Navigation Links
CSHL scientists uncover role of protein critical for activating DNA replication
Date:1/7/2010

interacts with its collaborators. Having found out previously that DDK targets a multi-subunit protein complex called MCM, they've now narrowed down DDK's binding site to a domain within one of the subunits, Mcm4, where it phosphorylates a series of amino acidsprotein building blocksthat otherwise inhibit Mcm4 from functioning.

The discovery of this self-inhibitory activity within Mcm4 and the finding that DDK is required to overcome it was a surprise, according to the authors. They propose that such complexity might have evolved in response to the importance of precision and accuracy of DNA replication.

"Although this is the only essential role for DDK under normal conditions, we have found that DDK takes on another task when the cell suffers DNA damage," says Dr. Stillman. In this hazardous situation, he and his colleague found, DDK activates an S-phase checkpoint mechanism that halts the DNA copying process and initiates DNA repair.

"This discovery of these distinct functions of DDK represents a key piece of the puzzle of how the initiation of DNA replication is coordinated and controlled by kinase proteins," says Dr. Stillman.


'/>"/>

Contact: Hema Bashyam
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists breakthrough in production of biofuels
2. Scientists create early-warning system to defend rare Jersey cows from continental disease
3. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
4. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
5. Tarantula venom-based MD therapy to be advanced by UB scientists biotech company
6. Rice scientists divide and conquer
7. Johns Hopkins scientists discover a controller of brain circuitry
8. UCLA scientists find molecular switch to prevent Huntingtons disease in mice
9. Turtles Christmas journey tracked by scientists
10. Scientists isolate new antifreeze molecule in Alaska beetle
11. Scientists use nanosensors for first time to measure cancer biomarkers in blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... mesenchymal stem cells can stimulate neurogenesis in the brain ... (AD) and improve tissue and function injury under the ... the therapeutic effect of adipose-derived stem cells (ADSCs) transplantation ... oxidative injury and neurogenesis in the brain of AD ... Life Sciences, Tsinghua University, China transplanted ADSCs into the ...
(Date:7/11/2014)... type 1 can inhibit voltage-gated calcium channel, ... release. However, some scholars demonstrated that cannabinoid ... influx and increase neurotransmitter release. Dr. Yi ... to Tongji Medical College, Huazhong University of ... voltage-clamp and calcium imaging in cultured trigeminal ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... of years. Early explorers of Amazonian plants and animals included ... A. R. Wallace. Despite this long history of exploration, new ... of new species. The key of these discoveries lies in ... The study, published in the open access journal ...
... and spend enormous resources on the conservation of endangered ... One big problem is international legislation and the need ... networks. Zoo resources can be spent much more effectively, ... animal collections across the world,s zoos. Many zoos ...
... University of Delaware have developed a "smart" hydrogel that can ... Over the past few decades, smart hydrogels have been created ... "The idea of a smart hydrogel that can release ... professor of materials science and engineering and biomedical engineering. "What,s ...
Cached Biology News:Genes and calls reveal 5-fold greater diversity of Amazon frog species 2Scientists warn: Conservation work in zoos is too random 2Scientists warn: Conservation work in zoos is too random 3UD-developed smart gels deliver medicine on demand 2
(Date:7/10/2014)... 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, the ... announced an agreement with Lineagen, Inc., to ... NextStep Dx PLUS.  Lineagen, focused on ... disorders, currently offers FirstStep Dx PLUS, ... used by healthcare providers as a first-line ...
(Date:7/10/2014)... --  Ceres, Inc . (Nasdaq: CERE ), ... results for the three months ended May 31, 2014 ... Ceres reported that the company and its customers have ... in Brazil, which concluded in June, despite dry and ... for part of the growing season. Yields of several ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... published today in the journal PNAS (Proceedings of ... time of day and sleep deprivation have a significant ... when looking at the best time of day to ... and for administering medicines effectively. , Researchers from the ... London, investigated the links between sleep deprivation, body clock ...
Breaking Biology Technology:Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2
... will be famous for 15 minutes, couldn't imagine the influence the ... prediction. , ,With these tools, everyone can have their 15 minutes ... that 15 minutes is about all anyone has time for these ... , ,I was reminded of this after coming back from a ...
... president of Niceware International , a Milwaukee developer ... Matter has seen identification software used to track parts ... only a matter of time before healthcare facilities came ... founded in 2002, has produced NiceLabel software for the ...
... Cytochroma, Inc. , a company managed by former employees ... lawsuit filed in August 2006 by Genzyme Corp ., ... lawsuit, in which Genzyme claimed that the former Bone Care ... new products, was being adjudicated in the United States ...
Cached Biology Technology:On the Web, attention spans shrink, the need for value rises 2On the Web, attention spans shrink, the need for value rises 3Software company enters health space with RFID solutions on hold 2Software company enters health space with RFID solutions on hold 3
Epi-Grids™ Colony Grid Templates are easy-to-use griding templates that allow rapid organization of colonies from initial screening plates and for preparing precise master plates....
Detect and measure levels of mouse IgG3 antibody isotypes quickly and easily....
... of lyophilized peptide derived from the human ... GLTPSAWEASSLRSSRHSGLSHF. This peptide was used ... EP1 receptor polyclonal antibody (Catalog No. 101740) ... this antibody to block protein-antibody complex formation ...
... This goat anti-rabbit IgG FITC ... antibody' for immunofluorescent staining on tissues ... antibody is generated in rabbits. It ... controls, such as omitting the primary ...
Biology Products: