Navigation Links
CSHL scientists show in unprecedented detail how cortical nerve cells form synapses with neighbors
Date:12/21/2010

an axon, "it's searching everything." When it finds a potential partner, it then couples to the neurotransmitter machinery and the presynaptic cell begins to release neurotransmistter, to test the connection. "If the connection is good, then the beta neurexins come in and make a much tighter lock between the two nerve cells at the new synapse."

According to Huang, in comparatively simple model systems such as worms and flies, such connections are thought to be largely genetically hard-wired. "But in vertebrates, delicate structures like the hippocampus and the cerebral cortex probably require a finer system, which can respond to the organism's experiences. In other words, synaptic validation and strengthening is likely to be a learning-based system."

This suggests the connection between neurexins and other cell-adhesion molecules in the brain and neurodevelopmental disorders such as autism. A mutation in a gene called neurexin-1 and another encoding its receptor, neuroligin, have repeatedly been linked with autism in past studies. "These genes are known to be broadly expressed in many places of the nervous system," says Huang. "But the question is how and why changes in these genes leads to autism. There is some evidence that these changes do alter synapses. Our study suggests that such changes in synaptic adhesion molecules can impact a particular type of GABAergic synapse that has been shown to play an important role in regulating neural network operation."

Huang's CSHL laboratory will continue to explore the functional significance of neurexins and neuroligins in neurocircuits in living animals, and will attempt to relate changes in their expression with behavior.


'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... , May 20, 2015 NXT-ID, Inc. (NASDAQ: ... its wholly owned subsidiary, 3D-ID LLC, a company engaged ... Battelle for the biometrics technology portion of the recently ... from the Department of the Army. 3D-ID ... developed for government, law enforcement and security agencies. ...
(Date:5/14/2015)... , May 14, 2015 Research and Markets ... the "Fingerprint Sensors Market in Smart Mobile Devices ... report believes that 2014 was a watershed year for ... introduction of ,Apple Pay,. Apple gave fingerprint sensors a ... payment service. Fingerprint sensors are a must-have feature in ...
(Date:5/10/2015)... 2015 Fingerprint Cards (FPC) has received ... from the distributor World Peace Industrial Group (WPI), part of ... Asia . Deliveries are planned to take place ... smartphone manufacturers in China . The order ... guidance of + 1 000 MSEK for 2015.   ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... breakthrough in sensing at Rice University could make finding signs ... light. The technique reported in the Journal ... better medications to treat the devastating disease. The lab ... naturally attach themselves to a collection of beta amyloid proteins ...
... including stomach, liver and colon, are far more common in ... in lifestyle, such as diet and smoking, may account for ... rooted in basic biological differences between men and women. ... that treating male mice with estrogen dramatically lowers their rates ...
... COLLEGE PARK, Md. -- A new University of ... the 2009 flu pandemic (H1N1) and a common type of ... flu viruses -- with the potential for creating a new ... but University of Maryland virologist Daniel Perez, who directed the ...
Cached Biology News:Molecules 'light up' Alzheimer's roots 2Molecules 'light up' Alzheimer's roots 3Study explains why men are at higher risk for stomach cancer 2Study explains why men are at higher risk for stomach cancer 3When well-known flu strains 'hook up' dangerous progeny can result 2When well-known flu strains 'hook up' dangerous progeny can result 3
(Date:5/21/2015)... San Francisco, CA (PRWEB) May 21, 2015 ... microbiome sequencing, has announced a partnership with PicnicHealth, ... records for patients. Participants diagnosed with Inflammatory Bowel ... as well as a complementary uBiome research kit. ... Summer 2014. , For more ...
(Date:5/21/2015)... LOS ANGELES , May 21, 2015 /PRNewswire/ ... research and development company specializing in oncology, today ... 2 clinical trial with aldoxorubicin for the treatment ... of brain cancer.  The open-label, multisite trial is ... of aldoxorubicin in patients whose tumors have progressed ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Tunnell ... joined the firm as senior statistician and Principal, a ... of experience in the management and analysis of complex ... and chemical industries. , “We’re delighted to have Julia ... in data analytics,” said Dr. Philippe Cini, Group Vice ...
(Date:5/20/2015)... May 20, 2015  Select Medical Corporation ("Select") ... Trade Commission granted early termination of the waiting ... of 1976, as amended, applicable to the acquisition ... a joint venture that Select has created with ... As previously announced, MJ Acquisition Corporation has signed ...
Breaking Biology Technology:uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... VRUS ) management will present at Cowen & ... 2008 at Boston Marriott,Copley Place in Boston, MA. Schaefer ... the company on Tuesday, March 18, 2008,from 3:55 PM ... access a simultaneous webcast of Mr. Price,s overview of ...
... Inc.,(Nasdaq: ONTY ) (TSX: ONY) (the "Company") today ... 31, 2007. All results are in U.S.,dollars and prepared ... ended December 31, 2007, was $20.3 million or,$1.04 per ... $2.38,per basic and diluted share in 2006. The substantial ...
... MannKind,Corporation (Nasdaq: MNKD ) today issued the ... MannKind is absolutely committed to the continued development ... our small,patient-friendly Medtone(R) inhaler to deliver Technosphere(R) Insulin ... more closely matches the pattern,of insulin secretion seen ...
Cached Biology Technology:Pharmasset to Present at Cowen & Company's Health Care Conference on Tuesday, March 18th 2Oncothyreon reports full year and fourth quarter 2007 financial results 2Oncothyreon reports full year and fourth quarter 2007 financial results 3Oncothyreon reports full year and fourth quarter 2007 financial results 4Oncothyreon reports full year and fourth quarter 2007 financial results 5Oncothyreon reports full year and fourth quarter 2007 financial results 6Oncothyreon reports full year and fourth quarter 2007 financial results 7MannKind Corporation Response to Recent Market Events 2MannKind Corporation Response to Recent Market Events 3MannKind Corporation Response to Recent Market Events 4MannKind Corporation Response to Recent Market Events 5MannKind Corporation Response to Recent Market Events 6
... results - with a modular approach to ... The ChemStation Plus NDS family provides modular ... and data management, giving you the flexibility ... labs needs now and that can grow ...
... 'Agilents GeneSpring Workgroup solution is ... managing and mining expression data in ... and is deployed in over 40 ... research organizations worldwide. GeneSpring Workgroup streamlines ...
... proteomic scale kinase profiling, quantitative measurement ... discovery research built on the flexible ... platform. These microarrays are available as ... Substrate - Peptide Microarray Service. ...
... PEP-165 is an 18 amino acid synthetic peptide whose sequences are ... is (amino to carboxy terminus): S(21) - S - M - ... - E - A - I - D - K - ... This peptide may be used for neutralization and control ...
Biology Products: