Navigation Links
CSHL study finds short- and long-term memories require same gene but in different circuits
Date:8/17/2009

rutabaga genes learn to associate the odor with the shock and if given a choice, buzz away from the grid. But flies that carry a mutated version of rutabaga in their brains lack both short- and long-term memory, don't learn the association, and so fail to avoid the shocks.

The team has now found, however, that this total memory deficit does not occur when flies carry the mutated version in either the γ or in the αβ lobes. Flies in which normal rutabaga function was restored within the γ lobe alone regained short-term memory but not long-term memory. Restoring the gene's function in the αβ lobe alone restored long-term memory, but not short-term memory.

Long- and short-term memory involve different circuits

"This ability to independently restore either short- or long-term memory depending on where rutabaga is expressed supports the idea that there are different anatomical and circuit requirements for different stages of memory," Dubnau explains. It also challenges a previously held notion that neurons that form short-term memory are also involved in storing long-term memory.

Previous biochemical studies have suggested that rapid, short-lived signals characteristic of short-term memory cause unstable changes in a neuron's connectivity that are then stabilized by slower, long-lasting signals that help establish long-term memory in the same neuron. But anatomy studies have long hinted at different circuits. Surgical lesions that destroy different parts of an animal's brain can separately disrupt the two kinds of memory, suggesting that the two memory types might involve different neuronal populations.

"We've now used genetics as a finer scalpel than surgery to reconcile these findings," Dubnau says. His team's results suggest that biochemical signaling for both types of memory are triggered at the same time, but in different neuron sets. Memory traces form more quickly in one set than
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Water quality improves after lawn fertilizer ban, study shows
2. Study supports DNA repair-blocker research in cancer therapy
3. K-State lab gives researchers the tools to study porcine circovirus associated diseases
4. New study shows that cocoa flavanols can be preserved during cooking and baking
5. New study suggests possible genetic links between environmental toxins and multiple myeloma
6. New study reveals unexpected relationship between climate warming and advancing treelines
7. Stimulus funding helps K-State biochemist study eyes lens in diabetes, galactosemia patients
8. U of M study identifies risk factors of disordered eating in overweight youth
9. K-State researcher, collaborators study virulence of pandemic H1N1 virus
10. Study links virus to some cases of common skin cancer
11. Douglas-fir, geoducks make strange bedfellows in studying climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... BLUE BELL, Pa. , July 2, 2014  Unisys ... The Netherlands , Unisys Nederland N.V., today announced that ... (DJI) to deliver, implement and manage a new Basic Provision ... . Unisys won the contract with a ... for identity management software. The term of the contract is ...
(Date:7/10/2014)... DALLAS , July 3, 2014 ... Sensors Market by Type (Swipe And Area), Material (Optical ... Defense, Healthcare, Commercial Security and Banking & Finance), and ... 2020", published by MarketsandMarkets, the global Fingerprint Sensors Market ... at a high CAGR of 16.8% from 2014 to ...
(Date:7/10/2014)... 2014 According to a new ... Control Systems Market Global Forecast, Market Share, Size, Growth ... Access Control systems market was valued at USD 15,406.1 ... a CAGR of 12.6% from 2014 to 2019, to ... 2019. Browse the full Electronic Access Control ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... , BETHESDA, Md., June 24, 2010 The National ... five-year grant to the American Society for Biochemistry and ... for educators across the nation. The initiative aims ... by establishing foundational concepts and skills for the discipline ...
... grow with less fertilizer, herbicide, fuel, and erosion than ... according to researchers writing in the current issue of ... be one of the largest innovations in the 10,000 ... with the right breeding programs, said John Reganold, Washington ...
... University biomedical engineers and researchers from the University of ... device that is powerful enough to let doctors easily ... the LCD monitor on the back of the camera. ... camera were published online this week in the open-access ...
Cached Biology News:NSF grant will develop new online hub for biochemistry, molecular biology educators 2Agriculture's next revolution -- perennial grain -- within sight 2Off-the-shelf cancer detection 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 Terascala, the ... announced that Alan Swahn, a former vice president of ... team as vice president of marketing. Terascala’s software when ... and NetApp create the highest performance and most reliable ... appointed to guide Terascala’s channel expansion and broaden its ...
(Date:7/10/2014)... Senior supply chain management executives from over ... challenges of “Reducing Cost, Lead Time, & Defects in ... Describing the partnership of the Bio Supply Management Alliance ... ( SCMI) of the University of San Diego ... Kroc Institute of Peace and Justice in San Diego, ...
(Date:7/10/2014)... July 10, 2014 Research and Markets ... the "International Photonic Integrated Circuit (Monolithic Integration, ... 2019" report to their offering. ... concept of photonic integration traces its roots in ... promise of photonic integration went unexplored and unfulfilled ...
(Date:7/10/2014)... PNAS (Proceedings of the National Academy of Sciences) ... deprivation have a significant effect on our metabolism. The ... time of day to test for diseases such as ... , Researchers from the University of Surrey and The ... sleep deprivation, body clock disruption and metabolism, and discovered ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2
... Oct. 3 Thermo Fisher,Scientific Inc. (NYSE: ... has acquired Priority,Solutions International, a leading third-party ... following anti-trust clearance.,Priority Solutions was previously majority-owned ... $95 million in 2006, Priority,Solutions offers a ...
... equity stake in Zenotech Laboratories to 45%, GURGAON, ... Laboratories Limited (Zenotech) today announced the,signing of Definitive Agreements, ... its current 7% to 45% at a price of ... involves: (a) Purchase of shares from the existing ...
... With a special eye for the,details hidden from ... Mara G. Aspinall. Photographs of architectural details from beaches,to ... the fore. The,collection includes images from seven different countries., ... Aspinall, the,president of Genzyme Genetics, is also a talented ...
Cached Biology Technology:Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 2Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 3Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 4Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 3An Uncommon Eye: Photography Exhibit by Biotechnology Executive at BHCC Gallery 2
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Tumor Suppressor Sampler Kit 10 mu g each...
Monoclonal Antibody toSynapsin I a and I b Neurofilament associated protein from mouse brain extracts (4)....
Slide Chambers are convenient for performing pre-hybridization incubations and post-hybridization washes with tissue sections mounted on standard glass microscope slides. Each chamber holds up to 5 s...
Biology Products: