Navigation Links
CSHL scientists discover a new way in which epigenetic information is inherited
Date:11/27/2008

Hereditary information flows from parents to offspring not just through DNA but also through the millions of proteins and other molecules that cling to it. These modifications of DNA, known as "epigenetic marks," act both as a switch and a dial they can determine which genes should be turned on or off, and how much message an "on" gene should produce.

One way in which epigenetic information is known to be passed from parent to offspring is through the pattern of chemical "caps" added onto certain "letters" of the DNA sequence, ensuring the sequence is "silenced." How these DNA capping patterns, which are inherited, are precisely set is not yet known. But in some cases, enzymes that add these caps are guided to DNA by small RNA molecules. These guides themselves do not carry hereditary information, but they do mark the spots where DNA is to be modified.

A team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Gregory J. Hannon, Ph.D., has now discovered that a class of small RNAs does carry epigenetic information and in fact passes on the trait of fertility from mother to offspring in fruit flies.

A new mechanism of inheritance

In a paper to be published on Nov 27th in Science, the CSHL team reports that maternal small RNAs called Piwi-interacting RNAs (piRNAs) that are deposited into fruit fly embryos "silence" DNA sequences that induce sterility, thus ensuring the fertility of the progeny. "This is a whole new way in which heredity can be transmitted," says Professor Hannon, who is a pioneer in small RNA research. "With this finding we've effectively doubled the number of mechanisms by which epigenetic information is known to be inherited."

The piRNAs are found only in cells of sex organs and partner up with proteins called Piwi to suppress the activity of mobile DNA sequences called transposons. Discovered half a century ago by CSHL scientist and Nobel laureate Barbara McClint
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Caltech scientists develop barcode chip for cheap, fast blood tests
2. UNC scientists teach enzyme to make synthetic heparin in more varieties
3. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
4. Scientists shed light on evolution of gene regulation
5. Scientists build roach motel for nasty bugs of the bacterial variety
6. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
7. Scientists present moving theory behind bacterial decision-making
8. Penn scientists discover cells reorganize shape to fit the situation
9. Scientists discover 21st century plague
10. Bipolar disorder genes, pathways identified by Indiana University neuroscientists
11. Scripps research scientists identify blood component that turns bacteria virulent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... the 29th Annual International Papillomavirus Conference shows that ... combats three types of human papillomavirus, including the ... cancer. , When tested in several cultured human ... HPV-18 and HPV-11 cells, according to Louise T. ... the findings at the Seattle conference. The National ...
(Date:8/22/2014)... can probably remember the after-effects, including pain, swelling or ... back against the injury. When tissue in the body ... tissue regeneration. An inflammatory response acts as a protective ... to heal after injuries such as wounds and burns. ... situations in which foreign material is introduced, for example ...
(Date:8/22/2014)... tea polyphenols are strong antioxidants and can ... spinal cord neurons against oxidative stress? Jianbo ... Hospital of Liaoning Medical University, China discovered ... stress and inhibit neuronal apoptosis, indicating green ... spinal cord neurons under oxidative stress. The ...
Breaking Biology News(10 mins):Tissue regeneration using anti-inflammatory nanomolecules 2
... have won national awards for their research on the ... northern spotted owl. Martin Raphael and Eric Forsman, research ... Station, were named recipients of the Wings Across the ... the station,s Olympia, Wash., lab and Forsman at the ...
... barrier (BBB) remains a major obstacle to the successful ... disorders, reports Genetic Engineering and Biotechnology News ... approaches to preserve the ability of the BBB to ... and to permit the passage of effective medicines for ...
... plant pollen grains, sperm cells, which carry the genetic ... within larger "companion" cells that are called pollen vegetative ... nourishment, and push them towards their targets during fertilization. ... Spring Harbor Laboratory (CSHL) led by Professor Robert Martienssen, ...
Cached Biology News:Federal scientists recognized for contributions to knowledge of bird ecology and habitat 2GEN reports on strategies to overcome blood-brain barrier 2CSHL scientists discover how 'companion' cells to sperm protect them from genetic damage 2CSHL scientists discover how 'companion' cells to sperm protect them from genetic damage 3
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources ... Brazil and Mexico ... uptake of several newly approved agents, the anticipated ... indication and the launch of emerging biologics will ... In particular, the emerging IL-5 inhibitors will introduce ...
(Date:8/21/2014)... Cord Blood Corporation (NYSE: CO ) (the ... for the first quarter of fiscal year 2015 on ... US.  The Company will host a ... 29, 2014 to discuss its financial performance and give ... by a question and answer session.  Interested parties may ...
(Date:8/21/2014)... 21, 2014 Ontotext S4 , ... Ontotext . Now the same enterprise hardened ... structured and unstructured data is available to start-ups and ... enterprise technology. Organizations that do not have resources to ... can use S4 since there is no need for ...
(Date:8/21/2014)... August 21, 2014 On Wednesday of last ... to use Redox Signaling molecules, became available for purchase in ... , "The way that RENU 28 works is, if you ... down of the rate of cellular renewal within your body. ... increasing of that rate of cellular renewal. What RENU 28 ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2
... 16, 2011 Genesis Biopharma, Inc. (OTC ... developing targeted cancer therapies, today announced it is expanding ... various cancers.  The Company will focus on establishing a ... new strategy will be discussed during a presentation today ...
... SAN DIEGO, March 15, 2011 PR Newswire, ... solutions, today announced the extension of their exclusive ... be the preferred provider of content distribution services ... science association. (Logo: http://photos.prnewswire.com/prnh/20000306/PRNLOGO) ...
... Biotechnology company ImmusanT, Inc. today announced it ... is advancing its strategy to develop an immunotherapeutic ... disease. The company completed the acquisition of a ... Ltd., based in Melbourne, Australia, and secured seed ...
Cached Biology Technology:Genesis Biopharma Announces Plans to Develop Active Immunotherapy Platform 2PR Newswire and BIOCOM Purchasing Group Announce Renewal of Exclusive Partnership 2PR Newswire and BIOCOM Purchasing Group Announce Renewal of Exclusive Partnership 3Start-Up ImmusanT Seeks to Restore Tolerance to Gluten in Celiac Disease with Immunotherapy 2Start-Up ImmusanT Seeks to Restore Tolerance to Gluten in Celiac Disease with Immunotherapy 3Start-Up ImmusanT Seeks to Restore Tolerance to Gluten in Celiac Disease with Immunotherapy 4
... The kit measures mitochondria intactness ... mitochondrial membrane potential. Features and Benefits: ... method for staining isolated mitochondria and ... Contains all the reagents required for ...
... dispensers save space and organize ... and other garb. They are ... for small parts used in ... acrylic. Many other sizes and ...
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... Microarrays designed for genome-wide microRNA ... flexible and powerful Paraflo microfluidic on-chip ... as part of our comprehensive microRNA ... Content The Mammals microRNA Microarray ...
Biology Products: