Navigation Links
CSHL team shows how loss of key protein promotes aggressive form of leukemia
Date:7/1/2010

f-renewing. But the team observed that cells with oncogenic Kras combined with a p53 deficiency did acquire the capacity to indefinitely self-renew, and transform into leukemia-initiating cells.

"Mice with one or the other mutation do develop T-cell malignancies, albeit ones with long latencies," Zhao says. "But we showed how suppression of p53 cooperates with oncogenic Kras to promote AML of the treatment-resistant type. Importantly, we found that loss of p53, independently of oncogenic Kras activation, promotes the proliferation of myeloid progenitors." It is the combination of p53 loss and activation of oncogenic Kras that confers upon these cells the ability to continually self-renew and thus give rise to aggressive AML.

"In this work, we discovered a new tumor-suppressing function of p53, distinct, for instance, from apoptosis, and somewhat related to senescence," said Zuber. "We showed that it has the ability to reinforce cell-fate and differentiation programs. In AML, p53 loss leads to cancer by disabling this reinforcement. The question we are now eager to answer is whether p53 has similar functions in other types of cancer."


'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Flowering and freezing tolerance linked in wheat, study shows
2. Apples grow larger when cells dont divide, study shows
3. Study shows stability and utility of floating wind turbines
4. Same types of cell respond differently to stimulus, Stanford study shows
5. Soil-borne pathogens drive tree diversity in forests, study shows
6. Study shows adding UV light helps form Missing G of RNA building blocks
7. Suspended animation protects against lethal hypothermia, study shows
8. New online map shows network of protection for North Americas marine ecosystems
9. New psychological intervention program shows promise in helping those with bowel diseases
10. Stem-cell disruption induces skull deformity, UR study shows
11. Ultraviolet radiation not culprit killing amphibians, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... your doctor to know what goes wrong with your muscles ... to know what "normal" actually is. That,s where a new ... FASEB Journal comes in. In the ... set of molecules that can help scientists "see" which genes ... more, they found never-before-detected gene activity and that men have ...
(Date:9/30/2014)... ARLINGTON HEIGHTS, Ill. (September 30, 2014) People who ... they can do to control their asthma besides properly ... to a new article in the Annals of ... the American College of Allergy, Asthma and Immunology (ACAAI), ... by examining their lifestyle. The woman described in the ...
(Date:9/29/2014)... DC Monday, September 29: Between 1970 and ... fish around the globe dropped 52 percent, says ... World Wildlife Fund (WWF). This biodiversity loss occurs ... resource use of high-income countries. , In addition ... report,s data point to other warning signs about ...
Breaking Biology News(10 mins):Scientists identify which genes are active in muscles of men and women 2Asthma symptoms kicking up? Check your exposure to air pollution 2Half of global wildlife lost, says new WWF report 2
... part of the Genome Canada Large-Scale Applied Research Project ... to 16 projects across the country, the researchers in ... with the aim of identifying genes or proteins for ... target cancers and other diseases. The first project, ...
... - New research from the University of Calgary,s Faculty ... diagnosis using an iPhone application with the same accuracy ... technology can be particularly useful in rural medical settings. ... neurologists, regardless of where the physicians and patients are ...
... has revealed how infection by a parasitic fungus dramatically changes ... leonardi ), causing them to become zombie-like and to die ... fungus. The multinational research team studied ants living high up ... research will be published in the BioMed Central open-access journal ...
Cached Biology News:OGI genomics researchers awarded $23 million 2OGI genomics researchers awarded $23 million 3iPhone can diagnose stroke: study 2Zombie ants have fungus on the brain, new research reveals 2
(Date:9/30/2014)... Report Details Biosimilar drugs – ... Do you want to find sales potentials of ... for those biological drugs from 2014, helping you ... data, R&D trends, opportunities and selling prospects. In ... 2024 at overall world market, therapeutic class, molecule ...
(Date:9/30/2014)... September 30, 2014 Proove Biosciences ... is excited to announce a new genetic test built ... Proove Pain Perception Test will provide physicians with ... why pain tolerance levels are stratified between individuals. With ... whether a person has a genetic predisposition that will ...
(Date:9/30/2014)... BUDAPEST, Hungary , September 30, 2014 /PRNewswire/ ... libraries and intuitive browsing of chemistry in documents ... providing chemistry software solutions and consulting services for ... extract chemical information and generate Markush structures from ... securing an organizations intellectual property, however generating and ...
(Date:9/30/2014)... and ROCKVILLE, Md., Sept. 30, 2014 ... focusing on commercializing market-relevant biohealth innovations and increasing access ... , announced today that venture capitalist, Tania Fernandez ... strategic advisor. Dr. Fernandez will be a member of ... which will provide up to $50 million in seed ...
Breaking Biology Technology:Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2
... 11, 2011 Novavax, Inc. (Nasdaq: NVAX ... by the Tech Council of Maryland (TCM), the largest ... communities of Maryland.  Novavax was recognized as the firm ... community and for its presence and leadership in Maryland. ...
... May 11, 2011 Verenium Corporation (Nasdaq: ... the development and commercialization of high-performance enzymes, ... will present at two upcoming conferences. Mr. ... Solutions Conference as part of the "Biofuels" panel discussion ...
... Ill., May 11, 2011 Naurex Inc., a clinical-stage ... psychiatry and neurology, today announced the completion of an ... Partners and Latterell Venture Partners.  Druid BioVentures, Genesys Capital, ... in the round.  Naurex will use the proceeds from ...
Cached Biology Technology:Novavax Named Biotechnology Firm of the Year by Tech Council of Maryland 2Verenium to Present at Upcoming Conferences 2Verenium to Present at Upcoming Conferences 3Naurex Completes $18 Million Series A Financing 2Naurex Completes $18 Million Series A Financing 3Naurex Completes $18 Million Series A Financing 4Naurex Completes $18 Million Series A Financing 5Naurex Completes $18 Million Series A Financing 6Naurex Completes $18 Million Series A Financing 7
... electrophoresis into an automated, high-throughput operation with ... system is ideal for analyzing multiple PCR ... Fully automated, robot-compatible, and ready to put ... your high-throughput screening assignments as easy as ...
...
Fluorescence Preserving Media, 100 mL...
Size & Applications: 20 ml Storage Temp.: -20C Shelf Life: 12 months ...
Biology Products: