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CSHL study finds short- and long-term memories require same gene but in different circuits
Date:8/17/2009

the other, but the set that lags behind consolidates the memory and stores it long-term.

Why two mechanisms?

But why might the fly brain divide up the labor of storing different memory phases this way? Dubnau's hunch is that it might be because for every stimulus it receives, the brain creates its own representation of this information. And each time this stimulus for example, an odor is perceived again, the brain adds to the representation and modifies it. "Such modifications might eventually disrupt the brain's ability to accurately remember that information," Dubnau speculates. "It might be better to store long-term memories in a different place where there's no such flux."

The team's next mission is to determine how much cross talk, if any, is required between the two lobes for long-term memory to get consolidated. This work will add to the progress that scientists have already made in treating memory deficits in humans with drugs aimed at molecular members of the rutabaga-signaling pathway to enhance its downstream effects.


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Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

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