Navigation Links
CU-Boulder stem cell research may point to new ways of mitigating muscle loss
Date:2/16/2014

New findings on why skeletal muscle stem cells stop dividing and renewing muscle mass during aging points up a unique therapeutic opportunity for managing muscle-wasting conditions in humans, says a new University of Colorado Boulder study.

According to CU-Boulder Professor Bradley Olwin, the loss of skeletal muscle mass and function as we age can lead to sarcopenia, a debilitating muscle-wasting condition that generally hits the elderly hardest. The new study indicates that altering two particular cell-signaling pathways independently in aged mice enhances muscle stem cell renewal and improves muscle regeneration.

One cell-signaling pathway the team identified, known as p38 MAPK, appears to be a major player in making or breaking the skeletal muscle stem cell, or satellite cell, renewal process in adult mice, said Olwin of the molecular, cellular and developmental biology department. Hyperactivation of the p38 MAPK cell-signaling pathway inhibits the renewal of muscle stem cells in aged mice, perhaps because of cellular stress and inflammatory responses acquired during the aging process.

The researchers knew that obliterating the p38 MAPK pathway in the stem cells of adult mice would block the renewal of satellite cells, said Olwin. But when the team only partially shut down the activity in the cell-signaling pathway by using a specific chemical inhibitor, the adult satellite cells showed significant renewal, he said. "We showed that the level of signaling from this cellular pathway is very important to the renewal of the satellite cells in adult mice, which was a very big surprise," said Olwin.

A paper on the subject appeared online Feb. 16 in the journal Nature Medicine.

One reason the CU-Boulder study is important is that the results could lead to the use of low-dose inhibitors, perhaps anti-inflammatory compounds, to calm the activity in the p38 MAPK cell-signaling pathway in human muscle stem cells, said Olwin.

The CU-Boulder research team also identified a second cell-signaling pathway affecting skeletal muscle renewal a receptor known as the fibroblast growth factor receptor-1, or FGFR-1. The researchers showed when the FGFR-1 receptor protein was turned on in specially bred lab mice, the renewal of satellite cells increased significantly. "We still don't understand how that particular mechanism works," he said.

Another major finding of the study was that while satellite cells transplanted from young mice to other young mice showed significant renewal for up to two years, those transplanted from old mice to young mice failed. "We found definitively that satellite cells from an aged mouse are not able to maintain the ability to replenish themselves," Olwin said. "This is likely one of the contributors to loss of muscle mass during the aging process of humans."

Co-authors included first author and CU-Boulder postdoctoral researcher Jennifer Bernet, former CU-Boulder graduate student John K. Hall, CU-Boulder undergraduate Thomas Carter, and CU-Boulder postdoctoral researchers Jason Doles and Kathleen Kelly-Tanaka. The National Institutes of Health and the Ellison Medical Foundation funded the study.

Olwin said skeletal muscle function and mass decline with age in humans beginning at roughly age 40. While there are a variety of muscle-wasting diseases -- ranging from muscular dystrophy to Lou Gehrig's disease -- the condition known as sarcopenia can lead to severe muscle loss, frailty and eventual death and is leading to skyrocketing health care costs for the elderly. "If you live long enough, you'll get it," he said.

Olwin and his team worked closely on the research with a team from Stanford University led by Professor Helen Blau, which published a companion paper in the same issue of Nature Medicine. "We shared data with the Stanford team during the entire process and we all were very pleased with the study outcomes," said Olwin. "This is how science should work."


'/>"/>

Contact: Bradley Olwin
bradley.olwin@colorado.edu
303-492-6816
University of Colorado at Boulder
Source:Eurekalert

Related biology news :

1. CU-Boulder researchers sequence worlds first butterfly bacteria, find surprises
2. New CU-Boulder study shows differences in mammal responses to climate change
3. Slippery bark protects trees from pine beetle attack, according to CU-Boulder study
4. CU-Boulder to fly antibiotic experiment, education project on ants to space station
5. CU-Boulder-led team finds first evidence of primates regularly sleeping in caves
6. Connections in the brains of young children strengthen during sleep, CU-Boulder study finds
7. Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
8. CU-Boulder-led team gets first look at diverse life below rare tallgrass prairies
9. Poorly camouflaged insects can kick off a cascade of ecological impacts, new CU-Boulder study finds
10. New CU-Boulder-led study finds microbial clock may help determine time of death
11. CU-Boulder helps tap crowds to digitize museum records of bugs and plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... March 2, 2017 Summary This report ... and its partnering interests and activities since 2010. ... Read the full ... Alliance since 2010 report provides an in-depth insight into the ... companies. On demand company reports are prepared upon ...
(Date:3/2/2017)... 2017 Australian stem cell and regenerative medicine ... signed an agreement with the Monash Lung Biology Network, ... Institute and Department of Pharmacology at Monash University, ... study to support the use of Cymerus™ mesenchymal stem ... Asthma is a chronic, long term lung condition ...
(Date:2/28/2017)... , February 28, 2017 News solutions for ... ... from 14 to 16 March, Materna will present ... show how seamless travel is a real benefit for passengers. ... biometrics to their passenger touch point solutions to take passengers through ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... According to a report by Transparency Market ... due to the presence of a large pool of participants; however, ... , and Sigma-Aldrich, compete with each other in this market. With ... than 76% of this market in 2016.  ... As of now, a large number of ...
(Date:3/23/2017)... 2017 In today,s pre-market research, ... the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate ... SYN), and Regulus Therapeutics Inc. (NASDAQ: RGLS ... Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn ... at: ...
(Date:3/22/2017)... 22, 2017 Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), today ... (RGC), U.K. Biobank and GSK to generate genetic sequence data ... The initiative will enable researchers to gain valuable insights to ... wide range of serious and life threatening diseases. ... Genetic evidence ...
(Date:3/22/2017)... , March 22, 2017  Ascendis Pharma A/S ... innovative TransCon technology to address significant unmet medical ... for the full year ended December 31, 2016. ... for our company as we broadened our pipeline ... integrated rare disease company with an initial focus ...
Breaking Biology Technology: