Navigation Links
CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments
Date:4/9/2009

tromeres are crucial for genomic integrity, aberrant heterochromatin formation can result in genetic anomalies and diseases such as cancer.

Heterochromatin depends on the density of chemical "marks" that are added to histones at specific locations on their tail ends. These marks consist of methyl groups that get attached to the tail of one of the histones, histone H3, at a specific spot the ninth residue, which happens to be the amino acid lysine (K). This mark is therefore called H3K9me.

In fission yeast, a model system used for studying heterochromatin mechanisms because of its comparative simplicity, the precise pattern of methylation depends on a process called RNA interference, or RNAi. It involves a host of players: the enzyme that copies DNA into RNA, which is diced into short segments called short interfering RNAs, or siRNAs; a part of the RNAi machinery known as the RITS complex; and various enzymes that are able to alter the configuration of chromatin.

A debate over recruitment

"In trying to understand the interplay between each of these components," explains Joshua-Tor, "there has been a longstanding debate over how the RITS complex initially gets recruited to the regions at the centromere that are destined to become heterochromatin."

At first, scientists thought that the siRNA molecules acted as guides to recruit RITS. After latching on to the chromatin, RITS was in turn thought to recruit the other components: the enzyme that adds the methyl marks; and the protein Chp1, which acts as a molecular "velcro" to keep the RITS complex firmly attached to the methyl-decorated chromatin.

The importance of binding strength

The CSHL team in collaboration with the team of Janet Partridge at St. Jude's Children's Research Hospital, Memphis, has now found that siRNAs cannot do the job of heterochromatin assembly by themselves. Rather, the siRNA-guided interaction relies on the strength with
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Stem cell therapy makes cloudy corneas clear, according to Pitt researchers
2. Biomedical researchers invited to design experiments for the International Space Station
3. Caltech researchers train computers to analyze fruit-fly behavior
4. International climate change researchers meet, review latest findings
5. Einstein researchers devise a fast and sensitive way to detect ricin
6. NC State researchers find soy may aid in treating canine cancers
7. Queens researchers shine light on compact fluorescent bulb problems
8. Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic
9. Researchers discover primer to plant defense system
10. MDC researchers prevent virus induced myocarditis
11. Researchers examine bacterial rice diseases, search for genetic solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... DALLAS , May 21, 2015 ... report, "Thermal Imaging Market by Solutions (Hardware, Software, Services), ... Veterinary, Automotive & others), by End-Users (Military & ... published by MarketsandMarkets, Thermal Imaging Market is expected ... $9998.9 Million by 2020, at a Compound Annual ...
(Date:5/19/2015)... 19, 2015  Technology is rapidly advancing, outpacing enterprises, ... the cloud. Passwords and their management are soon to ... standards-based specifications such as those developed by the FIDO ... passwords presents for BYOD, COPE, IoT, and mobile payments, ... protocol. In response to the call ...
(Date:5/11/2015)... JOSE, Calif. , May 11, 2015 /PRNewswire/ ... developer of human interface solutions, today announced the ... Vice President and Chief Financial Officer, reporting to ... Ali replaces Synaptics, current Chief Financial Officer, ... December 2014. Mr. Ali brings ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... National biobanks play a vital role in modern health research ... data, but they are expensive to run. Can we make ... borders on a larger scale? This is the theme of ... How can we maximize the value and use of ...
... the Johns Hopkins Bloomberg School of Public Health have ... triggers an immune response in multiple mosquito species capable ... parasite that causes malaria in humans. By silencing ... the development of the malaria-causing parasite in Anopheles ...
... Software, a company with an outstanding track record ... high throughput technologies, announced today that it was ... "Identification and assignment of functionally corresponding regulatory sequences ... European Patent Office. The Patent relates to ...
Cached Biology News:Harmonizing biobank research: An achievable world-wide goal 2Malaria immunity trigger found for multiple mosquito species 2Genomatix gets patent for comparative genomics method 2
(Date:6/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/6wjpd6/bioburden_testing ) has announced ... Product , Test, Application & End User - Forecast ... The bioburden testing market is expected to reach $565.6 ... at a CAGR of 9.8% from 2014 to 2019 ... testing market is segmented into consumables and instruments. The ...
(Date:6/2/2015)... June 2, 2015 Meet ARGUS, ... Scanner. Scan & Read People. Analyze emotions and predict ... Concepts, including the very first Responsive-RPG: "The Eye: Genesis". ... , , , , https://www.youtube.com/watch?v=B1ZEtAZ2Yf8 ... truly affect your inner feelings - and those of ...
(Date:6/2/2015)... Pa. , June 2, 2015   ... be attending the BIO Exhibition 2015 in ... Exhibition, the world,s largest biotechnology gathering, allows influential ... high-level executives, where they can evaluate emerging technologies ... significant eClinical expertise in the design, implementation and ...
(Date:6/2/2015)... 2015   Sigma-Aldrich Corporation (NASDAQ: SIAL ... announced today it has entered into an agreement ... engineered human neural differentiated cells and accompanying culture ... diseases. These new products, in combination with Sigma-Aldrich,s ... for the study of central nervous system (CNS) ...
Breaking Biology Technology:Bioburden Testing Market 2015 - Global Forecasts to 2019 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 3YPrime at BIO Exhibition in Philadelphia and DIA in Washington DC during the month of June 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 3
... 19, 2012 Separate Study ... Two studies presented at the International ... disease has across Europe. One highlights the financial cost ... highlights the high mortality rates associated with cirrhosis. ...
... selective hearing works how people can tune in to ... is solved this week in the journal Nature ... Francisco (UCSF). Psychologists have known for decades about the ... Men era in which it was coined. It is the ...
... More than half-a-century ago, the Dutch theoretical physicist Hendrik ... in a vacuum would attract. The mysterious force arises ... out of existence, as described by quantum theory. Now ... in Japan, has predicted that in certain circumstances a ...
Cached Biology Technology:Chronic Hepatic Diseases Generate High Costs to Europe 2Chronic Hepatic Diseases Generate High Costs to Europe 3Chronic Hepatic Diseases Generate High Costs to Europe 4How selective hearing works in the brain 2How selective hearing works in the brain 3
... 15(S)-15-methyl PGF2α is a metabolically ... is a potent uterine stimulant ... administered intramuscularly to induce labor. ... serum progesterone concentrations when given ...
... S-X media are neutral, porous ... exclusion chromatography of lipophilic polymers ... organic eluents. The beads are ... carbon tetrachloride, dimethylformamide, ketones, aromatics, ...
... Epitope: A BALB/c mouse was ... Recommended Storage: Store vial at -20 C ... at -20 C or below for extended storage. ... Centrifuge product if not completely clear after standing ...
Mouse monoclonal [HYB 232-02] to Protein S ( Abpromise for all tested applications). entrezGeneID: 5627 SwissProtID: P07225...
Biology Products: