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CNIO team presents a new strategy to personalise cancer therapies
Date:4/29/2014

conditions: if the drug works in the avatar, the likelihood of it also working in the patient is very high.

Therefore, the treatments that worked best in the avatar mice were the ones given to patients. The results showed clinical benefit, either the stabilisation of the disease or a partial clinical response, in up to 77% of patients.

"We have demonstrated that it is possible to apply our personalised cancer treatment strategy to the clinic", says Garralda, adding: "as we learn more about the genetic information obtained from cancer exome sequencing, future clinical trials will allow for the inclusion of patients with specific genetic alterations, and therefore a better access to cancer drugs."

FUTURE ASSAYS ON PANCREATIC CANCER

Currently, one the main objectives for the team is to study the efficiency of the procedures in a larger number of patients with advanced pancreatic cancer, thereby comparing them to standard treatments.

Pancreatic cancer often has a poor prognosis, with survival rates of less than 1 year. It is a complex and heterogeneous disease, meaning that the personalised study of the most relevant mutations in tumour growth (driver mutations) could be a promising strategy in the search for new treatments.


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Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

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