Navigation Links
CSHL researchers solve structure of human protein critical for silencing genes
Date:5/25/2012

Cold Spring Harbor, N.Y. In a study published in the journal Cell on May 24, Cold Spring Harbor Laboratory (CSHL) scientists describe the three-dimensional atomic structure of a human protein bound to a piece of RNA that "guides" the protein's ability to silence genes. The protein, Argonaute-2, is a key player in RNA interference (RNAi), a powerful cellular phenomenon that has important roles in diverse biological processes, including an organism's development.

"Detailed knowledge of the structure of human Argonaute-2 and the way it interacts with its RNA guides will greatly improve our understanding of its biological mechanism of action," says CSHL Professor and HHMI Investigator Leemor Joshua-Tor, Ph.D., the study's leader. "Such precise structural information of the human Argonaute bound to an important RNA guide could potentially aid both basic research to understand the function of genes and also advance the development of RNAi as a therapeutic strategy in clinical settings."

Upon the activation of a gene within a cell, the gene's DNA is copied into a messenger RNA (mRNA) "transcript." The instructions encoded within this transcript are then used as a blueprint by the cell's protein synthesis machinery to generate a working protein. The gene is "silenced" or prevented from giving rise to the protein, however, when an Argonaute-2 protein that is bound to a small piece of "guide" RNAeither a short-interfering RNA or a microRNAintercepts the mRNA molecule. The guide RNA, whose nucleotide sequence matches that of the target mRNA, acts as a homing device that helps the Argonaute-2 protein zero in on the mRNA target.

A few years ago, Joshua-Tor collaborated with CSHL Professor and HHMI Investigator Gregory Hannon, Ph.D., who is also a co-author in this study, to show that Argonaute proteins, which are made up of different domains or parts, act like a pair of molecular scissors that slice up target mRNAs, thus preventing
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers identify genetic markers to predict male fertility
2. University of Hawaii Cancer Center researchers create new anti-cancer drug
3. UCLA researchers develop way to strengthen proteins with polymers
4. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
5. Researchers aim to assemble the tree of life for all 2 million named species
6. Dartmouth researchers are learning how exercise affects the brain
7. Nottingham researchers lead worlds largest study into pre-eclampsia
8. Begin early: Researchers say water with meals may encourage wiser choices
9. Researchers look to relatives for clues in quest to develop sources of bioenergy
10. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
11. KIT researchers succeed in realizing a new material class
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CSHL researchers solve structure of human protein critical for silencing genes
(Date:5/29/2015)... , May 28, 2015 Research ... addition of the "Facial Recognition Market by ... - Global Forecast to 2020" report to ... have seen facial recognition technology become more efficient ... to gain traction and investment from the commercial ...
(Date:5/28/2015)... 28, 2015 Industry analyst firm n-tech ... report titled "Markets for Self-Healing Materials: 2015-2022." According to ... and vascular systems, biomaterials, relevant shape memory materials ... $2.7 billion by 2020. The report ... of smart materials. Other recent n-tech reports have included ...
(Date:5/27/2015)... 27, 2015   Codonics (codonics.com), ... and image documentation solutions and Omnicell ... automation solutions, is pleased to announce their ... Safe Label System® (SLS), an award-winning FDA ... the Omnicell Anesthesia Workstation, helps prevent medication ...
Breaking Biology News(10 mins):Global advanced Facial Recognition Market Expected to Grow From $2.77 Billion in 2015 to $6.19 Billion in 2020, at an Estimated CAGR of 17.4% 2The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 2The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 3Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4
... MADISON, WI, SEPTEMBER 21, 2009 A new ... , documents the history, science, and applications of tall ... increasing role in protecting soil and water and enhancing ... from around the world who address an array of ...
... after plucking the fossilized tooth of a new human ... team of scientists today (Thursday, Oct. 1) announced their ... Ardipithecus ramidus , which they say revolutionizes our understanding ... female skeleton, nicknamed Ardi, is 4.4 million years old, ...
... African bees were accidentally released in Brazil in 1957. ... at the Smithsonian Tropical Research Institute, began a 17-year ... to native bees than changes in the weather and ... , Scientists feared that dangerous swarms of Africanized bees ...
Cached Biology News:Tall fescue's future in agriculture 2Ardi displaces Lucy as oldest hominid skeleton 2Ardi displaces Lucy as oldest hominid skeleton 3Ardi displaces Lucy as oldest hominid skeleton 4Ardi displaces Lucy as oldest hominid skeleton 5Killer bees may increase food supplies for native bees 2
(Date:5/28/2015)... Research and Markets( http://www.researchandmarkets.com/research/6cg3zw/cell_therapy ) has ... "Cell Therapy - Technologies, Markets and Companies" ... describes and evaluates cell therapy technologies and methods, ... role in the practice of medicine. Hematopoietic stem ... marrow transplants. Role of cells in drug discovery ...
(Date:5/28/2015)... IN (PRWEB) May 28, 2015 The Academy ... National Model Aviation Day on August 15, 2015. National Model ... aviation nation-wide and to introduce model flying to the general ... 2,350 chartered clubs to participate in the celebration by hosting ... registered to host National Model Aviation Day events. View ...
(Date:5/28/2015)... , May 28, 2015 Natera, ... announced a study published in Ultrasound in ... single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) can ... trimester. A study based upon ... molar pregnancies occur in about 1 in 1,000 ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 BioNorth ... serving and representing the life sciences industry in ... of Directors meeting at The Foundry in Dallas ... the organization brought together a broad spectrum of ... underscored the organization's early successes in partnering with ...
Breaking Biology Technology:Global Cell Therapy Market 2015-2020 - Technologies, Markets and Companies 2Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3
... , ... integral to the SPEX FLUOROMAX -P or as an accessory ... information on various systems of chemical and biochemical interest, by revealing data ... <P,>This Application Note describes an example, using the SPEX ...
... , ... DataMax is the software used to display data from all SPEX ... a contour map. A contour map displays multifiles or 3-D data, and ... meteorological plot of barometric pressures. X values are plotted on the horizontal ...
... Introduction , ... 1 O 2 , is of considerable interest in environmental applications, ... been directed towards understanding the biological effects of 1 O 2 ... a dye, oxygen, and light. <P,>An understanding of the mechanisms that produce ...
Cached Biology Technology:Phosphorescence lifetime measured using the SPEX phosphorimeter 2Obtaining a contour map from multifiles or 3D data in DataMax 2Obtaining a contour map from multifiles or 3D data in DataMax 3Singlet Oxygen measurement 2
Mouse monoclonal antibody raised against a partial recombinant WDR5. NCBI Entrez Gene ID = WDR5...
... is a sample preparation kit for reduction ... of detergents, phenolic compounds, salts, and most ... samples. The kit procedure involves a TCA-like ... or cells, plant leaves, E. coli, and ...
... The ReadyPrep 2-D starter kit is intended ... and ReadyStrip IPG strips. The kit includes a ... and transfer to second-dimension gels six 17 cm, ... IPG strips (ReadyStrip IPG strips and precast SDS-PAGE ...
... Anti-Mi-2 Immunogen : ... acid residues 474-970 of human ... 7.4, 0.105M NaCl, 0.035% sodium ... Assurance: routinely evaluated by immunoblot ...
Biology Products: