Navigation Links
CSHL team solves a protein complex's molecular structure to explain its role in gene silencing
Date:11/13/2011

ua-Tor. For the last few years, her team has explored these questions in fission yeast.

In the current study, the combined use of X-ray crystallography and biochemisty by Research Investigator Thomas Schalch, Ph.D., has yielded a much better picture and revealed further details of how Chp1 interacts with the Tas3 protein. These experiments have also identified a previously unknown substructure at the very end of Chp1.

A clue about what role this structure, called the PIN domain, might play in heterochromatin assembly came from scouring a protein database. The team found that other proteins that had similar structural features were associated with telomeres, the cap-like structures at the end of chromosomes. In fission yeast, telomeres are one of the locations where heterochromatin is found, another being the centromere -- the dense knob-like structure at the center of a chromosome.

The team found that deleting the PIN domain from Chp1 prevented heterochromatin formation at the telomeres but didn't affect formation at the centromere. "This suggests different functions of RITS proteins at centromeres vs telomeres," says Joshua-Tor. "RITS might be exerting its effect at centromeres through Ago1 and the RNAi machinery, but might enforcing its function at the telomeres through Chp1 and its PIN domain." The team is now turning its focus to understanding how these various functions are regulated.


'/>"/>
Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Genetic sleuth solves glaucoma mystery
3. Brown biologist solves mystery of tropical grasses origin
4. A collaboration solves the herpes virus protein structure providing new drug therapy directions
5. Mystery dissolves with calcium pump discovery
6. Of mice and men: UNC-led team solves mouse genome dilemma
7. Team solves decades-old molecular mystery linked to blood clotting
8. DNA solves identities of Australian melons and loofah
9. Robot biologist solves complex problem from scratch
10. Photonic crystal biosensors detect protein-DNA interactions
11. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/24/2015)... 24, 2015   Crossmatch ™, a leading ... that its U.are.U ® 4500 Fingerprint Readers ... Bros . to achieve PCI compliance for Point-of-Sale ... to the POS terminal, protecting the retailer and ... breaches. With one-third of worldwide ...
(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... of Southern California have taken an important first ... therapy. Huntington Disease is an incurable neurological ... loss of intellectual faculties. It affects about 30,000 ... parents with the disease have a 50 percent ...
... posted a status update on the social networking Web ... Just 23 characters long, his message, "using EEG to ... "locked-in" patients can couple brain-computer interface technologies with modern ... doctoral student, Wilson is among a growing group of ...
... Mair of Virginia Beach, a graduate student in ... the first-ever Rachel Carson Award for Scientific Excellence ... is a biologist at the agency,s White Sulphur ... service employees who demonstrate superior scientific involvement and ...
Cached Biology News:New hope for treatment of neurodegenerative disorder 2New hope for treatment of neurodegenerative disorder 3Researchers use brain interface to post to Twitter 2Researchers use brain interface to post to Twitter 3
(Date:5/5/2015)... , May 5, 2015 ImmunoCellular ... Andrew Gengos , President and Chief Executive ... 7, 2015. DATE:  Thursday, May 7, 2015     ... http://VirtualInvestorConferences.com > click the red "register/ ... a live, interactive online event where investors are ...
(Date:5/5/2015)... and WASHINGTON, D.C., USA (PRWEB) May 05, 2015 ... U.S. export regulations covering a wide range of key ... say are hampering global competitiveness of U.S. industry. To ... a webinar on 12 May on the ... which governs the commodities covered by International Traffic in ...
(Date:5/5/2015)... 05, 2015 Research and Markets ... the "Clinical Laboratory, Molecular Diagnostics and Genomic ... 2019 - Global Version" report to their ... the area of molecular diagnostics and pharmacogenics hold ... world market that is moving out of the ...
(Date:5/5/2015)... , May 5, 2015 CytomX, a biotechnology ... today announced that Sean McCarthy , D. Phil., ... Antibody Day in New York ... McCarthy will present an overview of CytomX,s Probody pipeline, ... conjugate programs. About CytomX Therapeutics CytomX ...
Breaking Biology Technology:ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2
... FRANCISCO, March 7, 2012  More than 1,100 leaders from ... Francisco for the two-day conference CALBIO2012: Driven by Patients ... patient access to new treatments through partnering and collaborative ... BIOCOM are organizing a statewide meeting for California,s life ...
... Palatin Technologies, Inc. (NYSE Amex: PTN ) ... ROTH OC Growth Stock Conference on Tuesday, March 13, 2012, ... at the Ritz Carlton Laguna Niguel in Dana Point, CA. ... Officer of Palatin Technologies, will provide an update on Palatin,s ...
...  Synthetic Biologics, Inc.  (NYSE Amex: SYN ), ... medicines for serious illnesses, announced today that Jeff Riley, ... ROTH Capital Partners 24th Annual Growth Stock Conference. The ... Ritz Carlton in Dana Point, CA. Mr. Riley will ...
Cached Biology Technology:First Statewide Biotech Meeting Focuses on Patient Access, Innovation 2Synthetic Biologics to Present at ROTH Annual Growth Stock Conference 2
... of BAC (100+kb), fosmid (40kb), and large ... than any othe BAC vector. On command ... and easy recombinant DNA purification. Available with ... VC) vectors for the highest insert stability. ...
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
MAGP-2 (C-19)...
Laminin gamma-2 (G-16)...
Biology Products: