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CSHL study finds that 2 non-coding RNAs trigger formation of a nuclear subcompartment
Date:12/19/2010

itysuch as during cell division or when the scientists added drugs that block RNA transcription or specifically switched off the MEN genesthe newly formed paraspeckles fell apart.

This dependency on RNA transcription seems to be unique, as other nuclear compartments such as Cajal bodies can form when one of their components is simply tethered to a site on the genome, which in turn causes other components to coalesce around it. In contrast, says Spector, "Paraspeckles seem to follow a different assembly model in which MEN non-coding RNAs serve as seeding molecules that are driven by transcription to recruit the other components."


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Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

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