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CSHL neuroscientists show 'jumping genes' may contribute to aging-related brain defects
Date:4/8/2013

" href="http://www.cshl.edu/Article-Dubnau/storm-of-awakened-transposons-may-cause-brain-cell-pathologies-in-als-other-neurodegenerative-ill">http://www.cshl.edu/Article-Dubnau/storm-of-awakened-transposons-may-cause-brain-cell-pathologies-in-als-other-neurodegenerative-ill].

Taken together with the results in his team's new paper, Dubnau proposes that a "transposon storm" may be responsible for age-related neurodegeneration as well as the pathology seen in some neurodegenerative disorders.

However, his studies so far don't address whether transposons are the cause or an effect of aging-related brain defects. "The next step will be to activate transposons by genetically manipulating fruit flies and ask whether they are a direct cause of neurodegeneration," Dubnau says.


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Contact: Edward Brydon
ebrydon@cshl.edu
917-476-6633
Cold Spring Harbor Laboratory
Source:Eurekalert

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