Navigation Links
CSHL team traces extensive networks regulating alternative RNA splicing
Date:9/19/2008

lative size of other genomes that surprised scientists.

The common fruit fly that hovers over your ripening bananas, for instance, possesses some 14,000 genes. It's perfectly obvious that human beings are vastly more complex, biologically, than a fly. Molecular biologists have demonstrated in recent years that it is not the number of genes that is the key to complexity but rather the number and diversity of gene products that a given set of genes can instruct cells to manufacture.

Rather than a single gene ordering the production of a single kind of protein, as scientists used to assume, it turns out that individual genes can in some cases give rise to dozens or even thousands of different proteins, thanks to a phenomenon called alternative splicing.

Zhang and Krainer's new research focused on splicing, which is the "editing" of RNA molecules generated by activated genes. By cutting up and pasting back together bits of these RNA intermediaries, the splicing machinery deletes "non-coding" segments (called introns) and stitches together "coding" segments (called exons).

The final product of RNA splicing (called a mature messenger-RNA "transcript") finds its way out of the cell nucleus. Carrying the "message" of an activated gene, it enters a structure called the ribosome, which reads its coding instructions and manufactures a protein with a particular configuration. The protein's shape--and function--will vary depending on how the splicing factors back in the nucleus have cut and pasted together the final RNA transcript which has served as the blueprint for the protein's manufacture.

How are splicing-factor targets recognized?

The question addressed by Zhang and Krainer is how particular splicing factors can recognize their specific targets. How do these proteins know where to attach to raw, "unedited" RNA transcripts, and how do they engage the cellular machinery that actually splices RNAs--a compl
'/>"/>

Contact: Peter Tarr
tarr123@gmail.com
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Computer program traces ancestry using anonymous DNA samples
2. Technique traces origins of disease genes in mixed human populations
3. UC biology prof traces his roots to the first Earth Day
4. Glowing films developed by UC San Diego chemists reveal traces of explosives
5. BASF and Harvard University announce extensive research collaboration
6. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
7. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
8. Alternative food networks connect ethical producers and consumers and can lead to healthier eating
9. Solidus Networks, Inc. Seats New Board of Directors
10. Gene Networks in Animal Development and Evolution Feb. 15 and 16
11. Nature paper describes technique for extracting hierarchical structure of networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Philadelphia, PA, July 10, 2014 Inflammatory diseases ... same patient, complicating treatment because a medication effective ... such example is the anti-arthritic medication dexamethasone, which ... disease. A study in the August issue of ... the effects of a new class of anti-arthritic ...
(Date:7/9/2014)... out one gene for another in a line of ... to reality within this decade. As with any new ... fixing disease-causing genes in humans, for example--as well as ... one of those concerns to rest: using gene-editing techniques ... mutations in the cells. The new results were published ...
(Date:7/9/2014)... Sexual selection refers to species, selection for traits ... type of natural selection enhances opportunities to mate, the ... Biologists at the University of California, Riverside have now ... of a placenta are linked. Describing the life ... the family Poeciliidae, the researchers found that species with ...
Breaking Biology News(10 mins):New class of anti-arthritis drugs effectively treats multiple inflammatory diseases 2No extra mutations in modified stem cells, study finds 2No extra mutations in modified stem cells, study finds 3Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4
... data to a Phase 2 trial conducted by the ... an 89% survival rate in mantle cell lymphoma patients. ... Historically, patients with this type of lymphoma only have ... 20% chance of surviving 5 years. BiovaxID, an investigational ...
... Florida scientists have found that people have an ancient ... by a jawless, eel-like fish. , It turns out ... road than almost all other backboned animals, may not ... the genetics that govern their skeletal development, according to ...
... in humans are genetically based. The influence of ... of humans are complicated by a multitude of cultural ... Alcoholism: Clinical & Experimental Research use rhesus ... consumption. Results indicate that, just as with humans, ...
Cached Biology News:BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins 2UF scientists reveal ancient origin of vertebrate skeleton 2UF scientists reveal ancient origin of vertebrate skeleton 3Genetic and environmental influences on alcohol consumption among rhesus monkeys 2
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
(Date:1/14/2014)... 14, 2014 As pet owners drew up their lists of ... wrote: "Take better care of my furry companion." Nowadays there are ... top-brand carrying cases to take the little canine or feline darlings ... compelled to buy some pricey toys at the pet store. But ...
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
(Date:1/14/2014)... Kinaxis ®, provider of RapidResponse ®, a cloud-based supply ... ( S&OP ) service, is proud to be a gold ... held at the Hilton San Diego Bayfront, January 30 – ... Kaszas , Director of Supply Chain at Amgen, as she ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... There may no yellow tape or chalk outlines of a ... if they want remedies, said a lawyer who spoke at ... ,Daniel Vaccaro, a partner with Michael Best & Friedrich ... Internet fraudsters or disgruntled employees can benefit from learning to ...
... — Craig Schiefelbein has a warning for chief information officers: ... made by lower-level business executives. The CEO of Paragon ... will have to work to stay involved with the business ... , ,"That's a big change in a really short period ...
... of chief information officers for their number-one issue, they ... ,Today, the consensus issue is compliance, particularly with the ... of the Sarbanes-Oxley Act of 2002, or SOX, as ... passed largely in reaction to the corporate scandals that ...
Cached Biology Technology:After a successful attack on your computer systems, then what? 2After a successful attack on your computer systems, then what? 3IT outsourcing remains on the horizon as companies focus on core business 2IT outsourcing remains on the horizon as companies focus on core business 3With Sarbanes-Oxley, compliance takes center stage for CIOs 2With Sarbanes-Oxley, compliance takes center stage for CIOs 3
... The mycobacteria in Complete Freund's adjuvant attract ... site which enhances the immuneresponse. For this ... for the initial injections; Incomplete Freund's adjuvant ... (preferably in saline) are typically mixed with ...
The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma....
2,4-Dinitrophenyl hapten is conjugated to Keyhole Limpet (KLH) protein through lysine....
Alexa Fluor 350/488/594 Filter Set (Semrock Brightline) *mounted* *Zeiss Axio AF...
Biology Products: