Navigation Links
CNIO study chosen as discovery of the year in regenerative medicine
Date:12/11/2013

The prestigious journal Nature Medicine has taken a look at the year and chosen one of the Spanish National Cancer Research Centre's (CNIO) studies as the most important in the stem cell category for its special December edition. The edition highlights eight categories, including, as well as stem cells, immunology, cardiovascular disease or neuroscience.

The study in question, led by Manuel Serrano, the director of CNIO's Molecular Oncology Programme, was published last September in the journal Nature with the title Reprogramming in vivo produces teratomas and iPSCs with totipotency features (https://www.cnio.es/es/news/docs/manuel-serrano-nature-11sep13-es.pdf).

The most important milestone achieved by the research was demostrating that cells from a variety of tissues, such as that of intestine, stomach, kidney or pancreas, can be turned into embryonic stem cells. To do so, CNIO researchers used the technique developed by the scientist Shinya Yamanaka (2012 Nobel Prize for Medicine) to obtain embryonic stem cells in vitro.

"Being able to apply this technique directly to tissues from living organisms was a big surprise, as it was thought in vivo conditions would not allow for this extent of cellular plasticity", says Serrano.

The journal Nature Medicine highlights that: "The significance of this work goes beyond the generation of a mouse with reprogrammable tissue", adding that "stem cells created in vivo reached a totipotent-like state and a plasticity that surpasses that of embryonic stem cells and other iPSCs made in a dish".

In this context, the cells obtained in Serrano's laboratory were even capable of forming pseudo-embryonic structures and extra-embryonic tissues such as the yolk sac.

The researchers emphasise that practical applications might yet be some way off, but admit it could change the direction of stem cell research and its applications for regenerative medicine and tissue engineering.

"The in vivo reprogramming achieved this year may bring researchers one step closer to protocols that can accomplish controlled tissue reprogramming", says the journal in its conclusion on CNIO's work.


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining ... Chicago. The result of a collaboration among several companies with expertise in toolholding, ...
Breaking Biology Technology: