Navigation Links
CSHL scientists reveal mechanism behind 'oncogene addiction' in acute leukemia
Date:7/31/2011

her the underlying genetic program in unprecedented detail. The central player orchestrating these cancer-specific self-renewal programs was found to be Myb, a protein known to regulate normal blood cell production that previously also has been implicated in certain subtypes of leukemia.

"MLL-AF9 apparently 'hijacks' Myb to enforce a program of aberrant self-renewal," explains Amy Rappaport, who was a co-first author on the paper, with Johannes Zuber. The team also included Christopher Vakoc, a CSHL Fellow, among others. "The consequences of inhibiting Myb in established leukemia were striking," says Zuber. "Following Myb suppression, mouse leukemia cells invariably lost their aberrant self-renewal ability, resumed their normal cell fate, maturing into white blood cells, and eventually got eliminated." As a consequence, mice harboring this aggressive and chemotherapy-resistant form of AML were cured by inhibiting Myb. The protein's suppression had no adverse impact upon normal white blood cells.

To identify and study genes that are specifically required in cancer cells, the researchers took a systematic approach that demonstrates the power of a series of technological advances made by Lowe's group in concert with several other groups at CSHL. These advances play an important role in CSHL's new Cancer Therapeutic Initiative. The Initiative aims to rapidly identify new therapeutic targets and validate them in mouse models specific for genetic subtypes of human cancer.

In the paper published today, Lowe's team first implemented a rapid strategy to introduce common human AML mutations in mice so that they closely mimicked human AML, both in terms of symptoms and response to treatment. These genetically reprogrammed mice are called "mosaic mice." As a next step, the team used a genetic switch to inactivate the oncogene that gives rise to the "addictive" MLL-AF9 oncoprotein. When MLL-AF9 was suppressed in living mice, the cancers shrank
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists take a giant step for people -- with plants!
2. Scientists report dramatic carbon loss from massive Arctic wildfire
3. Toucans wearing GPS backpacks help Smithsonian scientists study seed dispersal
4. 12 scientists named ASBMB award winners
5. Think healthy, eat healthy: Caltech scientists show link between attention and self-control
6. Scientists design nano-sized drug transporter to fight disease
7. Life scientists use novel technique to produce genetic map for African Americans
8. Fools gold gives scientists priceless insight into Earths evolution
9. A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
10. UCLA scientists complete first mapping of molecule found in human embryonic stem cells
11. Cutting-edge imaging techniques for neuroscientists available in latest laboratory manual
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014  HITLAB SM announced today its ... to confirm its adherence to current U.S. Food ... HITLAB to conduct regulated smart device and smart ... patient safety and research quality. "HITLAB ... and delivery with innovative technology," said Laura ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in ... sensors in biomedical applications. Chemical sensors help in ... diagnosis during surgical procedures. The Global Chemical Sensor ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology ... system measures the overall facial feature of a ... the distance between eyes. Facial recognition is used ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... won the "Most Creative Visualization" award in the "commercial" ... achievement we are extremely proud of. iDEA is Illumina,s ... new and creative visualization and data analysis techniques. ... very first moment we heard about it. Genomatix is ...
... Kan. -- Preliminary research at Kansas State University may make ... scientists believe that cellulose, the most common organic compound on ... biofuels -- if a procedure to effectively break it down ... gives plants their rigidity. Kathrin Schrick, assistant professor in ...
... This press release is available in Spanish ... waters of the European Atlantic Ocean and, nevertheless, resists stock ... the mistakes made by humans. Ms Nerea Goikoetxea, a researcher ... the population dynamics of the northern European hake population, observing ...
Cached Biology News:Learning secrets of world's most common organic compound driving research for biofuels 2Hake population has withstood overfishing, thanks to the warming of the sea 2Hake population has withstood overfishing, thanks to the warming of the sea 3
(Date:12/17/2014)... Bellingham, Washington, USA (PRWEB) December 16, 2014 ... Kirstin Baum, manager at Philipps- Universität Marburg’s Department ... optics and photonics, in the newly released ... 2015-2016. “And never be too shy to ask ... STEM (science, technology, engineering, and mathematics) occupations ranging ...
(Date:12/17/2014)... IN (PRWEB) December 17, 2014 ... Laboratory Excellence following its most recent COLA inspection. ... by COLA, a national healthcare accreditation organization. Accreditation ... standards of quality in day-to-day operations, demonstrate continued ... pass a rigorous on-site laboratory survey. ...
(Date:12/17/2014)... CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... primary commercial focus on China , ... C meeting with the U.S. Food and Drug Administration ... February 2015.  During this meeting the Company will seek ...
(Date:12/15/2014)... 2014 Organovo Holdings, Inc. (NYSE MKT: ... delivering breakthrough 3D bioprinting technology,  today celebrated continued ... its exVive3D TM Human Liver Tissue.  The ... commercial release on November 18, has been recognized ... awards for innovation. Most recently, on ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3
... company developing what it believes to be a novel tool ... tax credits from the State of Wisconsin to ... instead has raised a total of $385,000 from a combination ... to CEO Larry Wells, state law prohibits the company from ...
... Wis. - Last week, the nation marked ... stem cell research. Those restrictions have unquestionably set back ... say. , ,When Congress passed legislation that would ... among families whose loved ones are suffering from a ...
... - After months of speculation, North Prairie Productions, ... selected a site for a biodiesel plant that will produce ... will begin construction on the $42 million facility next spring ... side, where it will relocate its Waterloo offices. , ...
Cached Biology Technology:NovaScan decides against tax credits 2Stem cell research holds the promise for tomorrow 2Stem cell research holds the promise for tomorrow 3Evansville site chosen for biodiesel plant 2