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CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
Date:7/9/2014

tissues, such as the liver of kidney, were completely indifferent to the expression of NANOG", says Serrano. This reinforces the idea that NANOG selectively operates in stratified epithelia.

"Using genome-wide analysis, we demonstrate that this factor is able to specifically regulate cell proliferation in these tissues, and it does it by means of the AURKA protein that is involved in the control of cell division", says Serrano.

The authors of the work also show that NANOG is increased in patient-derived tumour samples from stratified epithelia. Furthermore, when they blocked the action of the gene using RNA interference, the cell proliferation index was reduced.

"This tells us that these cancerous cells depend on NANOG activity to maintain their high proliferation rate and oncological properties", says Serrano.

The study has benefitted from the participation of CNIO researchers Marcos Malumbres and Ignacio Prez de Castro, who are experts on protein AURKA and its role in the cell cycle. This work has been funded by the Ministry of Economy and Competitiveness, the European Union, the Community of Madrid, the Botn Foundation, the Ramn Areces Foundation, and the AXA Foundation.


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Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

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