Navigation Links
CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die
Date:4/10/2009

t kinds of expertise coming together" in what he describes as "a lovely moment" of synthesis and discovery. An important collaborator in the work, C. David Allis, Ph.D., of the Rockefeller University, had recently published a paper in Nature describing a critical component of the DNA damage-repair signaling cascade. The Tonks-Allis collaboration, along with contributions from Seung Jun Kim, Ph.D., a protein crystallographer from the Korea Research Institute of Bioscience and Biotechnology, led to the assembly of a puzzle from pieces whose precise relation was not previously understood.

The parts of the puzzle include a protein called H2A.X, one of a species of proteins called histones that form structures around which DNA is "spooled" for dense packing in the cell nucleus. "David Allis showed us that this particular histone, which is found at those critical decision points called gamma-H2A.X foci, has phosphate groups added to its structure at particular points at the end of the protein. David demonstrated that another kind of protein --a kinase called WSTF -- attaches phosphate to critical site, a tyrosine residue, at the extreme end of the protein," Tonks explains..

"I was interested in the fact that when there is damage to double-stranded DNA catastrophic damage, such as when the strand breaks in two the phosphate molecule placed at the decision point by WSTF has to be removed in order for the cell to send out signals for DNA-repair enzymes to come to the scene."

The removal of phosphate groups from proteins is accomplished by a family of enzymes called phosphatases the focus of much research in Tonks' CSHL laboratory. Tonks is well known for having characterized the first of what has come to be understood as a large superfamily of protein tyrosine phosphatases, or PTPs enzymes that specifically remove phosphate molecules from amino acid residues called tyrosines. This function is critical in regulating cellular signaling in
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. ISU researcher identifies protein that concentrates carbon dioxide in algae
2. Team identifies a molecular switch linking infectious disease and depression
3. UK researcher identifies just 8 patterns as the cause of all humor
4. Scripps research team identifies key molecules that inhibit viral production
5. Online collaboration identifies bacteria
6. International study identifies gene variants associated with early heart attack
7. MU researcher identifies possible genetic causes of borderline personality disorder
8. Stowers Institutes Baumann Lab identifies key step in maturation pathway of telomerase
9. Study identifies genetic variants giving rise to differences in metabolism
10. St. Jude identifies genomic causes of a certain type of leukemia relapse
11. LSUHSC research identifies key contributor to Alzheimers disease process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... climatic shifts over the last 120,000 years may ... team of researchers led by City College of ... new biodiversity metric called "phylogeographic endemism." , It ... within species is restricted in geographical space. , ... 14 other researchers from institutions in Brazil, Australia ...
(Date:8/29/2014)... prolific bloomer Emiliania huxleyi , can grow without ... contradicts the common view that E. huxleyi ... of thiamine in the ocean to survive. , "It,s ... says CIFAR Senior Fellow Alexandra Worden , co-author ... fellows John Archibald (Dalhousie University), Adrin ...
(Date:8/28/2014)... app called TX Invasives is now available from the ... Texas at Austin for identifying harmful non-native plant, insect ... in the United States cause about $137 billion in ... crops, clog waterways, kill native plants and more. , ... for reporting where invasive species occur, we,re more likely ...
Breaking Biology News(10 mins):CCNY team defines new biodiversity metric 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... their mate with the help of smell. They prefer a ... immune system. This has been shown in a new study ... collaboration. Humans and many animals can choose a suitable ... can give the offspring an efficient immune system. This is ...
... After 16 years of planning the countdown is on for one ... a 12-man team of British scientists, engineers and support staff will ... into the heart of the frozen continent to collect samples of ... of ice. Their quest is to reveal vital secrets about ...
... studies focused on life science, drug discovery and ... The Indiana-based manufacturer of radiation detection technologies is ... of Energy,s Oak Ridge National Laboratory toward the ... researchers to study a wider variety of crystalline ...
Cached Biology News:British team set to embark on ambitious Antarctic mission to penetrate and sample ancient buried lake 2British team set to embark on ambitious Antarctic mission to penetrate and sample ancient buried lake 3ORNL's newly licensed neutron detector will advance human disease research 2
(Date:8/29/2014)... Three Lawrence Livermore researchers have ... Production R&D Award for their research in ... sunlight. , Shared with collaborators from the National ... Nevada, Las Vegas (UNLV), the award recognizes the ... solar-hydrogen production and corrosion processes. , These models ...
(Date:8/29/2014)... TX (PRWEB) August 29, 2014 ... ISO 13485:2003 certified, GAMP® 5 compliant imaging core ... an international Phase II clinical trial to assess ... , Throughout this trial, Intrinsic Imaging will provide ... limited to, protocol and charter development, site qualification, ...
(Date:8/28/2014)... 2014 Best Sanitizers, Inc., the first ... hand sanitizer, asks food processors and food handling professionals ... sanitizer they’re currently using to Best Sanitizers’ Alpet® ... critical to fighting cross-contamination and the spread of pathogens ... there are key criteria that make a hand sanitizer ...
(Date:8/28/2014)... important devices in spintronics, an electronic which is ... but also on their spin and the spin-related ... into magnetic signals and vice versa. Recently, the ... Institute of Physics at Johannes Gutenberg University Mainz ... and Japan, has for the first time realised ...
Breaking Biology Technology:Livermore Team Awarded for Hydrogen Production Research 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3A new, tunable device for spintronics 2A new, tunable device for spintronics 3
... Australia, Dec. 17 Phosphagenics,Limited ("Phosphagenics") (ASX: POH, ... its Phase 1 clinical trial that showed its,delivery ... skin without causing disruption or irritation of any ... be the first company to,commercialize a sustained release ...
... MOUNTAINSIDE, N.J., Dec. 17 National Stem,Cell Holding, ... company,information, financial information, quotations and press releases are,posted ... Sheets., OTCIQ is a secure, web-based portal ... to facilitate communication with the,marketplace, promote transparency, mitigate ...
... Will Enhance Quality and Speed Image Transfer at Lower ... Cost While Ensuring 21 CFR Part 11 Compliance, ... network, today announced it has been selected by,Southwest Oncology Group ... groups in the United States, to provide a,secure, 21 CFR ...
Cached Biology Technology:Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 2Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 3National Stem Cell Holding, Inc. Posts Company and Financial Information on the OTCIQ and Has Retained New CFO and Counsel to File Registration Statement With SEC 2AG Mednet to Provide Image Network for Southwest Oncology Group 2
MAb to Desmoplakin I & II Desmoplakin I & II...
...
BD Primaria 35 mm Cell Culture Dish with Easy-Grip design, surface-modified polystyrene for enhanced cell culture. (20/sp, 200/ca) Packaging: 20 / sleeve, 500 / case ...
...
Biology Products: