Navigation Links
CSHL team develops mouse models of leukemia that predict response to chemotherapy
Date:3/31/2009

. This incorrect fusion is thought to create cancer-causing genes, or "oncogenes," that encode so-called fusion proteins. It's the proteins that are the most immediate "cause" of cancer. They profoundly disturb the developmental program of cells.

Both oncogenic mutations identified by Lowe's team in AML patients have been well studied. The oncogene AML1/ETO previously has been associated with a favorable therapeutic outcome in people, while fusion oncogenes involving the MLL gene have been associated with an adverse outcome. To design an animal model that predicts these outcomes, the team introduced each mutation individually into stem and progenitor cells along with another oncogene, called Nras, which also appears frequently in human AML and is commonly found in concert with AML1/ETO and MLL fusion genes.

These altered stem cells were transplanted into mice that were first treated with radiation to destroy existing bone marrow cells. The altered stem cells then took over the "host" bone marrow and promoted the development of leukemia. To track leukemia onset and response to therapy, the scientists tagged all leukemia cells with a gene from fireflies that encodes an enzyme called luciferase, which makes leukemia cells glow and detectable by a ultrasensitive camera. Within weeks, the mice developed leukemias that showed the same genetic and pathological features as human AML.

"We were therefore certain," says Lowe, "that these animals were good models for studying the impact of cancer's genetic heterogeneity on therapy response and getting a correct read-out in terms of outcome prediction."

Sensitivity vs. resistance to chemotherapy

Experiments in which the team treated the mice with the same chemotherapy regimen administered to AML patients have proved Lowe to be correct. Just as in humans, leukemias in mice that received the AML1/ETO oncogene were also sensitive to chemotherapy and soon regressed, whereas ML
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. MIT student develops new innovations to selectively kill cancer cells
2. When acute hepatitis develops into chronic hepatitis
3. Fujitsu Develops HDD Security Technology Based on Opal SSC Standards
4. MIT develops new way to fuse cells
5. Hypertension develops early, silently, in African-American men
6. Iowa State researcher develops new treatment method for canine eye diseases
7. Lighting research center develops framework for assessing light pollution
8. AgriLife Research breeder develops drought-tolerant corn
9. Cocaine: How addiction develops
10. UCF professor develops vaccine to protect against black plague bioterror attack
11. Consortium develops new method enabling routine targeted gene modification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays ... a while. Hypertension – the medical term for high blood ... early 1800s, and the inflatable cuff that,s used in measuring ... however, mean there,s nothing new about hypertension, its triggers and ... beliefs about the condition and the best ways to treat ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center ... for its School of Medicine. Funding for this $50 ... campaign that will be publicly launched next summer. ... in the former 60 series R.J. Reynolds Tobacco Company ... Construction will begin immediately with plans to be ready ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased emphasis ... investments in new testing and inspection technologies. The ... rise to a range of innovative test solutions. ... of Generation Y, which is generally more inclined ... result, product development strategies of test equipment vendors ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... as the plaque that gunks up neurons in ... Creutzfeldt-Jacob disease--the human analog of mad cow disease. ... in a host of conditions, researchers haven't been ... techniques used to image proteins, such as X-ray ...
... of insulin, as is found in many people with obesity ... energy release into the body, according to researchers at the ... findings, which may point to new approaches to developing improved ... September 22 issue of the journal Nature. , The research ...
... or RNA, has long been thought to be important only ... cells' workhorses. But new evidence shows that tiny bits of ... in normal biology and in the development of cancers. , ... these tiny RNAs, known as microRNAs, is only supposed to ...
Cached Biology News:Unweaving amyloid fibers to solve prion puzzles 2Unweaving amyloid fibers to solve prion puzzles 3UCSD study clarifies insulin's role in blocking release of energy in patients with type II diabetes 2Once given 'no respect,' cells' tiny RNAS take driver's seat 2Once given 'no respect,' cells' tiny RNAS take driver's seat 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Wis. - For the second time this year, a ... stock for sale to the public. Called an initial public ... to the companies and investors who are directly involved, but ... NimbleGen , a Madison-based biotechnology company, has filed papers with ...
... to experience high rates of failure. As a result, ... valued partner. The result stifles innovation, growth, and a ... requires shedding the flawed processes of yesterday, and introducing ... by promising incremental delivery of functional software. , , ...
... - Now that two companies he once owned ... strategy, Brian Wiegand's days as a self-described serial entrepreneur ... NameProtect , a developer of digital brand management ... of Wilmington, Del. , ,He will concentrate on ...
Cached Biology Technology:Wisconsin IPOs are a harbinger of growing tech economy 2Wisconsin IPOs are a harbinger of growing tech economy 3Agile Revolution: A new era of software delivery 2Agile Revolution: A new era of software delivery 3Agile Revolution: A new era of software delivery 4NameProtect sold, tech entrepreneur to focus on Jellyfish.com 2
RAT ANTI MOUSE JAM-2 Immunogen: Recombinant soluble JAM-2...
casein kinase 2, alpha 1 polypeptide, transcript variant 2, mRNA (cDNA clone MGC:15232 IMAGE:4121882), complete cds...
... complementary RNA Spikes for the normalization and ... array printing and for protocol assessment and ... hybridization stringency and background. Normalize Cy3 and ... Oligo Spots, and complementary RNA Spikes for ...
Kit for Detection of Mitochondrial Membrane Potential...
Biology Products: