Navigation Links
CSHL researchers solve structure of human protein critical for silencing genes
Date:5/25/2012

Cold Spring Harbor, N.Y. In a study published in the journal Cell on May 24, Cold Spring Harbor Laboratory (CSHL) scientists describe the three-dimensional atomic structure of a human protein bound to a piece of RNA that "guides" the protein's ability to silence genes. The protein, Argonaute-2, is a key player in RNA interference (RNAi), a powerful cellular phenomenon that has important roles in diverse biological processes, including an organism's development.

"Detailed knowledge of the structure of human Argonaute-2 and the way it interacts with its RNA guides will greatly improve our understanding of its biological mechanism of action," says CSHL Professor and HHMI Investigator Leemor Joshua-Tor, Ph.D., the study's leader. "Such precise structural information of the human Argonaute bound to an important RNA guide could potentially aid both basic research to understand the function of genes and also advance the development of RNAi as a therapeutic strategy in clinical settings."

Upon the activation of a gene within a cell, the gene's DNA is copied into a messenger RNA (mRNA) "transcript." The instructions encoded within this transcript are then used as a blueprint by the cell's protein synthesis machinery to generate a working protein. The gene is "silenced" or prevented from giving rise to the protein, however, when an Argonaute-2 protein that is bound to a small piece of "guide" RNAeither a short-interfering RNA or a microRNAintercepts the mRNA molecule. The guide RNA, whose nucleotide sequence matches that of the target mRNA, acts as a homing device that helps the Argonaute-2 protein zero in on the mRNA target.

A few years ago, Joshua-Tor collaborated with CSHL Professor and HHMI Investigator Gregory Hannon, Ph.D., who is also a co-author in this study, to show that Argonaute proteins, which are made up of different domains or parts, act like a pair of molecular scissors that slice up target mRNAs, thus preventing
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers identify genetic markers to predict male fertility
2. University of Hawaii Cancer Center researchers create new anti-cancer drug
3. UCLA researchers develop way to strengthen proteins with polymers
4. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
5. Researchers aim to assemble the tree of life for all 2 million named species
6. Dartmouth researchers are learning how exercise affects the brain
7. Nottingham researchers lead worlds largest study into pre-eclampsia
8. Begin early: Researchers say water with meals may encourage wiser choices
9. Researchers look to relatives for clues in quest to develop sources of bioenergy
10. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
11. KIT researchers succeed in realizing a new material class
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CSHL researchers solve structure of human protein critical for silencing genes
(Date:10/30/2014)... is available in German . ... prompt our fellow humans to behave socially? This is ... in game theory. Previous studies assumed that it is ... scientists from the Max Planck Institute for Evolutionary Biology ... an influence on the cooperative behaviour of others. However, ...
(Date:10/30/2014)... , Oct. 29, 2014  Securus Technologies, ... justice technology solutions for public safety, investigation, ... has deployed exciting enhancements to its THREADS™ ... to provide actionable intelligence and focused leads ... to drive technological innovation through identifying and ...
(Date:10/29/2014)... Online registration is open for the ... Scientific Meeting. SIR 2015 is the one ... trainees and related health care professionals can ... image-guided science and technologies being presented, discussed ... community in minimally invasive, image-guided medicine, SIR ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
... Capitol Hill, experts discussed how federally funded university research ... hearing, "Fueling Local Economies: Research, Innovation and Jobs," was ... by Rep. Carolyn Maloney (D-NY). Expert witnesses focused ... Samuel Stanley, president of Stony Brook University; Zachary Shulman, ...
... will present seven societal awards to distinguished ecologists at ... Pittsburgh. The meeting, which has the theme "Global Warming: ... future," draws a critical combination of more than 3,000 ... and consequences of global warming and to discuss the ...
... years as an herbal remedy to prevent or treat colds, ... medicines in North America. However, in spite of its popularity, ... immune system are conflicting. Now researchers from ... investigating the possibility that Echinacea has other potentially more important ...
Cached Biology News:NY state the focus of Congressional hearing on how research and innovation fuel local economies 2NY state the focus of Congressional hearing on how research and innovation fuel local economies 3Ecological Society of America announces 2010 award recipients 2Ecological Society of America announces 2010 award recipients 3Ecological Society of America announces 2010 award recipients 4
(Date:10/30/2014)... 2014 The report “Fragrance Ingredients Market ... (Cosmetics & Toiletries, and Soaps & Detergents) & by ... defined and segmented the Fragrance Ingredients Market with analyses ... of value. The market has been segmented on the ... Asia-Pacific, Latin America, and Rest of the World (ROW); ...
(Date:10/30/2014)... October 30, 2014 2014 Deep ... Industry” is a professional and in-depth research report ... basic Naltrexone HCL information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:10/30/2014)... 2014 James Sherley says he has been ... stem cell technology since his days as a principal investigator ... the late 1990’s. Sherley founded the ASCTC as a ... all the intellectual property developed in Sherley’s research over the ... Institute of Technology (MIT), and more recently as a senior ...
(Date:10/30/2014)... Ras Al Khaimah, UAE (PRWEB) October 30, 2014 ... the appointment of Dr. James A. Manganello, Chairman of the ... (NSCEC) of The Bahamas. The appointment was made by ... The Bahamas on September 24th, 2014. , More ... Cell Therapy and Research Bill , Prime Minister Perry Christie ...
Breaking Biology Technology:Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
... London, July 20 There has been a recent upsurge ... space. While the economic downturn and related credit crunch has had ... which has including four mega M&As in the first half of ... ) , , "The real intention ...
... , ... has added to its portfolio of topical hormonal modulators with the acquisition of a ... systemic activity and will be developed for skin and hair disorders associated with increased ... ...
... , SAN FRANCISCO, July 17 VIA ... focused on the development of compounds for the treatment of ... Staff Determination letter, dated July 15, 2009, from the NASDAQ ... with the minimum $2,500,000 stockholders, equity requirement for continued listing, ...
Cached Biology Technology:Big Pharma to Big Biopharma: Frost & Sullivan Examines the Latest M&A Trends and Opportunities 2Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent, Safe Topical Anti-Androgens 2Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent, Safe Topical Anti-Androgens 3VIA Pharmaceuticals Receives Anticipated Notice From NASDAQ 2VIA Pharmaceuticals Receives Anticipated Notice From NASDAQ 3VIA Pharmaceuticals Receives Anticipated Notice From NASDAQ 4
Mol wt: monoisotopic mol wt1,045.5423 Da by calculation...
Bis-Acrylamide (bis) is a monomer used as a crosslinker with acrylamide to form polyacrylamide electrophoretic gels. This 2% bis solution is supplied as 500 ml....
Anti-human VEGFR-2/KDR (Protein-A Purified) Polyclonal Antibody...
Mouse monoclonal antibody to Lats2....
Biology Products: