Navigation Links
CSHL study finds short- and long-term memories require same gene but in different circuits
Date:8/17/2009

Cold Spring Harbor, N.Y. Why is it that you can instantly recall your own phone number but have to struggle with your mental Rolodex to remember a new number you heard a few moments ago? The two tasks "feel" different because they involve two different types of memory long-term and short-term, respectively that are stored very differently in the brain. The same appears to be true across the animal kingdom, even in insects such as the fruit fly.

Assistant Professor Josh Dubnau, Ph.D., of Cold Spring Harbor Laboratory (CSHL) and his team have uncovered an important molecular and cellular basis of this difference using the fruit fly as a model. The results of their study appear in the August 25 issue of Current Biology.

The CSHL team has found that when fruit flies learn a task, each of two different groups of neurons that are part of the center of learning and memory in the fly brain simultaneously forms its own unique memory signal or trace. Both types of trace, the team discovered, depend on the activity of a gene called rutabaga, of which humans also have a similar version. A rapidly occurring, short-lived trace in a group of neurons that make up a structure called the "gamma" (γ) lobe produces a short-term memory. A slower, long-lived trace in the "alpha-beta" (αβ) lobe fixes a long-term memory.

A tale of two lobes

Neuroscientists call the rutabaga gene a coincidence detector because it codes for an enzyme whose activity levels get a big boost when a fly perceives two stimuli that it has to learn to associate with one another. This enzymatic activity in turn signals to other genes critical for learning and memory.

A classic experiment that teaches flies to associate stimuli and one that the CSHL team used is to place them in a training tube attached to an electric grid, and to administer shocks through the grid right after a certain odor is piped into the tube. Flies with normal
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Water quality improves after lawn fertilizer ban, study shows
2. Study supports DNA repair-blocker research in cancer therapy
3. K-State lab gives researchers the tools to study porcine circovirus associated diseases
4. New study shows that cocoa flavanols can be preserved during cooking and baking
5. New study suggests possible genetic links between environmental toxins and multiple myeloma
6. New study reveals unexpected relationship between climate warming and advancing treelines
7. Stimulus funding helps K-State biochemist study eyes lens in diabetes, galactosemia patients
8. U of M study identifies risk factors of disordered eating in overweight youth
9. K-State researcher, collaborators study virulence of pandemic H1N1 virus
10. Study links virus to some cases of common skin cancer
11. Douglas-fir, geoducks make strange bedfellows in studying climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market, ... Apollo Robbins for the 2015 International CES debut ... Apollo Robbins will be at the NXT-ID booth January ...
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has announced the ... Apple/AuthenTec TMDR92 & Sapphire - Technology Report" report ... Following the acquisition of AuthenTec in ... the iPhone 5S. It is currently the only device ...
(Date:12/19/2014)... VEGAS , Dec. 18, 2014   LaunchKey , ... for the post-password and Internet of Things era, today ... funding. The venture round was led by Metamorphic Ventures ... Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey has raised ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... expensive sole fillets or cod caught in the North Sea ... examples of types of fraud in the fisheries sector. A ... based on genetics, genomics, chemistry and forensics - can provide ... fish product come from.where was this fish caught.is it wild ...
... (May 26, 2011) The New York Stem Cell ... cures for major diseases through stem cell research ... by NYSCF Robertson Investigator Dr. Marius Wernig, that ... neurons. These neurons will allow researchers to ...
... cystic fibrosis could help combat other antibiotic-resistant microbes, according ... Continuous use of existing antibiotics means that resistant bacteria ... world. New antibiotics are urgently needed to combat the ... Now a surprising source of hope has ...
Cached Biology News:What fish is on your plate? 2Cystic fibrosis bacteria could help fight back against antibiotic resistance 2
(Date:1/22/2015)... , a precision medicine software company that has developed a ... genomic, imaging and other biomedical data in research and clinical ... CEO of Aspera, an IBM Company, to its board as ... "We are pleased to welcome Michelle to ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... Solutions , Inc. (NASDAQ: BLFS ), a leading ... storage and cryopreservation freeze media and ... or the "Company"), today announced that it will hold its ... "Annual Meeting"). Because the expected date for the ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... Medical Inc.,(NYSE: SMA ), an independent provider of ... markets, announced today that the board,of directors has voted ... five,to seven. It has appointed two new independent directors, ... positions, bringing the total of,independent directors to six., ...
... believes many cardiac arrests experienced by fire fighters may be ... attributable to ... MASI ),the inventor of Pulse CO-Oximetry and Read-Through Motion and Low ... has issued education materials to more than 3,000 local,union presidents in ...
... Looks to CMM for,Professional Services in Finding Genetic ... Mich., Jan. 8 The Center for Molecular,Medicine ... the Children,s,Oncology Group (COG) to provide professional genotyping ... evaluate the existence of genetic,abnormalities and their association ...
Cached Biology Technology:Symmetry Medical Expands Board of Directors 2Symmetry Medical Expands Board of Directors 3International Association of Fire Fighters (IAFF) Advocates Screening Fire Fighters for Carbon Monoxide Poisoning Using Pulse CO-Oximetry 2International Association of Fire Fighters (IAFF) Advocates Screening Fire Fighters for Carbon Monoxide Poisoning Using Pulse CO-Oximetry 3International Association of Fire Fighters (IAFF) Advocates Screening Fire Fighters for Carbon Monoxide Poisoning Using Pulse CO-Oximetry 4International Association of Fire Fighters (IAFF) Advocates Screening Fire Fighters for Carbon Monoxide Poisoning Using Pulse CO-Oximetry 5Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study 2Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study 3Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study 4
No description available in Ensembl Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: