Navigation Links
CSHL scientists identify and repress breast cancer stem cells in mouse tissue
Date:12/17/2007

Cold Spring Harbor, NY By manipulating highly specific gene-regulating molecules called microRNAs, scientists at Cold Spring Harbor Laboratory (CSHL) report that they have succeeded in singling out and repressing stem-like cells in mouse breast tissue cells that are widely thought to give rise to cancer.

If certain forms of breast cancer do indeed have their origin in wayward stem cells, as we believe to be the case, then it is critical to find ways to selectively attack that tumor-initiating population, said Gregory Hannon, Ph.D., CSHL professor and Howard Hughes Medical Institute Investigator. Hannon also is head of a lab focusing on small-RNA research at CSHL and corresponding author of a paper reporting the new research, published in the latest issue of Genes and Development.

We have shown that a microRNA called let-7, whose expression has previously been associated with tumor suppression, can be delivered to a sample of breast-tissue cells, where it can help us to distinguish stem-like tumor-initiating cells from other, more fully developed cells in the sample. Even more exciting, we found that by expressing let-7 in the sample, we were able to attack and essentially eliminate, very specifically, just that subpopulation of potentially dangerous progenitor cells.

The study was done in collaboration with Senthil Muthuswamy Ph.D., an expert in breast cancer research who heads a CSHL lab focusing on understanding the changes in the biology of breast epithelial cells during the initiation and progression of cancer. Dr. Muthuswamy emphasized that a key ingredient that made this study successful is the use of a mouse breast-derived model cell system called COMMA-1D that not only includes differentiated cells but also stem-like progenitors, in varying stages of maturity, or differentiation.

Unexpected Impact of Conventional Chemotherapy

No therapies currently exist that target stem-like tumor-initiating cells,
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... The announcement comes as demand for fire vault ... Ireland,s foremost records management company, has secured ... impressive track record of clients within the first 12 months, ... sector in Dubai . As a result, ... a further eight staff members at its Irish headquarters. The ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... Researchers from the Intermountain Medical Center Heart Institute, ... the National Institutes of Health, have discovered a simple ... heart disease: by measuring their body mass index or ... study is part of a larger study called faCTor-64, ...
... line of defense against viruses, bacteria and parasites that might ... a systematic chain of molecular signaling launches to close the ... study led by researchers from the University of Pennsylvania,s School ... role of one of the players in the wound-healing process, ...
... first comprehensive multi-model-based assessment of so-called Durban Platform scenarios, ... the Potsdam Institute for Climate Impact Research (PIK) and ... Durban Platform is the current negotiation track at the ... climate agreement by 2015 to come into effect in ...
Cached Biology News:Body mass index may predict heart disease risk for type-2 diabetic patients new study finds 2Body mass index may predict heart disease risk for type-2 diabetic patients new study finds 3Penn Dental Medicine team identifies molecule critical to healing wounds 2Success of climate talks vital for 2°C target 2Success of climate talks vital for 2°C target 3
(Date:5/25/2015)...  PureTech, a science-driven healthcare company seeking to solve ... announced today that Dame Marjorie Scardino , Chairman ... has been appointed to PureTech,s Board of Directors in ... Board member Joi Ito , MIT Media Lab,s ... Shapiro , PureTech,s outgoing Chairman and co-founder, former Executive ...
(Date:5/25/2015)... (PRWEB) May 25, 2015 The ... Chloride Industry is a professional and in-depth study ... Hydrogen Chloride Market with a focus on ... hydrogen chloride market research are Linde Industrial Gas, ... Yuanhua Chemical, Shandong Xinlong Group, Longsheng Group, Juhua ...
(Date:5/22/2015)... -- Actavis plc (NYSE: ACT ) today confirmed that ... the Second Circuit has issued a ruling upholding a ... continue distribution of NAMENDA ® (memantine HCl) immediate-release ... "While we are disappointed by the Court,s ... our strong efforts to convey the significant benefits of ...
(Date:5/22/2015)... MA (PRWEB) May 22, 2015 ... the U.S. Department of Agriculture (USDA), Grain Inspection, ... five year contract to Charm Sciences to monitor ... Quantitative Test (water-based) and ROSA FAST Aflatoxin Quantitative ... Aflatoxin Quantitative Test uses Water Extraction Technology ...
Breaking Biology Technology:PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 2PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 3Global Hydrogen Chloride Industry 2015 Trends and Analysis Available in a New Report at DeepResearchReports.com 2Global Hydrogen Chloride Industry 2015 Trends and Analysis Available in a New Report at DeepResearchReports.com 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2
... ABC,s Dancing with the Stars champion Drew Lachey has teamed ... launch the first national online video contest to increase ... The contest invites people to ... that help them stay active and healthy., ...
... EXTON, Pa., May 6 BioTrends Research Group,Inc. ... comprehensive insight into the management of,renal anemia and ... and Dialysis. These reports provide information from 105 ... -- data were collected,through an online survey fielded ...
... May 6 MedImmune today announced that,it ... the company,s expanded product,pipeline in the United ... core scientific,research that underpins this development. Jacqueline ... development team leadership; Lorin,Roskos, Ph.D. has been ...
Cached Biology Technology:Dancing With the Stars' Drew Lachey and Novo Nordisk Launch Dancin' to Change Diabetes National Video Contest 2BioTrends Releases Two Publications - TreatmentTrends(TM): Nephrologists and TreatmentTrends(TM): Renal Dietitians - Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases Two Publications - TreatmentTrends(TM): Nephrologists and TreatmentTrends(TM): Renal Dietitians - Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3MedImmune Fortifies Strategic Scientific Portfolio Management and International Leadership With New Executive Appointments 2MedImmune Fortifies Strategic Scientific Portfolio Management and International Leadership With New Executive Appointments 3
... Large T antigen initiates replication ... replication in the presence of ... product can be used in ... Replication Kit cat. no. 8050. ...
NuParaffin Kit Application: Flow Cytometry Reactivity: Human...
Request Info...
...
Biology Products: