Navigation Links
CNIO researchers develop new databases for understanding the human genome
Date:12/17/2012

Scientists from the Structural Computational Biology Group at the Spanish National Cancer Research Centre (CNIO), led by Alfonso Valencia, together with French and American researchers, have published recently two articles in the journal Nucleic Acid Research (NAR) that introduce two new databases for studying the human genome.

Living eukaryote beings are capable of generating several proteins from the information contained in a single gene. This special characteristic exists partly thanks to the alternative splicing process that selectively joins some exons (the regions of genes that produce proteins) and not others, in order to produce the proteins needed in each moment.

The articles published by Valencia study the transfer of this information, which is contained in the intermediary molecules between the genes and the proteinsthe RNAs , and which will be used to understand the genome, the way it functions and the role of some of its variants in the origin of human illnesses like cancer.

An illustrative example of the relationship between RNAs and illness is the chronic lymphocytic leukemia. Researchers from the Chronic Lymphocytic Leukemia Spanish Consortium (CLL-ICGC), of which Valencia's team forms part, have observed an accumulation of mutations in the genes responsible for the splicing process. These observations suggest that alterations in these mechanisms might be the cause of the disease.

COMPILING FUNCTIONAL DATA

One of the articles published in NAR makes the APPRIS database available to the public and contains an integrated computational system that identifies those alternative splicing protein variants that are most relevant for cells.

This new database has brought together functional variants of 85% of the human genome, which "turns it into a powerful tool for analysing specific mutations in protein variants related to illness", says Michael Tess, the lead author of the article.

The APPRIS system is part of the ENCODE international project, in which more than 400 scientists from 32 laboratories in the UK, the US, Singapore, Japan, Switzerland and Spain have taken part.

A CATALOGUE OF MORE THAN 16.000 CHIMERAS

The process of splicing becomes more complex with chimeric RNAs, which are produced by the joining of exons from different genes. The second article published in NAR explains the ChiTaRS database, in which more than 16.000 chimeric RNAs from humans, mice and the fruit fly Drosophila melanogaster are brought together.

Furthermore, ChiTaRS relates some of these chimeric RNAs to chromosome alterations that are present in different types of cancer.

The entries in ChiTaRS are incorporated into the universal UniProt Knowledgebase system (UniProtKB), that contains a broad catalogue of information on proteins from laboratories around the world.

"The RNAs and chimeric proteins have become a powerful tool for researchers over the past few years, as they can be used as new cancer markers, as well as possible targets for the generation of new drugs," says Milana Frenkel-Morgenstern, the first author of the study. This new catalogue will also help further understanding of the evolution of chimeric RNAs in eukaryotes and their functions in organisms.


'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) ... of €500.0 million principal amount of its 1.414% senior unsecured ... 2.425% senior unsecured notes due 2026. The ... 2016, subject to the satisfaction of customary closing conditions.  The ... The Company intends to use the net ...
(Date:12/5/2016)... Dec. 5, 2016  The Office of Justice ... "Can CT Scans Enhance or Replace Medico Legal ... of supporting or replacing forensic autopsies with postmortem ... In response to recommendations made by ... using CT scans as a potential component of ...
(Date:11/30/2016)... , Nov. 30, 2016 Not many of us realize that we spend ... recovery so we need to do it well. Inadequate sleep levels have been found ... pressure, stroke, diabetes, and even cancer. Maybe now is the best time ... could help them to manage their sleep quality? Continue ... ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... Souderton, PA (PRWEB) , ... ... ... Technologies, part of the Almac Group, the world’s largest privately-held contract pharmaceutical ... partnership with inVentiv Health, a leading biopharma outsourcing company combining a leading ...
(Date:12/6/2016)... Colorado (PRWEB) , ... December 06, 2016 , ... ... dynamic aqueous plasma technology platforms, announced today that the company has engaged in ... Research and Development Agreement (MRDA) with the CSU Office of the Vice President ...
(Date:12/6/2016)... , Dec. 6, 2016 Zimmer Biomet Holdings, ... announced the pricing terms of its previously-announced cash ... aggregate purchase price (excluding accrued and unpaid interest ... and excluding fees and expenses related to the ... securities identified in the table below (collectively, the ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... management solutions headquartered in Aurora, Ohio, announced the opening of their new office ... the newly constructed facility is home to 200 employees focused on providing sales, ...
Breaking Biology Technology: