Navigation Links
CSHL team helps Neandertal Genome Project compare differences between Neandertals and modern humans
Date:5/6/2010

ke in our Neandertal relatives.

"The overwhelming majority of chimp proteins about 75% -- are different from ours in at least one amino-acid 'letter," according to Hannon. These amino-acid changes are in most instances slight, but the resulting functional differences the way they affect what proteins do in cells can be great, and presumably help to explain many of our differences from chimpanzees.

Eighty-eight amino-acid differences and what they might signify

Hannon's team applied its focused sequencing method on those areas in the Neandertal sample obtained from Dr. Pbo, and, after several rounds of refinement, they arrived at the number 88: they found only 88 changes in Neandertal protein sequences compared with the modern human. Hannon calls this number "astonishing."

At an early stage of the study, the team identified many more protein differences -- about 1000 -- between modern man and the specific Neandertal individual sampled, a male who died about 49,000 years ago in a cave called El Sidrn, in Spain. But that initial figure was based on comparing the Neandertal sequence to that of the modern human reference genome. When the teams incorporated into their calculations variations in the modern human code that they catalogued in 50 individuals from a range of modern ethnic groups, the number of human-Neandertal protein differences dropped from over 1000 to only 88.

Although Hannon says it will be important to study the functional role of the 88 proteins, he expects that many may prove "neutral," functionally. These would be changes in the genetic code that do not issue in any difference in the function of the associated proteins. If even more human genome samples -- say, from 500 contemporary individuals rather than 50 -- were included in the comparison, the number of differences might drop again, Hannon believes. And if additional Neandertal samples were factored into the comparison, he says,
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. 4-D software helps adjust for breathing when treating lung cancer with radiotherapy
2. New tool helps scientists see molecular signals of eye disease before symptoms arise
3. U.S. Preventive Medicine Helps Participants of the State of Nevada Public Employees Benefits Program (PEBP) Become Healthier
4. Social networking helps hermit crabs find homes
5. New Scripps Research and GNF study helps explain how we can sense temperatures
6. Hops helps reduce ammonia produced by cattle
7. Common PGR helps creeping bentgrass weather drought
8. Eating like a bird helps forests grow
9. Young salamanders movement over land helps stabilize populations
10. New mathematical model helps biologists understand how coral dies in warming waters
11. New assay helps track termites and other insects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... May 19, 2015 ... the addition of the  "Genetic Testing Market ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, Genetic ... analysis of the current and future genetic ... tests, their working principles and types are ...
(Date:5/14/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ) has ... in Smart Mobile Devices " report to their ... a watershed year for fingerprint sensors in smartphones and ... gave fingerprint sensors a raison d,etre in the mobile ... a must-have feature in flagship smartphones. The ...
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced the appointment of ... Chief Financial Officer, reporting to Rick Bergman ... current Chief Financial Officer, Kathleen Bayless , ... Mr. Ali brings extensive financial management ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... fruit fly and then moving into mice and humans, researchers at ... gene suppresses cancer in all three organisms. Reciprocally, switching off the ... leads to cancer. The authors show there is a good chance ... They report their findings in two papers in the leading online ...
... from Queen,s University are in India today (Monday) to ... infections which destroy plants and animals. The biotechonology ... of research into the infections which cost the world ... $5.3 billion in animal health each year. A ...
... algorithm that meshes existing data to produce a ... to stimuli. Using this new method, Whitehead Institute ... alpha-synuclein toxicity to identify genes and pathways that ... alpha-synuclein protein in brain cells are a hallmark ...
Cached Biology News:Suppressing cancer with a master control gene 2Reduction in parasite infections ahead for India 2Calculating gene and protein connections in a Parkinson's disease model 2Calculating gene and protein connections in a Parkinson's disease model 3Calculating gene and protein connections in a Parkinson's disease model 4
(Date:5/22/2015)... -- According to a new market research ... Electrophoresis, Agarose & Polyacrylamide Gel, Capillary Electrophoresis, Isoelectric Focusing, ... by End User - Global Forecast to 2020", published ... around $1.98 Billion by 2020 with a CAGR of ... Browse 226 ma rket data T ...
(Date:5/22/2015)... 22, 2015 Baylor Research Institute (BRI) ... Genomics Research Institute (TGen) in Phoenix, AZ ... accelerating early detection and treatments for patients with a broad ... will lead to new clinical trials and access to technology ... gap from bench to bedside across Baylor Scott ...
(Date:5/21/2015)... Specialty Pharmacy Times has completed ... to BPA Worldwide as a business publication member. ... data for Specialty Pharmacy Times based on business/distribution, ... a member of BPA Worldwide, Specialty Pharmacy Times ... with the most reliable, unequaled data,” said Chris ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 uBiome, ... announced a partnership with PicnicHealth, a healthcare company ... Participants diagnosed with Inflammatory Bowel Disease (IBD) will ... a complementary uBiome research kit. Both companies were ... , For more information on this ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Specialty Pharmacy Times Joins BPA Worldwide 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3
... ... User Interface and Improved Support for Complex Experiments. , ... (PRWEB) April 12, 2010 -- Genedata, a leading ... Genedata Screener® 8. Developed over the past year to address evolving customer requirements, Genedata ...
... of carbon, is a potential superstar for the electronics ... the material at nearly the speed of light ... graphene could be used to make superfast transistors ... structure exhibits incredible flexibility and mechanical strength, as well ...
... ... Europe for Popular RAPS Workshop on Electronic Regulatory Submissions , ... Rockville, MD (Vocus) April 8, 2010 -- ... Professionals Society (RAPS) will host Preparing Compliant eCTD Submissions in Brussels, 5–7 May. This ...
Cached Biology Technology:Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 2Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 3Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 4Graphene films clear major fabrication hurdle 2Graphene films clear major fabrication hurdle 3RAPS to Host eCTD Submissions Workshop in Brussels 2RAPS to Host eCTD Submissions Workshop in Brussels 3
sodium channel, nonvoltage-gated 1 alpha,...
ANTI PIG LDH H4...
... use in refrigerators, freezers, or liquid nitrogen. Conveniently sized ... for color coding to project, user, lab, etc. Holes ... cool air circulation. Supplied with 9 x 9 (12.7 ... Box dimensions: 13 x 13 x 5.1 cm H ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Biology Products: