Navigation Links
CSHL scientists identify a mechanism that helps fruit flies lock-in memories
Date:3/28/2008

Synapses are the tiny gaps across which information crosses between nerve cells. Changes in the strength of synaptic connections, called plasticity, play a vital role in both memory formation and learning, and help determine how nerve signals propagate.

Assistant professor Josh Dubnau, Ph.D., leads a CSHL neuroscience lab that studies learning and memory in fruit flies, or Drosophila. His team had previously identified a group of fly genes needed for memory formation, including one called Pumilio. A similar gene is present in humans, so studying Pumilio in the fly brain could help researchers understand how memory works in the human brain.

A Fruitful Hypothesis

Prior work had shown that Pumilio acts with other genes to shape the developing fly embryo, by modifying how much of various proteins is made in different regions of a cell. Dr. Dubnau hypothesized that the gene acts similarly to affect memory formation.

To further explore this idea, Dr. Dubnau collaborated with CSHL Professors Michael Zhang, Ph.D., a computational biologist, and Adrian Krainer, Ph.D., an expert on gene expression. He posed a question to Dr. Zhang that called for sophisticated mathematical analysis: For 151 genes known to be active in synapses, which of the protein-precursors they produce were most likely to interact with Pum, the protein made by Pumilio? Back in the laboratory, Dr. Krainers team confirmed that Pum interacts with several of the protein-precursors identified by Dr. Zhangs team, including one arising from a gene called dlg1. A gene very similar to dlg1 acts in synapse formation in mammals.

Testing the Result in Living Flies

What about the fly? Dr. Dubnaus lab performed the final step. They genetically engineered flies that made especially large amounts of Pum protein in a brain region called the mushroom body where memory storage occurs. They then confirmed that, in such flies, the protein product of t
'/>"/>

Contact: Jim Bono
pubaff@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , 31 de julho de 2015 A ... www.icg-10.org ) será realizada pela BGI de 22-25 de outubro ... A conferência está celebrando seu 10 o. ... a ICG se tornou uma das reuniões mais influentes ... encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... OXFORD, Conn. , Jul. 31, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies ... technology by introducing a common, uniform way to manage ...
(Date:7/27/2015)... , July 27, 2015   Zynx ... and experience-based clinical improvement solutions, today announced that ... is now available on Android smartphones and tablets. ... and post-care organizations can use ZynxCarebook to securely ... patient,s condition, streamline care transitions to other care ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... (hESCs) hold great promise for benefiting degenerative diseases, and ... be grown in a manner compatible with clinical use ... need for immunosuppression. These were a few of a ... led by Evan Y. Snyder, M.D., Ph.D., and spearheaded ...
... to be one of the world’s greatest mass death of ... Aceh, Indonesia on 28 March 2005. , The recent survey ... and the Australian Research Council Centre of Excellence for Coral ... Pulau Simeulue and Pulau Banyak off Aceh, Indonesia, in March ...
... gene that optimizes their brain's thinking circuitry, yet also ... illness marked by impaired thinking, scientists at the National ... (NIMH) have discovered. The seeming paradox emerged from ... in the human gene for a brain master switch, ...
Cached Biology News:Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 2Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 3Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 4Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 5Massive coral death attributed to earthquake 2Common gene version optimizes thinking -- but with a possible downside 2
(Date:7/29/2015)... According to a new market research ... Forecasts (2015-2020), , published by Mordor Intelligence, the Global market ... end of 2020, with North America ... of the global market size. The Global market for Stem ... during the period of (2015-2020).      (Logo: http://photos.prnewswire.com/prnh/20150428/740799) ...
(Date:7/29/2015)... Ala., July 29, 2015  HealthSouth ... nation,s largest providers of post-acute healthcare services, offering ... its results of operations for the second quarter ... quarter was characterized by strong volume growth in ... Adjusted EBITDA," said Jay Grinney, President and Chief ...
(Date:7/29/2015)... ... July 29, 2015 , ... Brady ... GHS Label Guide . To align chemical container labeling with OSHA’s updated ... explanations of label components, an example of an accurate label, and pictogram uses ...
(Date:7/29/2015)... -- Indivior PLC (LON: INDV) today announced that the New ... and received Priority Review by the U.S. Food and ... This naloxone nasal spray comes as a pre-filled device ... the nasal mucosa. 1 The device has been ... better equipped to help an opioid overdose victim. ...
Breaking Biology Technology:Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25HealthSouth Reports Results for Second Quarter 2015 26HealthSouth Reports Results for Second Quarter 2015 27HealthSouth Reports Results for Second Quarter 2015 28HealthSouth Reports Results for Second Quarter 2015 29HealthSouth Reports Results for Second Quarter 2015 30HealthSouth Reports Results for Second Quarter 2015 31HealthSouth Reports Results for Second Quarter 2015 32HealthSouth Reports Results for Second Quarter 2015 33HealthSouth Reports Results for Second Quarter 2015 34
... , , , , ... based,technology of Cellonis Biotechnologies, Beijing, a Chinese research/medical,team may eliminate ... old Norwegian,patient in a hospital in Beijing. The treatment shows ... as well as cancer daughter,cells. The amazing outcome of this ...
... ... technologies, including the new C35 Atex, at the American Association of Pharmaceutical Scientists’ Annual ... ... American Association of Pharmaceutical Scientists’ Annual Meeting, AAPS 2010 , in New Orleans, LA ...
... may inadequately stimulate a patient,s heart while undergoing a ... pulses mixing with the electronic pulses from the pacemaker. ... patient undergoing the MRI scan, according to research published ... Online . MRI is an imaging technique that ...
Cached Biology Technology:For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 2For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 3For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 4Particle Size Distribution Technologies at American Association of Pharmaceutical Scientists (AAPS) Annual Meeting 2010 2FDA researchers identify new MRI safety risk for patients with pacemakers 2
Anti-Conjugated Quinaldic Acid...
... effectively in tubes and 96 well plates. microCLEAN ... one and a half spin DNA cleanup reagent. ... concentrate any type of double stranded DNA, efficiently ... dNTPs (labelled or unlabelled). It is therefore ideally ...
... Super Sensitive MultiLink IHC Detection ... secondary antibodies, labeled with multiple ... the bound primary antibody, and ... Streptavidin-Enzyme conjugate. This kit is ...
... is available in a ready-to-use format. ... for dewaxing paraffin-embedded tissue sections prior ... or other analytical methods. The conventional ... dipping the slides in a series ...
Biology Products: