Navigation Links
CSHL team helps Neandertal Genome Project compare differences between Neandertals and modern humans
Date:5/6/2010

ke in our Neandertal relatives.

"The overwhelming majority of chimp proteins about 75% -- are different from ours in at least one amino-acid 'letter," according to Hannon. These amino-acid changes are in most instances slight, but the resulting functional differences the way they affect what proteins do in cells can be great, and presumably help to explain many of our differences from chimpanzees.

Eighty-eight amino-acid differences and what they might signify

Hannon's team applied its focused sequencing method on those areas in the Neandertal sample obtained from Dr. Pbo, and, after several rounds of refinement, they arrived at the number 88: they found only 88 changes in Neandertal protein sequences compared with the modern human. Hannon calls this number "astonishing."

At an early stage of the study, the team identified many more protein differences -- about 1000 -- between modern man and the specific Neandertal individual sampled, a male who died about 49,000 years ago in a cave called El Sidrn, in Spain. But that initial figure was based on comparing the Neandertal sequence to that of the modern human reference genome. When the teams incorporated into their calculations variations in the modern human code that they catalogued in 50 individuals from a range of modern ethnic groups, the number of human-Neandertal protein differences dropped from over 1000 to only 88.

Although Hannon says it will be important to study the functional role of the 88 proteins, he expects that many may prove "neutral," functionally. These would be changes in the genetic code that do not issue in any difference in the function of the associated proteins. If even more human genome samples -- say, from 500 contemporary individuals rather than 50 -- were included in the comparison, the number of differences might drop again, Hannon believes. And if additional Neandertal samples were factored into the comparison, he says,
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. 4-D software helps adjust for breathing when treating lung cancer with radiotherapy
2. New tool helps scientists see molecular signals of eye disease before symptoms arise
3. U.S. Preventive Medicine Helps Participants of the State of Nevada Public Employees Benefits Program (PEBP) Become Healthier
4. Social networking helps hermit crabs find homes
5. New Scripps Research and GNF study helps explain how we can sense temperatures
6. Hops helps reduce ammonia produced by cattle
7. Common PGR helps creeping bentgrass weather drought
8. Eating like a bird helps forests grow
9. Young salamanders movement over land helps stabilize populations
10. New mathematical model helps biologists understand how coral dies in warming waters
11. New assay helps track termites and other insects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... 2014 The Defense Logistics Agency is ... detect and prevent counterfeit microcircuits from entering into ... started performing an in-house microcircuit anti-counterfeit initiative dubbed ... of purchased microcircuits while increasing their reliability throughout ... will be conducted at DLA,s Electronics Product Test ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ... and robust – with the clinical data to back ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... an independent global commission of eminent scientists states that ... meet current and future threats to food security and ... Climate Change today released a Summary for Policy Makers ... of feeding the world in the face of climate ...
... Experts from Rusk Institute of Rehabilitation Medicine at ... clinical insight into complex medical rehabilitation, the treatment ... handheld technologies into practice management at the American ... Meeting in Orlando, November 17-20, 2011. Experts will ...
... is present in all vegetative matter that can be ... their own fuel. Last year, global biofuel production reached ... of the world,s transportation fuel. Bioethanol, a popular type ... such as corn and sugarcane. However, technologies are being ...
Cached Biology News:Global commission delivers food security policy recommendations 2Global commission delivers food security policy recommendations 3Rusk experts present at American Association of Physical Medicine and Rehabilitation meeting 2Toward more cost-effective production of biofuels from plant lignocellulosic biomass 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... following Webcast:, What: Transgenomic Inc. Fourth Quarter ... Conference Call, When: Thursday, February 28, 2008 ... How: Live over the Internet -- Simply log ... address above., To access the call via telephone, call ...
... 28 Memory,Pharmaceuticals Corp. (Nasdaq: MEMY ) announced today that it ... March,6, 2008, before the U.S. financial markets open. Management will provide a,Company ... 6, 2008, at 9:00 a.m. EST., Investors and ... ...
... New England Journal of Medicine, led by researchers at ... University of Massachusetts Medical School (UMMS), indicates a declining ... the first demonstration of a link between two independent ... has offered universal newborn screening to detect cystic fibrosis ...
Cached Biology Technology:Memory Pharmaceuticals to Announce Fourth Quarter and Full Year 2007 Results on Thursday, March 6, 2008 2Data show a decline in cystic fibrosis since introduction of prenatal carrier screening 2
... The lyophilization stabilizer is designed ... process and for long-term storage. ... toxic ingredients. It is a ... pH 7.2, and is superior to ...
... coating stabilizer is designed for stabilizing ... and antibodies for immunoassay development. ... during the coating and drying process ... It can also works as a ...
... Clinical is Tecans open platform for clinical ... safety and performance in the clinical diagnostic ... by flexible barcode reading and sample traceability ... the system complies with the IVD-Directive* established ...
... the smallest thermal cyclers on the market, which ... 0.5ml (20 samples) or 0.2ml microtube (25 samples) ... and cooling rate of 3.6C/sec and 2.0C/sec respectively ... Fast track programming with new quick dial facility ...
Biology Products: