Navigation Links
CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
Date:7/9/2014

tissues, such as the liver of kidney, were completely indifferent to the expression of NANOG", says Serrano. This reinforces the idea that NANOG selectively operates in stratified epithelia.

"Using genome-wide analysis, we demonstrate that this factor is able to specifically regulate cell proliferation in these tissues, and it does it by means of the AURKA protein that is involved in the control of cell division", says Serrano.

The authors of the work also show that NANOG is increased in patient-derived tumour samples from stratified epithelia. Furthermore, when they blocked the action of the gene using RNA interference, the cell proliferation index was reduced.

"This tells us that these cancerous cells depend on NANOG activity to maintain their high proliferation rate and oncological properties", says Serrano.

The study has benefitted from the participation of CNIO researchers Marcos Malumbres and Ignacio Prez de Castro, who are experts on protein AURKA and its role in the cell cycle. This work has been funded by the Ministry of Economy and Competitiveness, the European Union, the Community of Madrid, the Botn Foundation, the Ramn Areces Foundation, and the AXA Foundation.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
(Date:1/22/2015)... Jan. 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), ... crowdfunding campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz ... production capacity to meet customer demand. ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ) ... Wearable Technologies Market and Applications, Opportunities, Industry Analysis, ... 2014-2020" report to their offering. , ... can be worn on the user,s body and ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... The Netherlands: Ultra-fast freezing of ovarian tissue from women ... cancer treatment can lead to it being used in ... a researcher told the 25th annual conference of the ... 29 June). Dr. Sherman Silber, Director of the St. ...
... 58 km southeast of Shingu City, Japan--Deepsea Drilling Vessel ... Trough Seismogenic Zone off the Kii Peninsula of Japan. ... water depths of 2,054 meters. Following sea floor surveys, ... prevention (BOP) system into an upper section of the ...
... Amsterdam, The Netherlands: Dutch researchers have found the first evidence ... development and implantation, which was known to occur in mice ... human female embryos prior to implantation in the womb. ... of the European Society of Human Reproduction and Embryology in ...
Cached Biology News:Ovarian transplantation: New technique gives greatly improved results in this delicate operation 2First riser-drilling research operations undertaken 2Female human embryos adjust the balance of X chromosomes before implantation 2Female human embryos adjust the balance of X chromosomes before implantation 3Female human embryos adjust the balance of X chromosomes before implantation 4
(Date:1/22/2015)... (PRWEB) January 22, 2015 Protocol Networks ... The growing team of brand-neutral, independent consultants, Protocol Networks ... Rogers explained that over the years, his company has ... Moroso, Town of Plainfield, as well as others. With ...
(Date:1/22/2015)... Wilmington, DE (PRWEB) January 22, 2015 ... the Pistoia Alliance, which helps companies check the legal ... set to expand to China. , As their ... companies are globally adopting software solutions built as a ...
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... in critical areas, announced the closing of an underwritten public ... purchase up to an aggregate 3,500,000 shares of common stock, ... per warrant.  The warrants have a per share exercise price ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... Veridex, LLC announced today,that the technology used ... (CTCs) was ranked as the top medical innovation ... academic medical center. The,ranking is based on technologies ... next year., The prestigious annual recognition follows ...
... pioneer in scalable, high performance cell loading systems, ... with industry experts on the,challenges in developing cell-based ... to the industry and will be held by ... of the respected industry experts leading this live ...
... AMDL, Inc. (Amex:,ADL), a vertically integrated pharmaceutical ... today preliminary third quarter earnings and,revised 2008 guidance ... AMDL expects gross sales to be,approximately $12.4 million ... million. Gross profit is expected to be approximately,$4.9 ...
Cached Biology Technology:Cleveland Clinic Recognizes Circulating Tumor Cell Technology as Top Medical Innovation for 2009 2Cleveland Clinic Recognizes Circulating Tumor Cell Technology as Top Medical Innovation for 2009 3MaxCyte Hosts Live Discussion with Industry Experts on the Challenges in Developing Cell-Based Screening Assays for Drug Discovery 2AMDL Announces Preliminary Third Quarter Earnings; Revises 2008 Guidance 2AMDL Announces Preliminary Third Quarter Earnings; Revises 2008 Guidance 3
Acetate Plate Sealers 100/Box...
... proteomics demands the detection of very small ... the AXIMA-CFRplus with improved resolution (20,000) and ... increased confidence in protein identification. The AXIMA-CFRplus ... automated sample target handling and the ability ...
QCPN...
... Axima range, the AXIMA-CFR provides a ... sensitivity and mass range, and offers ... reflectron time-of-flight analysis. The unique patented ... of seamless PSD, providing efficient and ...
Biology Products: