Navigation Links
CNIO researchers delve into the behavior of cohesins
Date:10/19/2013

Cohesins are protein complexes that join the two copies of each chromosomecalled sister chromatidsto ensure that they are shared fairly between the daughter cells during cell division. In this way, each daughter cell receives exactly the same genetic information from the parent cell.

Pds5 is a protein associated with cohesins; it binds cohesins along different chromosome regions. In vertebrates there are two variants of Pds5, Pds5A and Pds5B, not very well characterised to date. Scientists from the Spanish National Cancer Research Centre (CNIO), led by Ana Losada, from the Chromosome Dynamics Group, have discoveredby using genetically-modified mice (knock-out mice for Pds5A and Pds5B) that the two Pds5 variants are not equivalent, as both are necessary for cell proliferation and for embryo development to take place correctly.

The results, published today in the online version of The EMBO Journal, contribute to improving our understanding of how Pds5 proteins modulate the behaviour of cohesins, either by stabilising or destabilising the binding of cohesins to the chromosomes.

CLINICAL IMPLICATIONS OF THE STUDY

Illnesses such as Cornella de Lange Syndrome, which affects 1/30,000 newborns and which is characterised by serious physical abnormalities and cognitive impairments, have their origin in the abnormal function of cohesins. Cohesin mutations have recently been identified in some types of tumours, such as bladder cancer or acute myeloid leukaemia (AML). "If we understand the function and regulation of the cohesins, we can improve the diagnosis and treatment for affected patients", says Losada.

"In this context, we have seen that both forms of Pds5 stabilise the binding of cohesins to the arms and distal regions of chromosomes, whilst only Pds5B does so in the centromeres the chromosomal regions that are most critical for chromosome separation during cell division", explains Losada.

But Pds5 proteins not only stabilise cohesins, they can also have the opposite effect when they bind to the Wapl protein. "In this case, Pds5 contributes to destabilising the binding of cohesins to chromosomes, which can sometimes be important for activating essential genes at the right moment, as well as for allowing an efficient separation of the sister chromatids during cell division".


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Related biology news :

1. Rensselaer researchers propose new theory to explain seeds of life in asteroids
2. UT Dallas researchers find early success in new treatment for stroke recovery
3. University of Utah researchers receive NIH Directors New Innovator Award
4. UC Davis researchers discover a biological link between diabetes and heart disease
5. Researchers use smart phone photography to diagnose eye disease
6. University of Maryland researchers studying vaccine to prevent potential bird flu pandemic
7. Clemson researchers: Different forage affects beef cattle weight, taste
8. New HIV-1 replication pathway discovered by NYU College of Dentistry researchers
9. Rensselaer researchers create accurate computer model of RNA tetraloop
10. Researchers hit virtual heads to make safer games
11. UAlberta medical researchers discover how immune system kills healthy cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO researchers delve into the behavior of cohesins
(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, based ... entered into license agreements with Housey Pharma’s HMI subsidiary to gain access to ... have annual Research and Development spending in excess of US $10 billion. , ...
(Date:8/3/2020)... , ... August 03, 2020 , ... ... announced a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 ... to strengthen their laboratory supply chain for more than 10 years. Early in ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. ... the global economic downturn will only increase price pressures overall for the industry. The ... value from every product launch is critical. However, history shows that only a third ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... Va. (PRWEB) , ... September 01, 2020 , ... ... for life sciences, biotechnology, and diagnostics companies, has announced the placement of ... Averill will be responsible for leading all financial operations and implementing key business ...
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD ... Facioscapulohumeral Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration ... is a consortium of academic research centers in the United States and Europe ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology: