Navigation Links
CU-Boulder researchers uncover new target for cancer research
Date:10/25/2012

In a new paper released today in Nature, BioFrontiers Institute scientists at the University of Colorado Boulder, Tom Cech and Leslie Leinwand, detailed a new target for anti-cancer drug development that is sitting at the ends of our DNA.

Researchers in the two scientists' laboratories collaborated to find a patch of amino acids that, if blocked by a drug docked onto the chromosome end at this location, may prevent cancerous cells from reproducing. The amino acids at this site are called the "TEL patch" and once modified, the end of the chromosome is unable to recruit the telomerase enzyme, which is necessary for growth of many cancerous cells.

"This is an exciting scientific discovery that gives us a new way of looking at the problem of cancer," Cech said. "What is amazing is that changing a single amino acid in the TEL patch stops the growth of telomeres. We are a long way from a drug solution for cancer, but this discovery gives us a different, and hopefully more effective, target."

Cech is the director of the BioFrontiers Institute, a Howard Hughes Medical Investigator and winner of the 1989 Nobel Prize in chemistry.

Co-authors on the study include postdoctoral fellows Jayakrishnan Nandakumar and Ina Weidenfeld; University of Colorado undergraduate student Caitlin Bell; and Howard Hughes Medical Institute Senior Scientist Arthur Zaug.

Telomeres have been studied since the 1970s for their role in cancer. They are constructed of repetitive nucleotide sequences that sit at the ends of our chromosomes like the ribbon tails on a bow. This extra material protects the ends of the chromosomes from deteriorating, or fusing with neighboring chromosome ends. Telomeres are consumed during cell division and, over time, will become shorter and provide less cover for the chromosomes they are protecting. An enzyme called telomerase replenishes telomeres throughout their lifecycles.

Telomerase is the enzyme tha
'/>"/>

Contact: Emilia Costales
emilia.costales@colorado.edu
303-735-3001
University of Colorado at Boulder
Source:Eurekalert

Page: 1 2

Related biology news :

1. CU-Boulder-led team finds microbes in extreme environment on South American volcanoes
2. Nitrogen pollution changing Rocky Mountain National Park vegetation, says CU-Boulder-led study
3. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
4. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
5. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
6. UNH researchers find African farmers need better climate change data to improve farming practices
7. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
8. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
9. Researchers print live cells with a standard inkjet printer
10. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
11. Researchers reveal how a single gene mutation leads to uncontrolled obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Sept. 30, 2014  Spectra Automation, a ... the biotech and power generation industries, announced ... Bioprocess Manager, an easy-to-use and cost-effective data ... bioprocess development laboratories. Most ... and analyzer systems. Accessing and consolidating data ...
(Date:9/29/2014)... study confirms that the exposure to tar tended to ... regular cigarettes. Similarly, exposure to nicotine tended to ... type of cigarette in several countries around the world. ... toxic chemicals in the smoke of these cigarettes are ... levels of chemicals in the smoke are not necessarily ...
(Date:9/29/2014)... Parents with children at home should use ventilation when ... University are recommending, after a new study showed an ... symptoms and chronic bronchitis. , "In homes where a ... asthma and wheezing is higher than in homes where ... Smit, an associate professor in the College of Public ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... CLEVELAND, Ohio - Cleveland Botanical Garden and Kent State ... pioneering scientific center for research in the field - ... research greenhouses on the Gardens campus. By ... the partnership could, in effect, control sunlight, extending the ...
... Pixelplus Co.,Ltd. (Nasdaq: PXPL ), ... designs,develops, and markets CMOS image sensors for ... unveiled the "PM1002", the Company,s,new ,System-On-A-Chip, ("SoC") ... PM1002 integrates a 32-bit RISC microprocessor and ...
... intricate transfer of information from a segment of DNA ... stationed in special "transcription factories" within a cell nucleus, ... II (Pol II) and other key molecules can assemble ... the gene,s position., The findings, published in the Dec. ...
Cached Biology News:Research project aims to control sunlight, extend growing season and conserve energy 2Pixelplus Unveils Its PM1002 as A Practical Biometric Solution for Iris, Facial and Fingerprint Recognition 2Pixelplus Unveils Its PM1002 as A Practical Biometric Solution for Iris, Facial and Fingerprint Recognition 3Research sheds light on the mechanics of gene transcription 2
(Date:10/1/2014)... , Oct. 1, 2014 Pfanstiehl has ... (USP/NF, EP), manufactured in the USA ... has long been recognized for playing a key ... growing body of evidence that media supplementation with ... of protein glycosylation," according to Dr. Christopher ...
(Date:10/1/2014)... Washington, USA (PRWEB) September 30, 2014 ... yet efficient arrangements that have evolved in nature over ... biomimetic and bioinspired materials for applications in biophotonics ... Biomedical Optics . The journal is published by SPIE, ... SPIE Digital Library. Several of the peer-reviewed articles are ...
(Date:10/1/2014)... Sept. 30, 2014 This report ... in US$ Million by the following Product ... Enzymes. Specific end-use segments also analyzed are ... The report provides separate comprehensive analytics ... Middle East, and Latin America. Annual estimates ...
(Date:9/30/2014)... of one of nature,s most efficient light-harvesting structures, ... by Alejandro Briseno of the University of Massachusetts ... long-sought polymer architecture to boost power-conversion efficiency of ... , Briseno, with colleagues and graduate students ... and Dresden University of Technology, Germany, report in ...
Breaking Biology Technology:Pfanstiehl Launches cGMP-produced Mannose for Cell Culture Media Optimization & Glycoprotein Biosynthesis 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3
... of its Board of Directors, held today, Wyeth (NYSE: ... of the Company.A dividend of thirty cents ($.30) per share on ... 1, 2009 to stockholders of record at the close of business ... cents ($.50) per share on the outstanding shares of Preferred Stock ...
... William White, Continental Airlines CEO Larry Kellner, and the ... CAMBRIDGE, Mass., April 23 TechConnect World today announced ... the TechConnect World trio of conferences -- ... TechConnect Summit events, at the George R. Brown Convention ...
... SQNM ), today announced that it will report first ... 2009. The company will conduct a conference call and an ... on the same day., Conference Call Information:, ... callers: 1 (706) 679-9912, , , Webcast information: ...
Cached Biology Technology:TechConnect World Conference Showcases Houston Leaders May 3-7, at the George R. Brown Convention Center 2TechConnect World Conference Showcases Houston Leaders May 3-7, at the George R. Brown Convention Center 3SEQUENOM to Hold First Quarter 2009 Financial Results Conference Call on April 30 2
Rabbit polyclonal to MDM2 (phospho S185) ( Abpromise for all tested applications). entrezGeneID: 4193 SwissProtID: Q00987...
ASCIZ...
...
Yields DNA greater than 50 kb in length from yeast, fungi, Gram neg. and Gram pos. bacteria...
Biology Products: