Navigation Links
CSHL study finds that 2 non-coding RNAs trigger formation of a nuclear subcompartment
Date:12/19/2010

Cold Spring Harbor, N.Y. The nucleus of a cell, which houses the cell's DNA, is also home to many structures that are not bound by a membrane but nevertheless exist as distinct compartments. A team of Cold Spring Harbor Laboratory (CSHL) scientists has discovered that the formation of one of these nuclear subcompartments, called paraspeckles, is triggered by a pair of RNA molecules, which also maintain its structural integrity.

As reported in a study published online ahead of print on December 19 in Nature Cell Biology, the scientists discovered this unique structure-building role for the RNAs by keeping a close watch on them from the moment they come into existence within a cell's nucleus. The scientists' visual surveillance revealed that when the genes for these RNAs are switched on, and the RNAs are made, they recruit other RNA and protein components and serve as a scaffolding platform upon which these components assemble to form paraspeckles.

The two RNAs described in the study, named MENε and MENβ, are "non-coding" RNAs a type of RNA that does not serve as a code or template for the synthesis of cellular proteins. The genes that give rise to these non-coding RNAs are now thought to make up most of the human genome, in contrast to the genes that produce protein-coding RNAs, which account for approximately 2% of the human genome.

"We've known for several years that much of the other 98% of the genome doesn't encode for useless RNA," explains CSHL's Professor David L. Spector, who led the current study. "Various types of non-coding RNAs have been found that regulate the activity of protein-coding genes and cellular physiology in different ways. Our results reveal a new and intriguing function for a non-coding RNAthe ability to trigger the assembly and maintenance of a nuclear body."

The nuclear bodies in questionthe paraspecklesare believed to serve as nuclear storage depots for RNAs that are ready to be
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... to acquire and creatively manipulate spoken language is unique ... past 6 million years of human evolution to make ... best candidate gene we now have," says Wolfgang Enard, ... his efforts to understand the molecular biological basis of ... The results of his latest study, undertaken in collaboration ...
(Date:9/18/2014)... happy-go-lucky characters, so you might expect that most would ... fact some dogs are distinctly more pessimistic than others, ... "This research is exciting because it measures positive and ... offers researchers and dog owners an insight into the ... Melissa Starling, from the Faculty of Veterinary Science. Her ...
(Date:9/18/2014)... that when people are too stressed they are often ... Brain Mind Institute (BMI) at EPFL have just highlighted ... chronic stress and the loss of social skills and ... a synaptic regulatory molecule in the brain. This was ... . , Carmen Sandi,s team went to look ...
Breaking Biology News(10 mins):Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3Dogs can be pessimists too 2Dogs can be pessimists too 3How stress tears us apart 2
... For Immediate Release A group of researchers at ... Institute has published a paper that reviews new strategies ... whether people are predisposed to developing common conditions like ... age, the entire DNA sequences, or "genomes," of humans ...
... immune cell that directs other cells to fight infection ... in both health and disease. Researchers from the University ... stimulatory molecule and a protein found on the membrane ... multi-taskers of sorts. Th17 cells protect the body against ...
... ARLINGTON, Va. - To expand collaboration and initiatives, the ... be held Nov. 8-10, will explore a wide range ... explosive devices. Hosted by the Office of Naval ... Hyatt Regency in Crystal City, Va., and will feature ...
Cached Biology News:Scientists describe new approach for identifying genetic markers for common diseases 2Scientists describe new approach for identifying genetic markers for common diseases 3Penn study shows 2-sided immune cell could be harnessed to shrink tumors 2
(Date:9/18/2014)... , September 18, 2014 ... ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the ... - Global Strategic Business Report" ... http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the worldwide ... Million by the following Product Segments: ...
(Date:9/18/2014)... -- Research and Markets has announced ... Report 2014" report to their offering. ... is a professional and in-depth study on the ... The report provides a basic overview of ... chain structure. The N-acetylcysteine market analysis is provided ...
(Date:9/18/2014)... Sept. 18, 2014  U.S. biotech company Kultevat ... exclusive license for technology developed by the Donald ... in plants, including for applications in production of natural ... The technology was developed under the direction of ... and former president of the Danforth Plant Science Center, ...
(Date:9/18/2014)... , Pennsylvanie, 18 septembre 2014 ... en 1974, a été depuis 40 ... les évaluations cliniques traditionnelles par des évaluations ... et sur les impacts économiques des traitements. ... A cours d,une récente ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 21974 - 2014 - Mapi fĂȘte ses 40 ans 2
... Agencourt offers primer walking sequencing of PCR products, plasmid inserts , ... in either raw or , purified form and ... Select from either single stranded coverage for confirmation sequencing , ... purposes. , ...
... , , ... sequence delineation on capillary electrophoresis, instrumentation. CleanSEQ has ... system with the, ABI 3700 and 3730xl sequencers. ... prone to evaporation and exposure to, air before ...
... , Agencourts RNAClean kit provides a ... purifying nucleic acid products generated in common enzymatic , ... formatted for microarray , gene expression analysis experiments ... automated formats. RNAClean eliminates the need for vacuum filtration or , ...
Cached Biology Technology:Primer Walking 2CleanSEQ on the ABI 3100 2CleanSEQ on the ABI 3100 3CleanSEQ on the ABI 3100 4RNAClean - RNA & cDNA in vitro Reaction Purification 2
Request Info...
Candida (IgG) -Ab EIA Sample Size: 5 l...
... Oxidized LDL (Competitive) EIA Principle: The ... monoclonal antibody 4E6. Oxidized LDL in the sample ... bound to the microtiter well for the binding ... washing st Sample Size: 25 l ...
... used with its manganese-containing reaction buffer, converts ... of short (1825 bp) interfering RNAs (siRNA) ... 1.3 units (1 l) of ShortCut RNase ... of dsRNA into siRNA suitable for RNA ...
Biology Products: