genome-wide mouse study yields link to human leukemia
11. Breakthrough Microarray-based Technology for the Study of Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... German . ... refraction of X-rays through a specimen instead of attenuation ... are often of much higher quality than those based ... Franz Pfeiffer are particularly interested in developing new approaches ... phase-contrast imaging. One main goal is to make this ...
(Date:7/11/2014)... Social animals often develop relationships with other group members ... In wild chacma baboons the strategy for grooming activities ... are just published in the scientific journal Biology ... of baboons is not practiced without ulterior motives. To ... for the individual, while grooming another individual can provide ...
(Date:7/11/2014)... of mesenchymal stem cells can stimulate neurogenesis in the ... disease (AD) and improve tissue and function injury under ... on the therapeutic effect of adipose-derived stem cells (ADSCs) ... on oxidative injury and neurogenesis in the brain of ... of Life Sciences, Tsinghua University, China transplanted ADSCs into ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2Baboons groom early in the day to get benefits later 2
... BGI, the world,s largest genomic organization, today announced its ... of RNA-Seq in predicting patient outcomes as part of ... U.S. Food and Drug Administration (FDA). The SEQC, also ... MicroArray Quality Control (MAQC), aimed at assessing the technical ...
... upper and lower abdomen is a reliable, minimally invasive way ... indicator of too much male hormone, researchers report. "We ... women that was as non-intrusive and accurate as possible," said ... Sciences University. "We believe this approach is approximately ...
... controlled by the brain from blood pressure to appetite to ... , a team of scientists led by Dr. Gil Levkowitz of ... brain area in which biochemical commands are passed from the brain ... the process, they discovered a surprising new role for the ,hormone ...
Cached Biology News:BGI to play a pivotal role in demonstrating the superior performance of RNA-Seq 2Women's chin, abdomen are good indicators of excessive hair growth 2Women's chin, abdomen are good indicators of excessive hair growth 3A hormone ensures its future 2
(Date:7/10/2014)... study published today in the journal PNAS (Proceedings ... that time of day and sleep deprivation have a ... crucial when looking at the best time of day ... disease, and for administering medicines effectively. , Researchers from ... Research, London, investigated the links between sleep deprivation, body ...
(Date:7/10/2014)... researchers have observed the fractional quantum Hall effect in ... matter can be tuned by an electric field. ... when electrons confined to thin sheets are exposed to ... behavior where thousands of individual electrons behave as a ... effect is well established, many details of this collective ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
(Date:7/10/2014)... at the University of Illinois at Urbana-Champaign provides ... interplay of spin and heat at the nanoscale, ... devices for data storage and information processing. ... spin-angular momentum. In a typical charge current, electrons, ... current," explained David Cahill, a professor of materials ...
Breaking Biology Technology:Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2
... ADVENTRX Pharmaceuticals,Inc. (Amex: ANX ) a biopharmaceutical ... candidates for the treatment,of cancer and infectious diseases, ... officer, is scheduled to present at the 2007,Thomas ... at 1:30 p.m. Eastern Daylight Time. The conference ...
... PXS, Nasdaq: PXSL) today announced that its Phase ... people with bronchiectasis has met its two,primary efficacy ... Data from the 362 subject study demonstrated a ... weeks of treatment with Bronchitol,as assessed by the ...
... SOMERSET, N.J., Aug. 28 DOV Pharmaceutical,Inc. ("DOV" or ... today that its common stock is now being quoted ... common stock is also still,being quoted on the Pink ... common stock are now being quoted,both on the OTC ...
Cached Biology Technology:ADVENTRX Pharmaceuticals to Present at the 2007 Thomas Weisel Partners Healthcare Conference 2Phase III Trial Finds Pharmaxis' Bronchitol Effective 2Phase III Trial Finds Pharmaxis' Bronchitol Effective 3DOV Pharmaceutical, Inc. Begins Trading on OTC Bulletin Board 2
...
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z35,347-7) or contact ...
... Freedom EVO96R and Freedom EVO384R are ... instrument, available in three different sizes, with ... arm. They deliver significant time saving, with ... an easy setup of your assays with ...
... and Freedom EVO384R are fast multi-channel pipetting ... three different sizes, with a multi-channel head ... significant time saving, with true parallel processing ... of your assays with the Freedom EVOware ...
Biology Products: