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CSHL team traces extensive networks regulating alternative RNA splicing
Date:9/19/2008

d RNA targets play important roles in neuromuscular functions and disorders." That is a direct reflection of the fact, also demonstrated in the experiments, that Fox-1 and Fox-2 are either exclusively or preferentially expressed in brain, heart, and skeletal muscle. This is consistent with prior studies showing that some people with genetic diseases including epilepsy, mental retardation and autism, have mutations of the Fox-1 gene or abnormally express it.

"The Fox-1 and -2 proteins are essential regulators of specific splicing events that occur in cells of particular tissues," Krainer said. "Our ability to trace their regulatory networks and observe how they are conserved, albeit with significant variation, across and within species, may lead to potential approaches for intervention in cases where, because of genetic mutation, vital cellular functions are perturbed. One key to this is our ability to place discrete disease-associated genes into well-defined gene-regulatory networks. We anticipate that our continuing work will shed new light on such networks."


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Contact: Peter Tarr
tarr123@gmail.com
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

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