Navigation Links
CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
Date:7/9/2014

Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epitheliathose that form part of the epidermis of the skin or cover the oesophagus or the vaginain adult organisms. According to the conclusions of the study, published in the journal Nature Communications, this factor could also play a role in the formation of tumours derived from stratified epithelia of the oesophagus and skin.

The pluripotency factor NANOG is active during just two days previous to the implantation of the embryo in the uterus (from day 5 to day 7 post-fertilization). At this critical period of development, NANOG contributes to giving embryonic stem cells the extraordinary capacity to make up all of the tissues that become the adult organism, an ability technically known as pluripotency.

Up until now, it was thought that the function of NANOG was limited to the above-mentioned developmental stage immediately prior to implantation. The CNIO study, led by Manuel Serrano and Daniela Piazzolla, however, shows that NANOG also plays a role in the adult organism.

After analysing the presence of NANOG in different mouse tissues by immunohistochemistry, the CNIO team demonstrated that, in addition to being present in embryonic tissue, this factor is also found in stratified epithelia such as the oesophagus, skin or vagina.

NANOG Is Linked to Tumours Derived From Stratified Epithelia

Furthermore, the researchers studied a line of mice that can be programmed to induce the NANOG factor over a limited period of time. As described in the article, when NANOG was increased in these mice, the epithelia showed an increase in cellular proliferation, hyperplasia, and an increase in the amount of DNA damage in the cells.

"Interestingly, the effects of NANOG were only observed in stratified epithelia, whereas other tissues, such as the liver of kidney, were completely indifferent to the expression of NANOG", says Serrano. This reinforces the idea that NANOG selectively operates in stratified epithelia.

"Using genome-wide analysis, we demonstrate that this factor is able to specifically regulate cell proliferation in these tissues, and it does it by means of the AURKA protein that is involved in the control of cell division", says Serrano.

The authors of the work also show that NANOG is increased in patient-derived tumour samples from stratified epithelia. Furthermore, when they blocked the action of the gene using RNA interference, the cell proliferation index was reduced.

"This tells us that these cancerous cells depend on NANOG activity to maintain their high proliferation rate and oncological properties", says Serrano.

The study has benefitted from the participation of CNIO researchers Marcos Malumbres and Ignacio Prez de Castro, who are experts on protein AURKA and its role in the cell cycle. This work has been funded by the Ministry of Economy and Competitiveness, the European Union, the Community of Madrid, the Botn Foundation, the Ramn Areces Foundation, and the AXA Foundation.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... April 28, 2016 , ... As ... recruiting top industry experts, and expanding its LATAM network and logistics capabilities. ... clients to manage their clinical trial projects. , The expansion will provide unmatched ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... screen mobile devices with fingerprint recognition for secure access, voice recognition for hands-free ... few ways consumers are interacting with biometrics technology today. But if they ...
(Date:4/27/2016)... ... 2016 , ... PathSensors, Inc., a leading environmental testing company, ... assist PathSensors in expanding the use of the company‚Äôs CANARY® technology in the ... for the detection of harmful pathogens, including a number of bacteria, viruses, toxins, ...
(Date:4/27/2016)... 27, 2016 ReportsnReports.com adds ... specific focus on US, EU, China ... to the healthcare business intelligence collection of its ... Complete report on the Flow Cytometry market spread ... with 282 tables and figures is now available ...
Breaking Biology Technology: