Navigation Links
CSHL team shows how loss of key protein promotes aggressive form of leukemia
Date:7/1/2010

st and embryonic stem cells.

Graduate student Zhen Zhao, postdoctoral researcher Johannes Zuber, M.D., along with Lowe and others, hypothesized that loss of the p53 protein could impair the programmed cell fate and mortality of myeloid progenitors. "Although myeloid progenitors and their differentiated progeny normally lack self-renewal capabilities," explains Zhao, "these cells apparently acquire this ability during the course of leukemia development. How this happens is what we set out to discover."

Zhao and colleagues knew that mutations in Kras and other genes in the Ras signaling pathway can trigger replication stress in immature blood cells, in some instances calling p53 into action. That protein possesses a range of biological activities that are thought to contribute to its role in tumor suppression, including the ability to induce a cell to commit suicide (apoptosis) or to enter a quiescent state in which it can no longer multiply (senescence). When the p53 protein is missing or inactive, for instance due to a mutation in the gene that encodes it, a potentially vital element in a cell's "braking" system is disabled. Indeed, "mutational disruption of the p53 network is thought to occur in virtually all aggressive end-stage cancers," notes Zhao, although mutations are seen in only 10%-15% of AML cases at diagnosis. Those tend to be the cases most resistant to therapy and most likely to be lethal.

Using so-called mosaic mouse models, the Lowe lab recently demonstrated that p53 mutations could specifically confer resistance to chemotherapeutic agents used to treat AML in human patients. Zhao, Zuber and colleagues took advantage of these genetically hybrid mice and a technology called RNA interference, or RNAi. Using a short-hairpin RNA molecule, they inactivated the p53 gene in hematopoietic cells that also had mutations that made Kras oncogenic. Myeloid precursor cells with only the Kras mutation are proliferative, but not sel
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Flowering and freezing tolerance linked in wheat, study shows
2. Apples grow larger when cells dont divide, study shows
3. Study shows stability and utility of floating wind turbines
4. Same types of cell respond differently to stimulus, Stanford study shows
5. Soil-borne pathogens drive tree diversity in forests, study shows
6. Study shows adding UV light helps form Missing G of RNA building blocks
7. Suspended animation protects against lethal hypothermia, study shows
8. New online map shows network of protection for North Americas marine ecosystems
9. New psychological intervention program shows promise in helping those with bowel diseases
10. Stem-cell disruption induces skull deformity, UR study shows
11. Ultraviolet radiation not culprit killing amphibians, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... 2015 Fingerprint Cards (FPC) has ... from the distributor World Peace Industrial Group (WPI), part ... although the major part of the shipments will take ... by smartphone manufacturers in China . ... the communicated revenue guidance of + 1 000 MSEK for ...
(Date:3/31/2015)... NEW YORK , March 31, 2015   ... announced the launch of the Post-Surgical Pain Management TRACKER, ... data products tracking usage trends in the medical device ... monthly access to data including treatment volumes, market share, ... manage the pain associated with joint surgery. ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition ... Report" report to their offering. This report analyzes ... by the following Segments: Face Biometrics, and Voice Biometrics. The report ... , Japan , Europe , ... & Africa , and Latin America ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... molecule which can stop the formation of long protein ... in kidney dialysis patients has been identified by researchers ... lead to new methods to identify drugs to prevent, ... which amyloid fibrils play a part, including Alzheimer,s, Parkinson,s ...
... scientists have long debated whether all cells within a tumour ... - a question that has been highly investigated in experimental ... Nature Medicine (10.1038/nm.2415) focuses on patients and shows that ... properties, called leukemia stem cells (LSC), that are better at ...
... The role of national governments in ecological ... While scientists and campaigners alike often demand that ... and conflicts with land owners or corporations makes ... Ecology reports, Brazil is one of a handful ...
Cached Biology News:Research offers new way to target shape-shifting proteins 2New research validates clinical importance of leukemia stem cells 2
(Date:4/27/2015)... 2015  MT Services LLC, a Lawsuit Settlement ... that U.S. District Judge Joseph Goodwin ... status meeting in hopes to resolve more than ... manufacturers who are involved in multidistrict litigations under ... going on for some time, and Judge Goodwin ...
(Date:4/27/2015)... -- Together with its customers, Elekta raised EUR 30,575 (USD ... Barcelona . The funds will be donated to ... improve cancer care, specifically radiation oncology care, around the ... should be denied potentially life-saving treatment simply because the ... and clinics around the world to take care of ...
(Date:4/24/2015)... April 24, 2015 Top student social ... San Diego area universities, including UCSD and SDSU, will ... from prominent local, national and nonprofit companies for an ... 5th Annual Social Innovation Challenge 2015 . , ... social venture ideas addressing a diverse range of issues ...
(Date:4/24/2015)... DryLet, LLC a biotechnology company ... as animal waste reduction, bioremediation, wastewater treatment, aquaculture ... treatment plants and restaurant kitchen settings, announced today ... Restaurant Association’s NRA Show 2015, in Chicago, Illinois ... company will be available to share information about ...
Breaking Biology Technology:Transvaginal Mesh Lawsuit News: Another Joint Conference Status Meeting Ordered by Judge to Resolve More than 70K TVM Lawsuits against Several Mesh Manufacturers, Says Lawsuitsettlementnews.com 2Transvaginal Mesh Lawsuit News: Another Joint Conference Status Meeting Ordered by Judge to Resolve More than 70K TVM Lawsuits against Several Mesh Manufacturers, Says Lawsuitsettlementnews.com 3Elekta helps raise $33,000 to bring radiation treatment to developing countries 2Elekta helps raise $33,000 to bring radiation treatment to developing countries 35th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 3DryLet to Showcase Bio-React at the National Restaurant Association’s NRA Show 2015 May 16-19, 2015 in Chicago, Illinois 2
... , ... SmithKline Beecham Pharmaceuticals, UK , ... is a 96-well white polystyrene microplate with scintillant-coated wells designed for highvolume, ... platform for the measurement of G-protein activation by means of an assay ...
... INTRODUCTION , ... upon binding of an agonist, a transient increase in intracellular ... and is an important modulator of many physiological mechanisms (reviewed ... (1997)). Measurement of intracellular calcium concentration in cells expressing a ...
... Author: , Heidi Grecsek ... 710 Bridgeport Avenue , ... Introduction , The Clean ... produce fuel with increased oxygen content. Oxygenated fuel is desirable because it burns more ...
Cached Biology Technology:Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 2Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 3Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 4Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 5Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening 2Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening 3Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening 4Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening 5Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening 6Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening 7Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening 8Analysis of Fuel Oxygenates by U.S. EPA Method 8260B Using Headspace Trap with GC/MS 2Analysis of Fuel Oxygenates by U.S. EPA Method 8260B Using Headspace Trap with GC/MS 3Analysis of Fuel Oxygenates by U.S. EPA Method 8260B Using Headspace Trap with GC/MS 4