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CRISPR system can promote antibiotic resistance
Date:7/14/2014

r of medicine (infectious diseases) at Emory University School of Medicine and Yerkes National Primate Research Center. "That increased permeability also seems to make them more likely to set off alarms when they are infecting mammalian cells."

Graduate student Timothy Sampson, working with Weiss, found that Cas9 mutant bacteria may be more likely to leak bits of their DNA, a trigger for immune cells to get excited. This is a large reason why Cas9 is necessary for F. novicida to evade the mammalian immune system, a finding published in a 2013 Nature paper.

The regulatory role for Cas9 does not appear to be restricted to F. novicida; Weiss's team found that a Cas9 mutant in Campylobacter jejuni, a bacterium that is a common cause of human gastroenteritis, also has increased permeability and impaired antibiotic resistance.

The findings add to recent discoveries where Cas9 has been found to be involved in virulence the ability to cause disease in a living animal or human -- in various pathogenic bacteria such as Campylobacter and Neisseria meningitides.


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Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences
Source:Eurekalert

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